Gwen Tindula

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Syed Hasan Arshad, Gwen Tindula, Inger Kull, Anne P. Starling et autres

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Multi-tissue DNA methylation analysis to identify an appropriate surrogate tissue for a unique neurological tissue specific to spina bifida

Gwen Tindula, Sudipta Kumer Mukherjee, D. M. Arman, Joynul Islam et autres

BACKGROUND: Animal models suggest a role of epigenetic mechanisms, including DNA methylation, in neural tube closure; however, studies characterizing DNA methylation profiles in nervous system tissue from humans with spina bifida are limited. In this study, we assessed DNA methylation profiles in …

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Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese et autres

BACKGROUND: DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it is unclear whether DNAm alterations during certain developmental periods are more …

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Parental arsenic exposure and tissue-specific DNA methylation in Bangladeshi infants with spina bifida

Gwen Tindula, Sudipta Kumer Mukherjee, DM Arman, Joynul Islam et autres

An emerging hypothesis linking arsenic toxicity involves altered epigenetic mechanisms, such as DNA methylation. In this study, we examined the relationship between parents’ arsenic exposure and DNA methylation in tissues obtained from 28 infants with spina bifida from Bangladesh. We analyzed arsenic …

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Maternal arsenic exposure modifies associations between arsenic, folate and arsenic metabolism gene variants, and spina bifida risk: A case‒control study in Bangladesh

Chih‐Fu Wei, Gwen Tindula, Sudipta Kumer Mukherjee, Xingyan Wang et autres

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Arsenic modifies the effect of folic acid in spina bifida prevention, a large hospital-based case-control study in Bangladesh

Chih‐Fu Wei, Sudipta Kumer Mukherjee, DM Arman, Md Joynul Islam et autres

BACKGROUND: Spina bifida, a developmental malformation of the spinal cord, is associated with high rates of mortality and disability. Although folic acid-based preventive strategies have been successful in reducing rates of spina bifida, some areas continue to be at higher risk because …

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Genome‐wide analysis of spina bifida risk variants in a case–control study from Bangladesh

Gwen Tindula, Biju Issac, Sudipta Kumer Mukherjee, DM Arman et autres

BACKGROUND: Human studies of genetic risk factors for neural tube defects, severe birth defects associated with long-term health consequences in surviving children, have predominantly been restricted to a subset of candidate genes in specific biological pathways including folate metabolism. METHODS: In this …

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Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese et autres

Abstract DNA methylation (DNAm) is a developmentally dynamic epigenetic process, yet we still know little about how epigenetic effects on health outcomes vary over time; whether DNAm alterations during certain periods of development are more informative than others; and whether epigenetic timing …

nl, fi, es, us, gb, se, lt, pt, au, de, no, Afrique du Sud (code pays fourni par la source)

Arsenic modifies the effect of folic acid in spina bifida prevention, a large hospital-based case-control study in Bangladesh

Chih‐Fu Wei, Sudipta Kumer Mukherjee, DM Arman, Md Joynul Islam et autres

Background: Spina bifida, a developmental malformation of the spinal cord, is associated with high rates of mortality and disability. Although folic acid-based preventive strategies have been successful in reducing rates of spina bifida, some areas continue to be at higher risk because …

us, bd (code pays fourni par la source)

Maternal arsenic exposure, folic acid use during early pregnancy and spina bifida risk: A case‒control study in Bangladesh

Chih Fu Wei, Sudipta Kumer Mukherjee, DM Arman, Joynul Islam et autres

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Interactions between maternal arsenic exposure and folate pathway genes on the risk of spina bifida: A case‒control study in Bangladesh

Chih Fu Wei, Sudipta Kumer Mukherjee, DM Arman, Joynul Islam et autres

BACKGROUND AND AIM: The pathogenesis of spina bifida involves complex gene‒environment interactions, and folate pathway genes are the main targets of interest. High prenatal arsenic exposure increases the risk of spina bifida in experimental animals, possibly by its disruption of folate metabolism. …

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Multi-tissue DNA methylation analysis to identify an appropriate surrogate tissue for a unique tissue specific to spina bifida

Gwen Tindula, Sudipta Kumer Mukherjee, DM Arman, Joynul Islam et autres

us, bd (code pays fourni par la source)