Corey R. Seehus

Increased Na V 1.2 expression and its interaction with CaM contribute to the hyperexcitability induced by prolonged inhibition of CaMKII

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Abstract Objective Dysfunction of calcium/calmodulin (CaM)–dependent kinase II (CaMKII) has been involved in hyperexcitability‐related disorders including epilepsy. However, the relationship between CaMKII and neuronal excitability remains unclear. Methods Neuronal excitability was detected in vivo and in vitro by electroencephalography (EEG), patch clamp …

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TRPM7 contributes to pyroptosis and its involvement in status epilepticus

Xin Tong, Tong Yu, Jiahe Zheng, Ruixue Shi et autres

BACKGROUND: Pyroptosis, a novel form of programmed cell death, has been implicated in neurodegeneration diseases. However, its role in status epilepticus (SE)-a condition characterized by prolonged or repeated seizures-remains inadequately understood. METHODS: SE were induced by intraperitoneal injection of pilocarpine (PILO). Neuronal …

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A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

Simmie L. Foster, Abigail J. Dutton, Adina Yerzhan, Lindsay B. March et autres

Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer's disease (AD) and depression. Exposure to elevated temperature (hyperthermia) is proposed as a non-pharmacological, anti-inflammatory treatment for these disorders; however, the underlying mechanisms are not fully understood. …

us, ca, se (code pays fourni par la source)

Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …

us, cn, pl (code pays fourni par la source)

Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …

us, cn, pl (code pays fourni par la source)

Nociceptor neurons affect cancer immunosurveillance

Mohammad Balood, Maryam Ahmadi, Tuany Eichwald, Ali Ahmadi et autres

Abstract Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems 1–5 . Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immunosurveillance remains unclear. Here we show that melanoma cells interact with …

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Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …

us, cn, pl (code pays fourni par la source)

Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …

us, cn, pl (code pays fourni par la source)

Prolonged inhibition of CaMKII results in hyperexcitability by increasing NaV1.2 expression and its interaction with CaM

Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres

Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …

us, cn, pl (code pays fourni par la source)

Nociceptor neurons promote IgE class switch in B cells

Shreya Mathur, Jo-Chiao Wang, Corey R. Seehus, Florence Poirier et autres

Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with immune cells in the periphery to modulate innate immune responses. Whether they also participate in adaptive and humoral immunity is, however, not known. In this study, we probed if nociceptors have …

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Nociceptor neurons impair cancer immunosurveillance

Sébastien Talbot, Mohammad Balood, Maryam Ahmadi, Tuany Eichwald et autres

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FcεR1-expressing nociceptors trigger allergic airway inflammation

Théo Crosson, Jo-Chiao Wang, Benjamin Doyle, Hannah Merrison et autres

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