Accès ouvert
2025
article
OpenAlex
Adetola H. Adewole, Bhuwan K. Chhetri, Ghada M. Abdelwahab, Riya Bhanushali et autres
High Resolution Image Download MS PowerPoint Slide Automated high-throughput screening of a prefractionated extract library of marine macroorganisms identified 239 hits (hit rate 2.5%), including a marine algal extract that blocked the Na v 1.7 channel in a fluorescent-based flux assay. Bioactivity-guided …
us, bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hyung Suk Oh, Shu-Fan Chou, Priya Raja, Jaehoon Shim et autres
Herpes simplex virus 1 (HSV-1) undergoes primary acute lytic replication in mucosal epithelial cells and then spreads to establish latent infection in peripheral neurons including sensory and autonomic neurons. Latent HSV-1 reactivates to cause recurrent cold sores but can also cause more …
us, ch
(code pays fourni par la source)
Accès ouvert
2025
erratum
OpenAlex
Jaehoon Shim, Brian S. Tanaka, Daniel G. Taub, Malgorzata A. Mis et autres
Inherited erythromelalgia, small fibre neuropathy and paroxysmal extreme pain disorder are caused by gain-of-function mutations in the voltage-gated sodium channel Nav1.7. It remains unknown how different mutations in the same channel enhancing electrogenesis in sensory neurons results in such distinct disease presentations. …
us
(code pays fourni par la source)
2025
article
OpenAlex
Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres
Abstract Objective Dysfunction of calcium/calmodulin (CaM)–dependent kinase II (CaMKII) has been involved in hyperexcitability‐related disorders including epilepsy. However, the relationship between CaMKII and neuronal excitability remains unclear. Methods Neuronal excitability was detected in vivo and in vitro by electroencephalography (EEG), patch clamp …
cn, us, pl, jp
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Accès ouvert
2024
article
OpenAlex
Yumi Kotoda, Sohei Hishiyama, Jaehoon Shim, Hiroki Kobayashi et autres
Purpose: Corneal pain is one of the most common eye symptoms caused by various types of epithelial injuries, including traumatic abrasion, chemical injury, ulcers, ultraviolet exposure, and infection. However, current therapeutic options for corneal pain are limited. In this study, we synthesized …
jp, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Tao Deng, Vukasin M. Jovanovic, Carlos A. Tristan, Claire Weber et autres
Development of new non-addictive analgesics requires advanced strategies to differentiate human pluripotent stem cells (hPSCs) into relevant cell types. Following principles of developmental biology and translational applicability, here we developed an efficient stepwise differentiation method for peptidergic and non-peptidergic nociceptors. By modulating …
us
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Accès ouvert
2023
article
OpenAlex
Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim et autres
Gain-of-function mutations in Scn9a, which encodes the peripheral sensory neuron-enriched voltage-gated sodium channel Nav1.7, cause paroxysmal extreme pain disorder (PEPD), inherited erythromelalgia (IEM), and small fiber neuropathy (SFN). Conversely, loss-of-function mutations in the gene are linked to congenital insensitivity to pain (CIP). …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
M. Carmen Ruiz‐Cantero, Elsa Cortés‐Montero, Aakanksha Jain, Ángeles Montilla‐García et autres
BACKGROUND AND PURPOSE: -sensing chaperone known to modulate opoid analgesia. This receptor binds both to TRPV1 and the μ opioid receptor, although the functional repercussions of these physical interactions in peripheral sensitization are unknown. EXPERIMENTAL APPROACH: We tested the effects of sigma-1 …
es, us
(code pays fourni par la source)
Accès ouvert
2022
dataset
OpenAlex
Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres
Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …
us, cn, pl
(code pays fourni par la source)
Accès ouvert
2022
dataset
OpenAlex
Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres
Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …
us, cn, pl
(code pays fourni par la source)
Accès ouvert
2022
dataset
OpenAlex
Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres
Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …
us, cn, pl
(code pays fourni par la source)
Accès ouvert
2022
dataset
OpenAlex
Hongyue Liang, Ling Qin, Rui Feng, Jaehoon Shim et autres
Dysfunction of calcium/calmodulin (CaM)-dependent kinase II (CaMKII) has been involved in hyperexcitability-related disorders including epilepsy. However, the exact mechanism by which CaMKII inhibits neuronal excitability remains to be elucidated. In the present study, we found that seizure-like events recorded by EEG in …
us, cn, pl
(code pays fourni par la source)