Sho Maejima

Chronic theobromine administration attenuates short-term memory decline via neurotrophic, anti-inflammatory and antioxidant mechanisms in senescence-accelerated mouse prone 8 (SAMP8)

Eri Sumiyoshi, Kentaro Matsuzaki, Masanori Katakura, Shadman Nazib et autres

jp, bd (code pays fourni par la source)

Potential of functional flavonoids in targeting vasospasm through modulation of oxidative stress and SPC-induced signaling pathways

Ying Zhang, Sho Maejima, Kentaro Matsuzaki, Hiroko Kishi

Vasospasm is a sustained abnormal contraction of vascular smooth muscle (VSM), which is commonly observed in the coronary and cerebral arteries. This abnormal VSM contraction leads to reduced blood flow to tissues or organs, ultimately causing severe diseases such as myocardial infarction …

jp (code pays fourni par la source)

Oxytocin facilitates human touch-induced play behavior in rats

Himeka Hayashi, Sayaka Tateishi, Ayumu Inutsuka, Sho Maejima et autres

Pleasant touch sensations play a fundamental role in social bonding, yet the neural mechanisms underlying affinity-like behaviors remain poorly understood. Here, we demonstrate that juvenile-adolescent rats, which naturally engage in social play with peers characterized by rough-and-tumble interactions and 50 kHz ultrasonic …

jp, ie, de (code pays fourni par la source)

LP-08: Sodium Arsenite Attenuates the Cytoskeletal Gene Expression and Alters Morphology of Primarily Cultured Mouse Cortical Astrocytes

Nang Thinn Thinn Htike, Fumihiko Maekawa, Shin Kobayashi, Sho Maejima et autres

my, jp (code pays fourni par la source)

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition

Yuki Sato, Mugiho Shigematsu, Maria Shibata-Kanno, Sho Maejima et autres

Endothelial-to-hematopoietic transition (EHT) is crucial for hematopoietic stem cell (HSC) generation. During EHT, the morphology of hemogenic endothelial cells (HECs) changes from flat and adherent to spherical hematopoietic cells, which detach from the dorsal aorta. HECs attain a rounded shape in a …

jp (code pays fourni par la source)

Nanobody-based RFP-dependent Cre recombinase for selective anterograde tracing in RFP-expressing transgenic animals

Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko et autres

Transgenic animals expressing fluorescent proteins are widely used to label specific cells and proteins. By using a split Cre recombinase fused with mCherry-binding nanobodies or designed ankyrin repeat proteins, we created Cre recombinase dependent on red fluorescent protein (RFP) (Cre-DOR). Functional binding …

jp (code pays fourni par la source)

Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition

Yuki Sato, Mugiho Shigematsu, Maria Shibata-Kanno, Sho Maejima et autres

ABSTRACT Endothelial-to-hematopoietic transition (EHT) is crucial for hematopoietic stem cell (HSC) generation. During EHT, the morphology of hemogenic endothelial cells (HECs) changes from flat and adherent to spherical HSCs, which detach from the dorsal aorta. HECs attain a rounded shape in a …

jp (code pays fourni par la source)

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Kensho Kanehisa, Keisuke Koga, Sho Maejima, Yuto Shiraishi et autres

Abstract An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical for pruriceptive transmission. Here, we show that glutamatergic excitatory inputs onto GRPR+ neurons are facilitated in mouse models of chronic itch. In these …

jp, us (code pays fourni par la source)

Vasopressin-oxytocin–type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians

Aoshi Kobayashi, Mayuko Hamada, Masaaki Yoshida, Yasuhisa Kobayashi et autres

Vasopressin/oxytocin (VP/OT)-related peptides are essential for mammalian antidiuresis, sociosexual behavior, and reproduction. However, the evolutionary origin of this peptide system is still uncertain. Here, we identify orthologous genes to those for VP/OT in Platyhelminthes, intertidal planarians that have a simple bilaterian body …

jp, nz, gb (code pays fourni par la source)

Nanobody-Based RFP-Dependent Cre Recombinase for Selective Anterograde Tracing in RFP-Expressing Transgenic Animals

Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko et autres

Abstract Transgenic animals expressing fluorescent proteins are widely used to label specific cells and proteins. GFP-dependent gene regulation utilizes these lines to manipulate gene expression; however, its application has been limited to fluorescent proteins derived from Aequorea jellyfish. By using a split …

jp (code pays fourni par la source)

Immunoelectron Microscopic Characterization of Vasopressin-Producing Neurons in the Hypothalamo-Pituitary Axis of Non-Human Primates by Use of Formaldehyde-Fixed Tissues Stored at −25 °C for Several Years

Akito Otubo, Sho Maejima, Takumi Oti, Keita Satoh et autres

Translational research often requires the testing of experimental therapies in primates, but research in non-human primates is now stringently controlled by law around the world. Tissues fixed in formaldehyde without glutaraldehyde have been thought to be inappropriate for use in electron microscopic …

jp, gb (code pays fourni par la source)

Immuno-EM characterization of vasopressin neurons in macaques by use of formaldehyde-fixed tissues stored for several years

Akito Otubo, Sho Maejima, Takumi Oti, Keita Satoh et autres

Abstract Translational research often requires the testing of experimental therapies in primates, but research in non-human primates is now stringently controlled by law around the world. Tissues fixed in formaldehyde without glutaraldehyde have been thought to be inappropriate for use in electron …

jp, gb (code pays fourni par la source)