Mark A. Greiner

Ocular adnexal plasmacytoma presenting as a lesion of the plica semilunaris and caruncle in a 21-year-old male

Hend M. Al‐Kaylani, Guadalupe Torres, Carol Holman, Elaine M. Binkley et autres

Purpose Solitary extramedullary plasmacytoma (SEMP) makes up 2-5% of plasma cell dyscrasias and is defined as a plasma cell neoplasm in the absence of systemic multiple myeloma or other dyscrasia. A rare subset of SEMP is plasmacytoma located in the ocular adnexa, …

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Ferritinophagy Contributes to Iron Accumulation and Ferroptosis in Fuchs Endothelial Corneal Dystrophy

Zachary Shepard, Jessica M. Skeie, Hanna Shevalye, Timothy Eggleston et autres

ABSTRACT Purpose Fuchs endothelial corneal dystrophy (FECD) is a progressive disease, causing premature death of corneal endothelial cells (CECs). Iron-dependent lipid peroxidation and ferroptosis mediate cell death in FECD. We aimed to determine whether FECD progression is mediated by derangements in ferritinophagy …

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Factors Associated with Successful Descemet Membrane Endothelial Keratoplasty in the Diabetes Endothelial Keratoplasty Study

Marianne O. Price, Loretta Szczotka‐Flynn, Zachariah W. Reed, Robin L. Gal et autres

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Factors Associated with Endothelial Cell Density at One Year in the Diabetes Endothelial Keratoplasty Study

Sanjay V. Patel, Beth Ann Benetz, Marianne O. Price, Zachariah W. Reed et autres

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Validation of Automated Software for Guttae Quantification in Fuchs Endothelial Corneal Dystrophy

Simran Sarin, Jérôme Abou Assi, Jessica M. Skeie, Pierre Deman et autres

Purpose: Corneal guttae are the hallmark pathologic phenotype of Fuchs endothelial corneal dystrophy (FECD). Tools performing quantitative analysis of guttae and their changes over time are needed as medical therapies advance. We developed and validated a novel automated software platform that reports …

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Donor Diabetes and 1-Year Descemet Membrane Endothelial Keratoplasty Success Rate

Francis W. Price, Loretta Szczotka‐Flynn, Marianne O. Price, Colleen Bauza et autres

Importance: If the success of Descemet membrane endothelial keratoplasty (DMEK) is not affected by whether the donor has diabetes, then the donor pool should expand. Objective: To determine whether the 1-year DMEK success rate is affected by the presence of diabetes in …

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Corneal transplantation wound dehiscence after penetrating keratoplasty and deep anterior lamellar keratoplasty

Simran Sarin, Mark A. Greiner, Gregory A. Schmidt, Kanwal S. Matharu et autres

PURPOSE: To study clinical characteristics and outcomes of penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) wound dehiscence. METHODS: This retrospective case series assessed PK and DALK recipients with wound dehiscence at a single institution. We evaluated relationships between dehiscence etiologies, …

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Delphi-Based Global Consensus on Fuchs Endothelial Corneal Dystrophy. An Endothelial Keratoplasty Learners Group Initiative

Sanjay V. Patel, Nidhi Gupta, Maninder Bhogal, Ula V. Jurkunas et autres

us, in, gb, jp, ca, it, ch, de, es, dk, sg, il, au, co, fr, br, sa (code pays fourni par la source)

Functional Assessment of Fuchs Endothelial Corneal Dystrophy in the National Advanced Driving Simulator: Initial Study of Nighttime Glare and Scheimpflug Imaging

Simran Sarin, Matthew Kigin, Evan Balk, Ryan J. Diel et autres

PURPOSE: The aim of this study was to quantify nighttime driving differences in patients with Fuchs endothelial corneal dystrophy (FECD) using the FDA-validated National Advanced Driving Simulator MiniSim. METHODS: We conducted a pilot study to calculate sample size, followed by a prospective …

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Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy

Emma M. Hartness, Hanna Shevalye, Jessica M. Skeie, Timothy Eggleston et autres

Purpose: Evidence suggests that corneal endothelial cell (CEC) death in Fuchs endothelial corneal dystrophy (FECD) is due to ferroptosis, an iron-mediated cell death. Iron-sulfur cluster (ISC)-containing aconitases and the iron responsive element binding proteins IREBP1 and IREBP2 are known mediators of iron …

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Diabetes Endothelial Keratoplasty Study: Methods and Impact on the Use of Corneas From Donors With Diabetes for Descemet Membrane Endothelial Keratoplasty

Marianne O. Price, Loretta Szczotka‐Flynn, Colleen Bauza, Zachariah W. Reed et autres

PURPOSE: Describe aims, methods, characteristics of donors, donor corneas and recipients, and potential impact of the Diabetes Endothelial Keratoplasty Study (DEKS). METHODS: The DEKS is a randomized, clinical trial to assess graft success and endothelial cell density (ECD) 1 year after Descemet …

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Exposure Keratopathy

Caroline Yu, Mark A. Greiner, Mark Fisher, Erin M. Shriver

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