Alba Bergas

Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia

Júlia Laporte-Amargós, Marta Ulldemolins, María Patricia Hernández-Mitre, Raül Rigo‐Bonnin et autres

ABSTRACT Hematological patients with febrile neutropenia receiving piperacillin-tazobactam may experience pharmacokinetic alterations that compromise drug exposure. We aimed to characterize the population pharmacokinetics of piperacillin in plasma and provide optimized dosing recommendations for this patient population. A population pharmacokinetic analysis was conducted …

es, au, Ouganda, fr (code pays fourni par la source)

Effectiveness of the BioFire FilmArray for the rapid detection of bloodstream infection in haematological patients with febrile neutropenia (the ONFIRE study): study protocol of a prospective, multicentre observational study at three reference university hospitals in Spain

Alba Bergas, Guillem López de Egea, Adaia Albasanz‐Puig, Marina Machado et autres

INTRODUCTION: Bloodstream infection (BSI) due to multidrug-resistant Gram-negative bacilli is a serious global health problem that has a profound impact on severely immunosuppressed neutropenic haematological patients. Prompt institution of appropriate antimicrobial therapy is crucial for improving outcomes in these patients, and in …

es (code pays fourni par la source)

Ceftazidime/avibactam for the treatment of bloodstream infection due to carbapenemase-producing Enterobacterales in onco-haematologic neutropenic patients (the TARZAN study)

Enric Sastre, Fotinie Ntziora, Matteo Chiurlo, Pilar Martín‐Dávila et autres

OBJECTIVES: To assess the clinical features, antibiotic therapy and outcomes of carbapenemase-producing Enterobacterales bloodstream infection (CPE-BSI) in neutropenic patients with haematological malignancies treated with ceftazidime/avibactam. METHODS: We conducted a multicentre, international, retrospective, descriptive study of CPE-BSI episodes in neutropenic onco-haematological patients treated …

es, gr, it (code pays fourni par la source)

Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Małgorzata Mikulska, del Pozo J.L., Natàlia Pallarés, Jordi Carratalà et autres

We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls …

us (code pays fourni par la source)

An Ocean between the Waves: Trends in Antimicrobial Consumption in Hospitalized Patients with COVID-19

Xavier Durà-Miralles, Gabriela Abelenda-Alonso, Alba Bergas, Júlia Laporte-Amargós et autres

We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of the COVID-19 pandemic, as well as its trends over the period and associated risk factors. We performed a cross-sectional retrospective analysis nested in a prospectively collected cohort of hospitalized …

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The Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-Hematological Patients

Valeria Castelli, Enric Sastre, Pedro Puerta‐Alcalde, Leyre Huete-Álava et autres

OBJECTIVES: to assess the current epidemiology, antibiotic therapy and outcomes of onco- hematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for early and overall mortality. METHODS: episodes of bacteremic …

it, es (code pays fourni par la source)

Increasing Gram-Negative Catheter-Related Bloodstream Infection in Cancer Patients

Júlia Laporte-Amargós, Enric Sastre, Alba Bergas, Helena Pomares et autres

Background: We aimed to assess the incidence, etiology and outcomes of catheter-related bloodstream infection (CRBSI) in onco-hematological patients, to assess the differences between patients with hematological malignancies (HMs) and solid tumors (STs) and to identify the risk factors for Gram-negative (GN) CRBSI. …

es (code pays fourni par la source)

Native and prosthetic transcatheter aortic valve infective endocarditis due to Lactobacillus rhamnosus

Alba Bergas, Samuel Rivera, Miriam Torrecillas, Guillermo Cuervo

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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Alba Bergas, Adaia Albasanz‐Puig, Ana Fernández‐Cruz, Marina Machado et autres

Ceftolozane-tazobactam (C/T) has been shown to be a safe and effective alternative for the treatment of difficult to treat infections due to Pseudomonas aeruginosa (PA) in the general nonimmunocompromised population. However, the experience of this agent in immunosuppressed neutropenic patients is very …

es, us, it, sk (code pays fourni par la source)

Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Adaia Albasanz‐Puig, Xavier Durà-Miralles, Júlia Laporte-Amargós, Alberto Mussetti et autres

To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect …

es, br, it, tr, ar, sk, ch, de, lb, cl, gb (code pays fourni par la source)

Immunomodulatory therapy, risk factors and outcomes of hospital-acquired bloodstream infection in patients with severe COVID-19 pneumonia: a Spanish case–control matched multicentre study (BACTCOVID)

Gabriela Abelenda-Alonso, Alexander Rombauts, Carlota Gudiol, Isabel Oriol et autres

OBJECTIVES: The effect of the use of immunomodulatory drugs on the risk of developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify risk factors for, and outcomes of, BSI among hospitalized patients with …

es (code pays fourni par la source)

Immunomodulatory therapy, risk factors and outcomes of hospital-acquired bloodstream infection in patients with severe COVID-19 pneumonia: a Spanish case-control matched multicenter study (BACTCOVID)

Gabriela Abelenda Alonso, Alexander Rombauts, Carlota Gudiol González, Isabel Oriol et autres

Objectives The effect of the use of immunomodulatory drugs on the risk of developing hospital-acquired bloodstream infection (BSI) in patients with COVID-19 has not been specifically assessed. We aim to identify risk factors for, and outcomes of, BSI among hospitalized patients with …