Xavier Durà-Miralles

Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study

Pilar Martín‐Dávila, J. Aguilar-Company, Belén Gutiérrez‐Gutiérrez, Nathalie De Castro et autres

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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Małgorzata Mikulska, del Pozo J.L., Natàlia Pallarés, Jordi Carratalà et autres

We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls …

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An Ocean between the Waves: Trends in Antimicrobial Consumption in Hospitalized Patients with COVID-19

Xavier Durà-Miralles, Gabriela Abelenda-Alonso, Alba Bergas, Júlia Laporte-Amargós et autres

We assessed the antibiotic use in SARS-CoV-2-infected patients during four different waves of the COVID-19 pandemic, as well as its trends over the period and associated risk factors. We performed a cross-sectional retrospective analysis nested in a prospectively collected cohort of hospitalized …

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Characteristics of long-COVID among older adults: a cross-sectional study

Vered Daitch, Dana Yelin, Muhammad Awwad, Giovanni Guaraldi et autres

OBJECTIVES: To describe long-COVID symptoms among older adults and to assess the risk factors for two common long-COVID symptoms: fatigue and dyspnea. METHODS: This is a multicenter, prospective cohort study conducted in Israel, Switzerland, Spain, and Italy. Individuals were included at least …

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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Alba Bergas, Adaia Albasanz‐Puig, Ana Fernández‐Cruz, Marina Machado et autres

Ceftolozane-tazobactam (C/T) has been shown to be a safe and effective alternative for the treatment of difficult to treat infections due to Pseudomonas aeruginosa (PA) in the general nonimmunocompromised population. However, the experience of this agent in immunosuppressed neutropenic patients is very …

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Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Adaia Albasanz‐Puig, Xavier Durà-Miralles, Júlia Laporte-Amargós, Alberto Mussetti et autres

To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect …

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Patterns of Long COVID Symptoms: A Multi-Center Cross Sectional Study

Dana Yelin, Ili Margalit, Mayssam Nehme, Jaume Bordas-Martínez et autres

BACKGROUND: Long COVID has become a burden on healthcare systems worldwide. Research into the etiology and risk factors has been impeded by observing all diverse manifestations as part of a single entity. We aimed to determine patterns of symptoms in convalescing COVID-19 …

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Co-infections and superinfections complicating COVID-19 in cancer patients: A multicentre, international study

Carlota Gudiol, Xavier Durà-Miralles, Pilar Hernández-Jiménez, M. Martínez‐Cutillas et autres

BACKGROUND: We aimed to describe the epidemiology, risk factors, and clinical outcomes of co-infections and superinfections in onco-hematological patients with COVID-19. METHODS: International, multicentre cohort study of cancer patients with COVID-19. All patients were included in the analysis of co-infections at diagnosis, …

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Impact of the Inclusion of an Aminoglycoside to the Initial Empirical Antibiotic Therapy for Gram-Negative Bloodstream Infections in Hematological Neutropenic Patients: a Propensity-Matched Cohort Study (AMINOLACTAM Study)

Adaia Albasanz‐Puig, Carlota Gudiol, Pedro Puerta‐Alcalde, Çağlayan Merve Ayaz et autres

To test the hypothesis that the addition of an aminoglycoside to a β-lactam antibiotic could provide better outcomes than β-lactam monotherapy for the initial empirical treatment of hematological neutropenic patients with subsequently documented Gram-negative bacillus (GNB) bloodstream infection (BSI), a multinational, retrospective, …

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