Dan Alexandru Cozac

Artificial Intelligence for Precision Antiarrhythmic Drug Therapy in Atrial Fibrillation: From Recurrence Prediction to Comparative Treatment Selection

Alina Scridon, Vasile-Bogdan Halațiu, Dan Alexandru Cozac

Rhythm control therapy has an important role in atrial fibrillation (AF) management, and antiarrhythmic drugs (AADs) remain essential for pharmacological cardioversion, maintenance of sinus rhythm, reduction in AF burden, and treatment before or after catheter ablation. However, their efficacy varies substantially among …

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Correction: Balan et al. The Diagnostic and Predictive Potential of miR-328 in Atrial Fibrillation: Insights from a Spontaneously Hypertensive Rat Model. Int. J. Mol. Sci. 2025, 26, 3049

Alkora Ioana Balan, Vasile-Bogdan Halațiu, Emilian Comșulea, Cosmin Constantin Mutu et autres

There was a citation error in the original publication [...].

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Pharmacologic therapies for hypertrophic cardiomyopathy: The past, the present, and the future

Vasile-Bogdan Halațiu, Dan Alexandru Cozac, Alina Scridon

Hypertrophic cardiomyopathy (HCM) stands as the most common monogenic cardiac disease, with an estimated prevalence historically reported as 1:500, but likely closer to 1:200 based on contemporary population studies in the general population. The past decade has marked a fundamental shift in …

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Computed tomography-derived score as a predictor of major adverse cardiovascular events in patients with severe aortic stenosis

Maria Teresa Savo, Valeria Pergola, Morena De Amicis, Dan Alexandru Cozac et autres

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Multidetector Computed Tomography and Aortic Stenosis: The Emerging Potential of Bridging Morphology and Severity Grading

Gabriele Cordoni, Diana Di Paolantonio, Maria Teresa Savo, Dan Alexandru Cozac et autres

Background/Objectives: Echocardiography is the reference standard for grading aortic stenosis (AS); however, it yields discordant severity estimates in up to 40% of patients. Multidetector computed tomography (MDCT)-derived methods for calculating aortic valve area (AVA) may improve diagnostic concordance, but their diagnostic performance, …

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Sodium-glucose transporter 2 inhibitors and their antiarrhythmic role: New insights and future perspective

Diana-Ioana Prația-Aron, Dan Alexandru Cozac, Alina Scridon

Abstract Sodium-glucose transporter 2 inhibitors have been identified as pleiotropic pharmacological agents with demonstrated efficacy in a wide range of pathologies. Given the strong association between arrhythmias and significant comorbidities, exploring the potential antiarrhythmic effects of sodium-glucose transporter 2 inhibitors represents a …

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Autonomic modulation in ventricular arrhythmias: Clinical insights and therapeutic opportunities

Ovidiu Șerban Marcu, Dan Alexandru Cozac, Alina Scridon

Abstract Recent evidence establishes robust causal relationships between autonomic nervous system dysfunction and ventricular arrhythmias through multiple converging mechanisms. Direct neural recording studies demonstrate that sympathetic discharge from the left stellate ganglion immediately precedes ventricular fibrillation. At the same time, mechanistic investigations …

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Machine learning approach to predict 1-year mortality after heart transplantation: a single-centre study

Batol Allehyani, Maria Teresa Savo, Adel Khwaji, Naji Kholaif et autres

Aims: Heart transplantation is a critical life-saving procedure for patients with end-stage heart failure. However, predicting postoperative mortality remains challenging. The aim of this study is to examine the effectiveness of machine learning (ML) models for predicting 1-year mortality among heart transplant …

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miRNA-Orchestrated Fibroinflammatory Responses in Heart Failure with Preserved Ejection Fraction: Translational Opportunities for Precision Medicine

Dan Alexandru Cozac, Alina Scridon

Heart failure with a preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases. It continues to impose a significant global cardiovascular burden due to its rising prevalence, complex pathophysiology, and limited treatment options. The absence of effective disease-modifying …

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Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric Cancer

Andreea-Raluca Cozac-Szőke, Andreea Cătălina Tinca, Anca Negovan, Alexandra Vilaia et autres

Gastric cancer remains a major global health burden, with limited response rates to current immunotherapies targeting the programmed death-ligand 1 (PD-1/PD-L1) axis. Recent studies have identified sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC-15) as a novel immune checkpoint molecule that may drive immune …

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The alarmin tandem: unraveling the complex effect of S100A8/A9 – from atherosclerosis to cardiac arrhythmias

Dan Alexandru Cozac, Vasile-Bogdan Halațiu, Alina Scridon

Introduction: Inflammation plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs), particularly in heart failure (HF), cardiac arrhythmias, and atherosclerotic cardiovascular disease (ASCVD). The calcium-binding proteins S100A8 and S100A9, primarily functioning as a heterodimer (S100A8/A9), have emerged as essential mediators …

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The Impact of Basal Inflammatory Status on Post-CABG Atrial and Ventricular Ectopy and Remodeling Pathways

Dan Alexandru Cozac, Cristina Somkereki, Adina Huţanu, Tunde Renata Nicoară et autres

Background and Objectives: Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) commonly occur after coronary artery bypass grafting (CABG) surgery, with frequent ectopics linked to atrial fibrillation risk and reduced heart function. While CABG-induced inflammation causes arrhythmogenic changes, the connection between …

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