Naji Kholaif

A TLS11a-decorated ionizable lipid nanoparticle platform and a multilevel-validated CRISPR LDLR-knockout HepG2 model for hepatocyte-preferential mRNA delivery

Irfan Hussain, Naji Kholaif, Raghad Alsultan, Rahma Eltahir et autres

Abstract Ionizable lipid nanoparticles (LNPs) are widely used for delivery of CRISPR/Cas9 payloads to hepatocytes, but conventional hepatic uptake is strongly influenced by adsorption of apolipoprotein E and subsequent low-density lipoprotein receptor (LDLR)-mediated internalization. This dependence may limit specificity and reduce efficacy …

sa, tr, pk (code pays fourni par la source)

Demographics, Clinical Characteristics, and Barriers to Care in Patients with Dyslipidaemia in the Arabian Gulf Region: The Gulf ACTION Registry

Khalid F. AlHabib, Hanan Albackr, K. Al Waili, Wael Almahmeed et autres

INTRODUCTION: This study evaluates dyslipidaemia management in the Arabian Gulf region. METHODS: The multicentre, multinational longitudinal Gulf ACTION registry includes adults (≥18 years old) on lipid-lowering therapy (LLT) recruited from outpatient clinics at 14 tertiary care centres and 9 primary care clinics …

sa, om, us, kw, mn, Égypte, ae (code pays fourni par la source)

Saudi Secondary Prevention Survey Study in Patients with Prior Acute Myocardial Infarction (4S Registry): Study Design and Pilot Phase Results

Rakan K. Alhabib, Naji Kholaif, Mohammed Mahmoud, Abdulrahman Alnwiji et autres

Patients with prior acute myocardial infarction (AMI) generally show low rates of achieving secondary prevention targets. Here we evaluated adherence to guideline-recommended secondary prevention strategies after AMI in Saudi Arabia. This ambispective multicenter cohort study included consecutive patients seen for follow-up visits …

sa (code pays fourni par la source)

Lomitapide in paediatric patients with homozygous familial hypercholesterolaemia (HoFH) – Analysis of long-term (104-week) safety and efficacy from the APH-19 study

Phil Dawson, Luis Masana, Alberto Zambon, Claus Peter Schmitt et autres

gb, es, it, de, il, sa, Tunisie, ca, fr (code pays fourni par la source)

Machine learning approach to predict 1-year mortality after heart transplantation: a single-centre study

Batol Allehyani, Maria Teresa Savo, Adel Khwaji, Naji Kholaif et autres

Aims: Heart transplantation is a critical life-saving procedure for patients with end-stage heart failure. However, predicting postoperative mortality remains challenging. The aim of this study is to examine the effectiveness of machine learning (ML) models for predicting 1-year mortality among heart transplant …

sa, it, au, ro (code pays fourni par la source)

Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III

Johanna A van der Zande, Jasmin Grewal, Arie Franx, Wael Al Mahmeed et autres

BACKGROUND AND AIMS: Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome is limited. We examine the cardiovascular and pregnancy outcomes in these women and analyze aortic growth throughout pregnancy. METHODS: The ROPAC III is a global, prospective, …

nl, ca, se, be, sa, Botswana, fr, us, gb (code pays fourni par la source)

The second survey of the Saudi Acute Myocardial Infarction Registry Program: Main results and temporal changes in care (STARS-2 program)

Shukri M. AlSaif, Osama Alhadramy, Mohammed Alshehri, Khalid Al Faraidy et autres

BACKGROUND: The Saudi Acute Myocardial Infarction Registry (STARS) program aims to evaluate the clinical characteristics, management, and outcomes of a representative sample of patients with acute myocardial infarction (AMI) in Saudi Arabia. This second phase evaluates temporal changes in patient care, demographics, …

sa, pk, ca (code pays fourni par la source)

Lomitapide in paediatric patients with homozygous familial hypercholesterolaemia (HOFH) – Analysis of long-term (104-week) safety and efficacy from the APH-19 study

Luís Masana-Marín, Alberto Zambon, Claus Peter Schmitt, Christina Taylan et autres

es, it, de, il, sa, Tunisie, no, fr (code pays fourni par la source)

Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III

Johanna A van der Zande, Julie De Backer, Guillaume Jondeau, Osama Ahmad et autres

AIMS: The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient management and care. METHODS AND …

nl, be, fr, sa, us, it, se, ru, gb (code pays fourni par la source)

Valve replacement during pregnancy: literature review including new data from the Registry Of Pregnancy And Cardiac disease III

Johanna A van der Zande, С. О. Сіромаха, Ghada Youssef, Laura Galián-Gay et autres

OBJECTIVES: Heart valve replacement during pregnancy is sometimes unavoidable, and the need for anticoagulation further complicates these procedures. Our study describes cases of valve replacement in pregnancy enrolled in the Registry Of Pregnancy And Cardiac disease (ROPAC) III and gives an overview …

nl, ua, Égypte, es, fr, us, gb (code pays fourni par la source)

Infective endocarditis and oral health: a long-known threat, still a challenge

Mohamed Alsergani, Renad Hatim Zaini, Naji Kholaif, Mohammed Al Admawi et autres

Infective endocarditis (IE) remains a life-threatening condition associated with high morbidity and mortality, often influenced by the complex interplay between systemic and oral health. The increasing recognition of oral health as a risk modifier has led to greater focus on the oral …

sa, it, ro (code pays fourni par la source)

Homozygous familial hypercholesterolemia evaluation and survival single center study in Saudi Arabia: The HESSA registry

Naji Kholaif, Lin Batha, Sumayah Aljenedil, Zuhier Awan et autres

BACKGROUND AND AIMS BACKGROUND: Homozygous Familial Hypercholesterolemia (HoFH) is a rare, life-threatening genetic disorder causing extremely high low density lipoprotein cholesterol (LDL-C) levels, leading to early cardiovascular disease (CVD) and premature death. In Saudi Arabia, where consanguinity is common, HoFH prevalence is …

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