Davide Gobbo

Astrocyte Proximity Protects Synapses From Human Amyloid‐Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo et autres

Synapse loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) and is most pronounced around amyloid plaque pathology in the brain. Although mechanisms remain incompletely understood, hyperactivity downstream of soluble amyloid beta (Aβ) is strongly implicated in synapse …

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Author response for "Astrocyte proximity protects synapses from human amyloid-beta induced degeneration in a mouse in vitro model of early Alzheimer’s disease"

Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo et autres

Sex-Specific Properties of Astrocytes: From Development to Evolutionary Insights

Mariza Bortolanza, Davide Gobbo, Li‐Pao Fang, Anja Scheller et autres

Exploring sex-specific differences in astrocytes has emerged as a vital area of neurobiological research. This research sheds light on how astrocytes in females and males differ in their contribution to neuronal functionality, overall brain health, and various neurological disorders. These cells play …

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Cannabidiol reverses microglia activation and deficits of parvalbumin interneurons and their perineuronal nets in a MK-801-induced mouse model of schizophrenia

Naielly Rodrigues da Silva, Davide Gobbo, Felipe V. Gomes, Anja Scheller et autres

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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao et autres

Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in …

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Animal-based approaches to understanding neuroglia physiology in vitro and in vivo

Davide Gobbo, Frank Kirchhoff

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Cannabidiol Reverses Microglia Activation and Loss of Parvalbumin Interneurons and Perineuronal Nets in a Mouse Model of Schizophrenia

Naielly Rodrigues da Silva, Davide Gobbo, Felipe V. Gomes, Anja Scheller et autres

Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Davide Gobbo, Phillip Rieder, Li‐Pao Fang, Emeline Buttigieg et autres

GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor cells (OPCs) respond to injuries and neurodegenerative diseases like multiple …

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Cannabidiol reverses microglia activation and loss of parvalbumin interneurons and perineuronal nets in a mouse model of schizophrenia

Naielly Rodrigues da Silva, Davide Gobbo, Felipe V. Gomes, Anja Scheller et autres

Abstract Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive, negative, and cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administration of the NMDA receptor antagonist. MK-801 treatment (0.5 …

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Author Correction: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

The original version of this Article contained incorrect graphs in Figure 6h. In the original Figure 6h, the colour coding of the curves in the middle panel (6hpi) and right panel (24hpi) were inadvertently reversed. Specifically, the black curves in these panels …

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Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-evoked systemic inflammation (6 hpi), the plasma level of adenosine quickly increased …

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Genetic ablation of GABA B receptors from oligodendrocyte precursor cells protects against demyelination in the mouse spinal cord

Davide Gobbo, Phillip Rieder, LP Fang, Emeline Buttigieg et autres

Abstract GABAergic signaling and GABA B receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor cells (OPCs) respond to injuries and neurodegenerative diseases …

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