Li‐Pao Fang

Oligodendrocyte precursor cell–neuronal lysosomal pathway: A novel therapeutic target for neurodegenerative diseases

Li‐Pao Fang, Yibo Zhao, Xianshu Bai

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From synaptic gatekeepers to affective-cognitive modulators: The astrocyte D1 receptor–d-serine axis in the prefrontal cortex

Li‐Pao Fang, Frank Kirchhoff

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Sex-Specific Properties of Astrocytes: From Development to Evolutionary Insights

Mariza Bortolanza, Davide Gobbo, Li‐Pao Fang, Anja Scheller et autres

Exploring sex-specific differences in astrocytes has emerged as a vital area of neurobiological research. This research sheds light on how astrocytes in females and males differ in their contribution to neuronal functionality, overall brain health, and various neurological disorders. These cells play …

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Oligodendrocyte precursor cells facilitate neuronal lysosome release

Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao et autres

Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in …

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Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Davide Gobbo, Phillip Rieder, Li‐Pao Fang, Emeline Buttigieg et autres

GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination. Therefore, they are promising targets for studying how spinal oligodendrocyte precursor cells (OPCs) respond to injuries and neurodegenerative diseases like multiple …

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Author Correction: Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

The original version of this Article contained incorrect graphs in Figure 6h. In the original Figure 6h, the colour coding of the curves in the middle panel (6hpi) and right panel (24hpi) were inadvertently reversed. Specifically, the black curves in these panels …

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GPR50 regulates neuronal development as a mitophagy receptor

Ji-Chuan Liu, Xiu‐Yun Zhao, Ming-Lei Wu, Yifan Shi et autres

Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a pivotal role in maintaining mitochondrial quality and quantity. We herein describe that …

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Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Qilin Guo, Davide Gobbo, Na Zhao, Hong Zhang et autres

Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-evoked systemic inflammation (6 hpi), the plasma level of adenosine quickly increased …

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Unlocking the Potential: immune functions of oligodendrocyte precursor cells

Amr Haroon, Harsha Seerapu, Li‐Pao Fang, Jakob Heinrich Weß et autres

Oligodendrocyte precursor cells (OPCs) have long been regarded as progenitors of oligodendrocytes, yet recent advances have illuminated their multifaceted nature including their emerging immune functions. This review seeks to shed light on the immune functions exhibited by OPCs, spanning from phagocytosis to …

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Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases

Li‐Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao et autres

Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through intricate regulatory mechanisms. Here, we observed that OPC processes establish connections with neuronal somata, with smaller lysosomes positioned near these contact sites. Tracking lysosomes demonstrated neuronal lysosomes were attracted to and released at …

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Mass spectrometry imaging combined with isotope tracer technology reveals dynamic metabolic responses of DGNs

Qin Shen, Li‐Pao Fang, Rongcan Luo, Wei Liu

Mass spectrometry imaging combined with isotope tracer technology reveals dynamic

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Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy

Qilin Guo, Davide Gobbo, Na Zhao, Qing Liu et autres

Summary Molecular pathways mediating systemic inflammation entering the brain parenchyma to induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in mice during the first 6 hours of peripheral lipopolysaccharide (LPS)-evoked systemic inflammation (6 hpi), the plasma level of adenosine quickly …

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