Erkang Yi

Nuclear Factor Erythroid 2-Related Factor 2 in Chronic Obstructive Pulmonary Disease Progression: Regulation of Macrophage Polarization and Hyaluronic Acid Metabolism

Ge Bai, Jiaqi Wang, Qianmei Wen, Yuning Huang et autres

Background: Alveolar microenvironment-driven macrophage polarization critically influences chronic obstructive pulmonary disease (COPD) progression. Nuclear factor erythroid 2-related factor 2 (NRF2), a key transcription factor, regulates macrophage polarization, suppresses inflammation, and promotes cellular repair. However, its role in macrophage-mediated inflammation and metabolic regulation, …

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A novel protective role for SULF1 in chronic obstructive pulmonary disease through systemic compensation and binding to KRT15

Yu Liu, Erkang Yi, Yue Xi, Yujie Zuo et autres

This study explores the role of Sulfatase 1 (SULF1) in the progression of Chronic Obstructive Pulmonary Disease (COPD). SULF1, a modifying enzyme involved in various biological processes, was quantified in human serum using ELISA, and its correlation with lung function was analyzed. …

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Single-Nucleus Transcriptomics Reveals Ubiquitin Pathway Dysregulation and Impaired Neuroglial Communication in Chronic Secondhand Smoke-Induced Cognitive Decline

Zongtang Xu, Zhongqiang Su, Fengchu Liang, Han Lin et autres

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A foundational model encodes deep phenotyping data and enables diverse downstream applications

Qiyang Hong, C H U N Q I Wang, Wenqian Wu, Yuyan Li et autres

Deep phenotyping data are essential for understanding disease mechanisms and individual health trajectories. However, its unprecedented scale and complexity pose significant analytical challenges that conventional approaches struggle to address. Here, we introduce ukbFound, a foundation model that encoded thousands of individual-level traits …

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Prognostic Significance of Mild Exacerbations or 1 Moderate Exacerbation in COPD

Fan Wu, Qi Wan, Heshen Tian, Youlan Zheng et autres

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TRPC6 mediates goblet cell differentiation in COPD

Haiqing Li, Guoping Hu, Lizhi Huang, Erkang Yi et autres

BACKGROUND: Goblet cell metaplasia is a pathological feature of airway remodelling in chronic obstructive pulmonary disease (COPD). Basal cell clones with goblet cell metaplasia demonstrate high transient receptor potential cation channel subfamily C member 6 (TRPC6) expression, but its biological function remains …

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Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population

Wenqian Wu, Minyu Zhou, Junye Chen, Jixin Wang et autres

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. COPD is characterized by progressive airflow restriction and wide-spectrum heterogeneity across clinical manifestations, treatment responses, and underlying mechanisms. While recent omics approaches have advanced our understanding of COPD, …

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Multiomics Mendelian randomization identifies serpin family G member 1 as a chronic obstructive pulmonary disease modulator

Erkang Yi, Jieda Cui, Hairong Wang, Fan Wu et autres

Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, lacks effective disease-modifying therapies, partly because of complex gene-environment interactions and extensive missing heritability. Here, we applied a multiomics Mendelian randomization (MR) framework-integrating proteome- and transcriptome-wide association analyses (pQTLs/eQTLs) with …

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Multi-omics reveals cholesterol-driven macrophage metabolic reprogramming and inflammation in chronic obstructive pulmonary disease

Xinru Ran, ZhanDong Yang, Li Cheng, Weidong Li et autres

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disorder with rising global morbidity and mortality. Emerging evidence suggests that systemic metabolic alterations, particularly dyslipidemia, contribute to COPD pathogenesis. However, the mechanisms linking lipid dysregulation to pulmonary inflammation and tissue injury …

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Routine Serum Albumin and Lipids Identify a Systemic High-Risk COPD Phenotype: A Multi-Omics–Derived, Clinically Actionable Framework

Erkang Yi, Huahua Xu, Xiaohui Wu, See PDF

Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD

Xinyue Mei, Junxiang Wang, Yuan Wang, Cheng Li et autres

The mechanisms of the chronic inflammatory response in smoking-induced chronic obstructive pulmonary disease (COPD) remain unclear, with limited understanding of T cell responses to smoke exposure in lung tissue and circulation. We characterized the alterations in T cells associated with smoke exposure …

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Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression

Erkang Yi, Qingyang Li, Wenqian Wu, Chengshu Xie et autres

Chronic obstructive pulmonary disease (COPD) associates with increased lung cancer incidence and shares genetic susceptibility, yet its independent causal role and driver mechanisms are poorly understood. We integrated data from the National Health and Nutrition Examination Survey (NHANES) cohort with genome-wide association …

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