Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD
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Le résumé fourni par la source
The mechanisms of the chronic inflammatory response in smoking-induced chronic obstructive pulmonary disease (COPD) remain unclear, with limited understanding of T cell responses to smoke exposure in lung tissue and circulation. We characterized the alterations in T cells associated with smoke exposure using single-cell RNA sequencing, TCR sequencing, and flow cytometry-based validation. Our experiments show significant recruitment of T cells within the airways, exhibiting a multifaceted immune profile, augmented TCR clonal diversity, and a prolonged CDR3 length. Notably, smoke-induced γδ T cells, particularly clonally expanded γ6δ4 T cells with high Il17a expression, accumulate in smoke-induced airway inflammation. Despite arising in inflammation, these cells function in a protective manner: γδT17 deficiency worsens smoke-induced lung injury, whereas adoptive transfer of γδT17 cells restores tissue protection in smoke-exposed lungs over time. Here, we show γδT17 cells as a potential target for addressing smoke-induced immune dysfunctions, providing alternative avenues for early prevention and treatment of COPD. T cells have been shown to have a function in chronic lung inflammation in COPD. Here the authors characterise the single cell transcriptional profile of T cells after smoke inhalation in mouse models showing changes in TCR repertoire and Il17a expression in γδ T cells, suggesting smoke-associated γδ T cells are involved in COPD inflammation and implicating γδT17 cells as a possible target for early prevention and treatment of COPD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD
- Date Crossref
- 08/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease pays non établi dans la noticeÉtablissement de santé
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State Key Laboratory of Respiratory Disease pays non établi dans la noticeStructure de recherche
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Guangzhou Institute of Respiratory Health pays non établi dans la noticeStructure de recherche
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Guangzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
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Hainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou National Laboratory pays non établi dans la noticeStructure de recherche
State Key Laboratory of Respiratory Disease — First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease et Guangzhou Institute of Respiratory Health, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.