2026
conference-abstract
OpenAlex
Kaitlyn M. Landreth, Katherine Lee, Emel Sen Kilic, Joshua A. Chapman et autres
Abstract Immunotherapies have become standard of care in the treatment of melanoma; however, about 50% of patients are immunotherapy resistant. This can be caused by an immunosuppressive tumor microenvironment that has a low infiltration of immune cells, especially T cells. Tumors with …
us
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2025
article
OpenAlex
Lillie M. Powell, Soo Jeon Choi, Lei Wang, Gangqing Hu et autres
ABSTRACT Macrolide-resistant emm92 -type invasive Streptococcus pyogenes has emerged in the United States since 2010, posing the question of whether acquired erm (T)-encoded resistance may have contributed to the rise in infections. Here, we present the transcriptomes for two Streptococcus pyogenes isolates …
us
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2025
article
OpenAlex
Katherine S. Lee, Dylan T. Boehm, Nathaniel A. Rader, Melissa Cooper et autres
Abstract Description Despite advancements in vaccine technology that improve efficacy, many vaccines only confer short-lived immunity. Vaccine formulations can be improved using adjuvants that increase inflammation and elicit specific immune activation profiles. To identify immunological signatures of the immune response to COVID-19 …
us
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2025
article
OpenAlex
Annalisa Bison Huckaby, María de la Paz Gutierrez, Carleena Marie Rocuskie Marker, Spencer R. Dublin et autres
Abstract Description Lyme Disease (LD) is the number one tick-borne disease in the U.S., with an estimated incidence rate of at minimum 60,000 individuals each year. In the U.S., LD is caused by the gram-negative spirochete B. burgdorferi (Bb) and is transmitted …
us
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2025
article
OpenAlex
Carleena Marie Rocuskie Marker, Annalisa Bison Huckaby, Gage Michael Pyles, María de la Paz Gutierrez et autres
Abstract Description Lyme disease (LD), caused by Borrelia burgdorferi, leads to an estimated 476,000 cases annually in the U.S. Furthermore, the presence of nonspecific LD symptoms frequently results in misdiagnosis and delayed treatment. Although LYMErix® showed initial promise with an rOspA vaccine …
us
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2025
article
OpenAlex
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet et autres
ABSTRACT Background Advancing age increases cancer risk due to DNA damage accumulation and a decline in immune function. While aging is known to reduce adaptive immunity, it also leads to an increase in immunosuppressive myeloid cells, which promote tumor progression and are …
us
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2025
article
OpenAlex
Katherine S. Lee, Dylan T. Boehm, Olivia A. Miller-Stump, Nathaniel A. Rader et autres
Hypertension, diabetes, and obesity are comorbidities that influence severe cases of COVID-19 and are associated with weak humoral immunity after vaccination. We hypothesized that the diet-induced obese (DIO) K18-hACE2 mouse model could be utilized to reveal sex and DIO- specific differences in …
us
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2025
preprint
OpenAlex
Christopher L. Pritchett, Fredrick Heath Damron, Mariette Barbier
Abstract Pseudomonas aeruginosa (Pa) is an important opportunistic pathogen that has many virulence factors expressed in a coordinated manner to cause infection. External appendages, such as the type IV pili (T4P), can be used for signal transduction changing gene expression using a …
us
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2025
article
OpenAlex
Angisha Basnet, Dylan D. Thomas, Kaitlyn M. Landreth, Fredrick Heath Damron et autres
PURPOSE: Imaging reporters have been widely employed in cancer research to monitor real-time tumor burden and metastatic spread. These tools offer a valuable approach for non-invasive imaging of tumor dynamics over time. With the established understanding that tumor immunology plays a critical …
us
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2025
article
OpenAlex
Dylan T. Boehm, Kaitlyn M. Landreth, Emel Sen-Kilic, Katherine S. Lee et autres
Immunotherapies are effective for cancer treatment but are limited in ‘cold’ tumor microenvironments due to a lack of infiltrating CD8 + T cells, key players in the anti-cancer immune response. The onset of the COVID-19 pandemic sparked the widespread use of mRNA-formulated …
us, fr
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Accès ouvert
2024
article
OpenAlex
Margalida Mateu-Borrás, Spencer R. Dublin, Jason H. Kang, Hunter L. Monroe et autres
ABSTRACT The incidence of infections attributed to antimicrobial-resistant (AMR) pathogens has increased exponentially over the recent decades reaching 1.27 million deaths worldwide in 2019. Without intervention, these infections are predicted to cause up to 10 million deaths a year and incur costs …
us
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2024
article
OpenAlex
María de la Paz Gutierrez, Fredrick Heath Damron, Federico Sisti, Julieta Fernández
ABSTRACT Bordetella bronchiseptica is a pathogenic bacterium that causes respiratory infections in mammals. Adhesins, toxins, and secretion systems necessary for infection are regulated by the two-component system BvgAS. When the BvgAS system is inactive, there is no transcription of virulence-activated genes, and …
ar, us
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