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2026
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OpenAlex
Annalisa Bison Huckaby, María de la Paz Gutierrez, Ching Wooen Sze, Barrett-Anne Briggs et autres
ABSTRACT Lyme disease is a tick-borne disease caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Murine models of B. burgdorferi infection allows for the assessment of bacterial dissemination and presence through culture of infected tissue and dark-field microscopic examination after …
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2026
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OpenAlex
Carleena M. Rocuskie-Marker, Annalisa Bison Huckaby, Olivia Conaway, Gage Michael Pyles et autres
Lyme disease (LD) is the most prevalent vector-borne disease in the United States, impacting ∼476,000 individuals annually with increasing incidence. Prevention relies on personal protective measures such as insecticides and tick checks, underscoring the need for new preventatives such as vaccines. In …
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2025
article
OpenAlex
Nathaniel A. Rader, Dylan T. Boehm, Melissa Cooper, Casey C. Cunningham et autres
Abstract Description Children routinely receive COVID-19 mRNA vaccines alongside other regularly scheduled immunizations. It is known that mRNA vaccines are pro-inflammatory in nature which lead to protective immunity. Our goal was to investigate the effects of co-administering the COVID-19 mRNA vaccine alongside …
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2025
article
OpenAlex
Annalisa Bison Huckaby, María de la Paz Gutierrez, Carleena Marie Rocuskie Marker, Spencer R. Dublin et autres
Abstract Description Lyme Disease (LD) is the number one tick-borne disease in the U.S., with an estimated incidence rate of at minimum 60,000 individuals each year. In the U.S., LD is caused by the gram-negative spirochete B. burgdorferi (Bb) and is transmitted …
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2025
article
OpenAlex
Spencer R. Dublin, Samuel Ulicny, Annalisa Bison Huckaby, William T. Witt et autres
Abstract Description Pseudomonas aeruginosa is a ubiquitous, opportunistic Gram-negative pathogen. It is a prevalent hospital-acquired pathogen, and possesses multi-drug resistance (MDR), resulting in difficult to treat infections. The CDC has highlighted the need for novel strategies to combat these MDR strains of …
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2025
article
OpenAlex
Carleena Marie Rocuskie Marker, Annalisa Bison Huckaby, Gage Michael Pyles, María de la Paz Gutierrez et autres
Abstract Description Lyme disease (LD), caused by Borrelia burgdorferi, leads to an estimated 476,000 cases annually in the U.S. Furthermore, the presence of nonspecific LD symptoms frequently results in misdiagnosis and delayed treatment. Although LYMErix® showed initial promise with an rOspA vaccine …
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2025
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OpenAlex
Aziza Frank, Lucia Hwang, William T. Witt, Garrick Centola et autres
Multidrug-resistant Pseudomonas aeruginosa is a critical pathogen that demands new antibiotics. During P. aeruginosa infection, the extracellular hemophore hasAp and its outer membrane receptor hasR are the most dramatically upregulated genes. The P. aeruginosa Δ hasR strain exhibits significantly reduced growth and …
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2024
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OpenAlex
Margalida Mateu-Borrás, Spencer R. Dublin, Jason H. Kang, Hunter L. Monroe et autres
ABSTRACT The incidence of infections attributed to antimicrobial-resistant (AMR) pathogens has increased exponentially over the recent decades reaching 1.27 million deaths worldwide in 2019. Without intervention, these infections are predicted to cause up to 10 million deaths a year and incur costs …
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2024
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OpenAlex
Gage Michael Pyles, Annalisa Bison Huckaby, María de la Paz Gutierrez, William T. Witt et autres
ABSTRACT Bordetella pertussis, the bacterium responsible for whooping cough, remains a significant public health challenge despite the existing licensed pertussis vaccines. Current acellular pertussis vaccines, though having favorable reactogenicity and efficacy profiles, involve complex and costly production processes. In addition, acellular vaccines …
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2024
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OpenAlex
Graham J. Bitzer, Nicholas A. Fitzgerald, Megan A. DeJong, Casey C. Cunningham et autres
ABSTRACT Bordetella pertussis is a Gram-negative bacterium that is the causative agent of the respiratory disease known as pertussis. Since the switch to the acellular vaccines of DTaP and Tap, pertussis cases in the US have risen and cyclically fallen. We have …
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2024
article
OpenAlex
María de la Paz Gutierrez, Annalisa Bison Huckaby, Evita Yang, Kelly L. Weaver et autres
Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most common tick-borne illness in the United States. Despite the rise in Lyme disease incidence, there is no vaccine against B. burgdorferi approved for human use. Little is known about the immune …
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Accès ouvert
2024
article
OpenAlex
Megan A. DeJong, M. Allison Wolf, Graham J. Bitzer, Jesse M. Hall et autres
ABSTRACT The protection afforded by acellular pertussis vaccines wanes over time, and there is a need to develop improved vaccine formulations. Options to improve the vaccines involve the utilization of different adjuvants and administration via different routes. While intramuscular (IM) vaccination provides …
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