Emel Sen-Kilic

Development of a Low-Cost UAS Air Sampler for Multi-Point Aerosol Collection

Avinash Muthu Krishnan, Kevin A. Adkins, Marc D. Compere, David Zink et autres

This work describes the development of a low-cost uncrewed aircraft system (UAS)-mounted air sampler for collecting multiple discrete aerosol samples during a single flight. The system uses a liquid impinger approach in which ambient air is drawn through a collection liquid to …

Session 5: Sensors I

Kevin A. Adkins, Melanie Kobras, Byron Drew, Brad Guay et autres

Session 5: Sensors I

Session 7: New Observations II

Dr. James Pinto, Joseph J. Cione, Joshua B. Wadler, Jun A. Zhang et autres

Session 7: New Observations II

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Development of an Uncrewed Aircraft Water Sampler

Justin Fratto, Marc D. Compere, Avinash Muthu Krishnan, David Zink et autres

Harmful algal blooms (HABs) are abundant in many regions of South Florida and produce toxins that pose significant health concerns for wildlife and surrounding human communities. Often blooming in warmer months due to a variety of environmental and anthropogenic factors, HABs can …

The Role of the Pseudomonas aeruginosa Heme Metabolites Biliverdin IXβ and IXδ in Pathogenesis and Infection

Susana Mouriño, Saba Shahzad, Weiliang Huang, Mehari Weldemariam et autres

Pseudomonas aeruginosa utilizes heme as a major source of iron in the host. The transition to chronic infection coincides with the switch from iron-siderophore uptake to heme utilization. We have shown that the bacterial heme metabolites BVIXβ and BVIXδ are signaling molecules …

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Development of a fluorescent reporter strain to facilitate studies of Borrelia burgdorferi pathogenesis

Annalisa Bison Huckaby, María de la Paz Gutierrez, Ching Wooen Sze, Barrett-Anne Briggs et autres

ABSTRACT Lyme disease is a tick-borne disease caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Murine models of B. burgdorferi infection allows for the assessment of bacterial dissemination and presence through culture of infected tissue and dark-field microscopic examination after …

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Chemokine responses to mRNA vaccination reveal targets for novel genetic adjuvant strategies 3045

Katherine S. Lee, Dylan T. Boehm, Nathaniel A. Rader, Melissa Cooper et autres

Abstract Description Despite advancements in vaccine technology that improve efficacy, many vaccines only confer short-lived immunity. Vaccine formulations can be improved using adjuvants that increase inflammation and elicit specific immune activation profiles. To identify immunological signatures of the immune response to COVID-19 …

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Co-administration of DTaP and mRNA COVID-19 vaccines results in altered immune profile and enhanced protection against aerosol challenge of B. pertussis in mice 3042

Nathaniel A. Rader, Dylan T. Boehm, Melissa Cooper, Casey C. Cunningham et autres

Abstract Description Children routinely receive COVID-19 mRNA vaccines alongside other regularly scheduled immunizations. It is known that mRNA vaccines are pro-inflammatory in nature which lead to protective immunity. Our goal was to investigate the effects of co-administering the COVID-19 mRNA vaccine alongside …

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Sequencing-driven identification of immunotherapeutics for treatment of Lyme disease 4155

Annalisa Bison Huckaby, María de la Paz Gutierrez, Carleena Marie Rocuskie Marker, Spencer R. Dublin et autres

Abstract Description Lyme Disease (LD) is the number one tick-borne disease in the U.S., with an estimated incidence rate of at minimum 60,000 individuals each year. In the U.S., LD is caused by the gram-negative spirochete B. burgdorferi (Bb) and is transmitted …

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Monoclonal therapeutic antibody synergizes with antibiotics to promote clearance of Pseudomonas aeruginosa 3062

Spencer R. Dublin, Samuel Ulicny, Annalisa Bison Huckaby, William T. Witt et autres

Abstract Description Pseudomonas aeruginosa is a ubiquitous, opportunistic Gram-negative pathogen. It is a prevalent hospital-acquired pathogen, and possesses multi-drug resistance (MDR), resulting in difficult to treat infections. The CDC has highlighted the need for novel strategies to combat these MDR strains of …

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Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet et autres

ABSTRACT Background Advancing age increases cancer risk due to DNA damage accumulation and a decline in immune function. While aging is known to reduce adaptive immunity, it also leads to an increase in immunosuppressive myeloid cells, which promote tumor progression and are …

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GaSal-2: A Water-Soluble Antipseudomonal Agent Targeting the Extracellular Hemophore HasAp

Aziza Frank, Lucia Hwang, William T. Witt, Garrick Centola et autres

Multidrug-resistant Pseudomonas aeruginosa is a critical pathogen that demands new antibiotics. During P. aeruginosa infection, the extracellular hemophore hasAp and its outer membrane receptor hasR are the most dramatically upregulated genes. The P. aeruginosa Δ hasR strain exhibits significantly reduced growth and …

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