Annika Karger

IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition

Siavash Mansouri, Golnaz Hesami, Anoop Ambikan, Annika Karger et autres

Tumor-associated macrophages (TAMs) possess both tumor-promoting and tumor-inhibiting roles. Here, we explore TAMs' anti-tumor functions, focusing on the immune responsive gene 1 (IRG1) and its product, itaconate, in lung cancer development. Spatial metabolomics reveals that endogenous itaconate is markedly depleted within lung …

de, se, nl, at, us (code pays fourni par la source)

Living human lung slices for ex vivo modelling of lung cancer

Siavash Mansouri, Annika Karger, Clemens Ruppert, Marc A. Schneider et autres

The tumor microenvironment (TME) markedly affects cancer progression, yet traditional animal models do not fully recapitulate the situation in humans. To address this, we developed tumor-derived precision lung slices (TD-PCLS), an ex vivo platform for studying the lung TME and evaluating therapies. …

de, ru, ca (code pays fourni par la source)

Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh et autres

Abstract Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB signaling pathway modulates metastasis-associated …

Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh et autres

Abstract Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB signaling pathway modulates metastasis-associated …

Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh et autres

Supplementary text, tables and figures

Supplementary Data from Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh et autres

Supplementary text, tables and figures

ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

Annika Karger, Siavash Mansouri, Matthias S. Leisegang, Andreas Weigert et autres

Long noncoding RNAs (lncRNAs) influence the transcription of gene networks in many cell types, but their role in tumor‐associated macrophages (TAMs) is still largely unknown. We found that the lncRNA ADPGK‐AS1 was substantially upregulated in artificially induced M2‐like human macrophages, macrophages exposed …

de (code pays fourni par la source)

Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression

Annika Karger, Rajender Nandigama, Albrecht Stenzinger, Friedrich Grimminger et autres

Ever since RNA sequencing of whole genomes and transcriptomes became available, numerous RNA transcripts without having the classic function of encoding proteins have been discovered. Long non-coding RNAs (lncRNAs) with a length greater than 200 nucleotides were considered as "junk" in the …

de (code pays fourni par la source)

MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival

Susanne Bacher, Hilda Stekman, Carla M. Farah, Annika Karger et autres

Cullin-4 ubiquitin ligase (CRL4) complexes are differentially composed and highly dynamic protein assemblies that control many biological processes, including the global genome nucleotide excision repair (GG-NER) pathway. Here, we identified the kinase mitogen-activated protein kinase kinase kinase 1 (MEKK1) as a novel …

de (code pays fourni par la source)

Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation

Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh et autres

Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB signaling pathway modulates metastasis-associated protein …

de, hu, ru, fr (code pays fourni par la source)

Long non-coding RNA ADPGK-AS1 controls anti-tumor immunity in macrophages through metabolic modulation

Annika Karger, Matthias S. Leisegang, Siavash Mansouri, Carsten Kuenne et autres

Recent evidences suggest that tumor-associated macrophages (TAMs) metabolism plays a crucial role on TAM activation, lung tumor progression and metastasis. However, the molecular pathways underlying this regulation still need to be explored. This study analyzes the role of the long non-coding RNA …

de (code pays fourni par la source)

Epithelial cell plasticity defines heterogeneity in lung cancer

Poonam Sarode, Siavash Mansouri, Annika Karger, Martina Barbara Schaefer et autres

de (code pays fourni par la source)