Marc A. Schneider

Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma

Ujjwal Neogi, Anoop T. Ambikan, Kati Turkowski, Marc A. Schneider et autres

Lung adenocarcinoma (LUAD) is a biologically and clinically heterogeneous disease that poses a major challenge for prognosis and treatment. In this study, we performed proteomic profiling in a cohort of 88 LUAD patients to identify molecular subgroups and investigate their clinical relevance. …

se, de, us, ca (code pays fourni par la source)

A Plasma Proteomics Test Predicts Immunotherapy Benefit in NSCLC Independent of Genomic Alterations

Orit Itzhaki, Michal Harel, Petros Christopoulos, Marc A. Schneider et autres

il, us (code pays fourni par la source)

Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: results of the NEOMUN trial

Martin Eichhorn, Benedikt Niedermaier, Pornpimol Charoentong, Laura V. Klotz et autres

BACKGROUND: The phase II NEOMUN trial was conducted to investigate the therapeutic effect of preoperative programmed death receptor-1 inhibitor pembrolizumab for treating non-small cell lung cancer (NSCLC). Herein, we report the final efficacy, safety, and long-term survival results. METHODS: Patients with resectable …

de (code pays fourni par la source)

Living human lung slices for ex vivo modelling of lung cancer

Siavash Mansouri, Annika Karger, Clemens Ruppert, Marc A. Schneider et autres

The tumor microenvironment (TME) markedly affects cancer progression, yet traditional animal models do not fully recapitulate the situation in humans. To address this, we developed tumor-derived precision lung slices (TD-PCLS), an ex vivo platform for studying the lung TME and evaluating therapies. …

de, ru, ca (code pays fourni par la source)

Evaluating the Safety of Delaying Surgery Beyond 9 Months in Localized Prostate Cancer Patients: Results From a Prospective Study With Propensity Score Matching

Maxime Pattou, Y. Neuzillet, T. Ghoneim, Pierre‐Olivier Bosset et autres

OBJECTIVES: The optimal timing of radical prostatectomy (RP) after prostate cancer diagnosis is controversial, particularly concerning the impact of surgical delays on oncological outcomes. While active surveillance is standard for low-risk prostate cancer, the effects of delaying surgery in intermediate- and high-risk …

fr (code pays fourni par la source)

CO2.3 - Incorporating multiple imputation and resampling methods to construct a predictive model for survival outcomes in Muscle-Invasive Bladder Cancer and evaluate the added prognostic value of C-Reactive Protein in the COBLAnCE Cohort

Stefan Michiels, M. Karimi, L. Paper, J. Bonastre et autres

fr (code pays fourni par la source)

Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer

Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Magdalena Görtz et autres

BACKGROUND: Outcomes under anti-PD-(L)1 therapy have been variable in advanced non-small cell lung cancer (NSCLC) without reliable predictive biomarkers so far. Targeted next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) has demonstrated potential clinical utility to support clinical decisions, but requires prior …

de (code pays fourni par la source)

P561 – The added prognostic value of C-reactive protein to the 2021 EAU risk classification in patients with non-muscle invasive bladder cancer in the COBLAnCE cohort

L. Paper, J. Bonastre, T. Lebret, Y. Neuzillet et autres

Intratumor Heterogeneity Predicts Prognosis in Lepidic Predominant Lung Adenocarcinoma

Benedikt Niedermaier, Michael Allgäuer, Thomas Muley, Marc A. Schneider et autres

OBJECTIVE: Among the different subtypes of invasive lung adenocarcinoma, lepidic predominant adenocarcinoma (LPA) has been recognized as the lowest-risk subtype with good prognosis. The aim of this study is to provide insight into the heterogeneity within LPA tumors and to better understand …

de (code pays fourni par la source)

Prognostic Impact of Lepidic Growth in Intermediate and High-Grade Lung Adenocarcinoma

Benedikt Niedermaier, Erik Rolf, Michael Allgäuer, Laura V. Klotz et autres

de (code pays fourni par la source)

P276 The added prognostic value of C-Reactive Protein to a clinicopathological prediction model for survival outcomes in patients with muscle invasive bladder cancer in the COBLAnCE cohort

L. Paper, J. Bonastre, T. Lebret, Y. Neuzillet et autres

Final Results of the ANDROCAN Study: Histopathological Characteristics and Biochemical Recurrence at 5 Years of Localized Prostate Cancer According to Preoperative Gonadal Status

Y. Neuzillet, Jean‐Pierre Raynaud, Jean‐François Dreyfus, C. Radulescu et autres

fr, mq (code pays fourni par la source)