Clemens Ruppert

Vascular smooth muscle cell–derived osteoprotegerin drives pulmonary arterial hypertension via AKT activation and is attenuated by monoclonal antibody therapy

Merve Keleş, Laura West, Nadine Arnold, Astrid Weiß et autres

AIM: Pulmonary arterial hypertension (PAH) is driven by sustained vasoconstriction and structural remodelling of distal pulmonary arteries. We have previously demonstrated that osteoprotegerin (OPG, tnfrsf11b) is upregulated in PAH animal models and patient tissues, with circulating levels being prognostic. OPG knockout mice …

us, gb, de (code pays fourni par la source)

“Do not eat me’’: LILRB4 signaling as a novel macrophage immunotherapy in lung cancer 2254327

Spyridoula Barmpoutsi, Poonam Sarode, Kati Turkowski, Siavash Mansouri et autres

Abstract Introduction Lung cancer is the leading cause of cancer-related deaths. Although current T cell-targeting immunotherapies have improved patient survival, the efficacy is still low. Today, macrophage-mediated immune escape via “do not eat me” signaling is brought to light. The leukocyte immunoglobulin-like …

de (code pays fourni par la source)

IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition

Siavash Mansouri, Golnaz Hesami, Anoop Ambikan, Annika Karger et autres

Tumor-associated macrophages (TAMs) possess both tumor-promoting and tumor-inhibiting roles. Here, we explore TAMs' anti-tumor functions, focusing on the immune responsive gene 1 (IRG1) and its product, itaconate, in lung cancer development. Spatial metabolomics reveals that endogenous itaconate is markedly depleted within lung …

de, se, nl, at, us (code pays fourni par la source)

Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts

Wolfgang Merkt, Lea Rodon, Franca S. Deicher, Merle Freitag et autres

Impaired immune clearance of senescent fibroblasts is a putative driver of pulmonary fibrosis. Exhausted natural killer (NK) cells have been implicated in this process, yet the underlying immune evasion mechanisms remain poorly understood. Using single-cell RNA sequencing (scRNA-seq) and spectral flow cytometry, …

de, us, it (code pays fourni par la source)

C-type natriuretic peptide – cyclic GMP Axis in Pulmonary Fibrosis: From Disease Mechanisms to Therapeutic Targeting

Swati Dabral, Rene Weyer, Tamara Potapenko, Lisa Krebes et autres

Pulmonary fibrosis (PF) is a progressive, often fatal lung disease with limited therapeutic options. Its pathogenesis is driven by inflammatory infiltration and fibroblast-to-myofibroblast transition, resulting in excessive extracellular matrix deposition. While profibrotic pathways are well characterized, endogenous counter-regulatory mechanisms remain poorly understood. …

de, us (code pays fourni par la source)

Targeting fused in sarcoma (FUS): a novel antisense strategy for treating idiopathic pulmonary fibrosis

Bhavika Katariya, Shashi Chillappagari, Lisa Arnold, Stefan Guenther et autres

Fused in sarcoma (FUS) is a highly conserved RNA-binding protein with essential roles in RNA processing and genomic stability. While extensively studied in the context of neurodegeneration, its involvement in fibrotic diseases, particularly idiopathic pulmonary fibrosis (IPF), remains largely unexplored. This study …

de, ru, at, us (code pays fourni par la source)

RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices

Poornima Mahavadi, Martina Korfei, Christin Müller, Clemens Ruppert et autres

BACKGROUND: R) blockers (ARB) is much less clear. We evaluated the effects of the ACEi enalapril (ENA) and the ARB losartan (LOS) on SARS-CoV-2 infection in human ex vivo-cultured, precision-cut lung slices (PCLS) obtained from normal human lung tissue. METHODS: PCLS were …

de, fr (code pays fourni par la source)

Pathophysiological and therapeutic implications of C-type natriuretic peptide/cyclic GMP signaling in pulmonary fibrosis

R. Vande Weyer, Katharina Völker, Tamara Potapenko, Lisa Krebes et autres

Activation of lung fibroblasts in response to epithelial injury and inflammation provokes pulmonary fibrosis (PF). Endogenous molecular brakes counteracting fibroblast activity can be targets for therapies. Preclinical studies of synthetic C-type natriuretic peptide (CNP) indicated that this hormone might provide such a …

de, us (code pays fourni par la source)

RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices

Poornima Mahavadi, Martina Korfei, Christin Müller, Clemens Ruppert et autres

Background: While the renin-angiotensin-aldosterone system (RAAS) is critically involved in pathomechanisms related to SARS-CoV-2 infection, the role of ongoing therapy with angiotensin-converting enzyme 1 inhibitors (ACEi) or Angiotensin-II type 1 receptor (AT1R) blockers (ARB) is much less clear. We evaluated the effects …

Interleukin-27 orchestrates lymphocyte responses and disease severity during Legionella infection in the lung 2083

Markus Bosmann, Johannes Platten, Sarah Walachowski, Archana Jayaraman et autres

Abstract Description Legionnaires’ disease (LD) is a severe respiratory illness caused by Legionella spp., with a 7-10% fatality rate in the US and limited knowledge of its pathobiology. Interleukin (IL)-27 is an immunomodulatory cytokine that signals through the IL-27RA and gp130 receptors. …

de, us, at, cz, br (code pays fourni par la source)

KCTD12 redox state as a determinant and therapeutic target in pulmonary remodeling

Daniel Simões de Jesus, Rebecca L. Charles, Asvi Francois, Micol Falabella et autres

gb, de (code pays fourni par la source)

Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension

Yunhye Kim, Giovanni Maroli, Chen-Shan Chen Woodcock, Hyunbum Kim et autres

BACKGROUND: ADAR1 (adenosine deaminase acting on RNA 1) catalyzes the conversion of adenosine to inosine in double stranded RNAs (dsRNAs), which is critical to prevent autoinflammatory responses mediated by activation of the type I IFN (interferon) signaling. We define the role of …

us, de, gb, fr (code pays fourni par la source)