Olov Sterner

Pulcaffeate, a Trimeric Caffeic Acid Derivative from Bourreria pulchra

Gilda J. Erosa-Rejón, Alejandro Yam-Puc, Luis M. Peña-Rodrı́guez, Olov Sterner

Abstract. The trimeric caffeic acid derivative pulcaffeate (1) was isolated from the organic crude extract of the roots of Bourreria pulchra (Boraginaceae). The biosynthesis of 1 appears to involve an intramolecular Diels-Alder reaction between a cyclohexa-1,3-diene intermediate, generated by the oxidation of …

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Cytotoxic and other bioactivities of a novel and known sesquiterpene lactones isolated from Vernonia leopoldi (Sch. Bip. ex Walp.) Vatke in breast cancer cell lines

Nigatu Tuasha, Zilma Escobar, Daniel Seifu, Endalamaw Gadisa et autres

(Sch. Bip. ex Walp.) Vatke (Asteraceae) is one of the widely used anti-cancer traditional medicinal plants in Ethiopia, despite the lack of data to support its therapeutic efficacy. Here we describe the isolation of compounds from the plant and the investigation of …

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Curcuma as an adjuvant in colorectal cancer treatment

Cecilia Villegas, Rebeca Pérez, Olov Sterner, Iván González‐Chavarría et autres

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SARs for the Antiparasitic Plant Metabolite Pulchrol. 3. Combinations of New Substituents in A/B-Rings and A/C-Rings

Paola Terrazas, Efraín Salamanca, Marcelo Dávila, Sophie Manner et autres

The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess antiparasitic activity towards Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, which are protozoa responsible for Chagas disease and leishmaniasis. These …

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Trichilones A–E: New Limonoids from Trichilia adolfi

Mariela González-Ramírez, Ivan Limachi, Sophie Manner, Juan Carlos Ticona et autres

In addition to the trichilianones A–D recently reported from Trichilia adolfi, a continuing investigation of the chemical constituents of the ethanol extract of the bark of this medicinal plant yielded the five new limonoids 1–5. They are characterized by having four fused …

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Trichilianones A-D, Novel Cyclopropane-Type Limonoids from Trichilia adolfi

Ivan Limachi, Mariela González-Ramírez, Sophie Manner, Juan Carlos Ticona et autres

The fractionation of an ethanol extract of the bark of Trichilia adolfi yielded four novel limonoids (trichilinones A-D, 1–4), with five fused rings and related to the hortiolide-type limonoids. Starting with an ε-lactone, which is α,β-unsaturated in trichilinones A and D (1 …

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Steroidal glycosides from Caralluma pauciflora

Sridhar Babu Gummadi, Belvotagi Venkatrao Adavi Rao, Devendar Reddy Kommidi, Ravi Kumar Bobbala et autres

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SARs for the Antiparasitic Plant Metabolite Pulchrol. Part 2: B- and C-Ring Substituents

Paola Terrazas, Sophie Manner, Olov Sterner, Marcelo Dávila et autres

Neglected tropical diseases affect most of the underprivileged populations in tropical countries. Among these are chagas and leishmaniasis, present mainly in South and Central America, Africa and East Asia. Current treatments are long and have severe adverse effects, therefore there is a …

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SAR:s for the Antiparasitic Plant Metabolite Pulchrol. 1. The Benzyl Alcohol Functionality

Paola Terrazas, Efraín Salamanca, Marcelo Dávila, Sophie Manner et autres

Pulchrol (1) is a natural benzochromene isolated from the roots of Bourreria pulchra, shown to possess potent antiparasitic activity towards both Leishmania and Trypanozoma species. As it is not understood which molecular features of 1 are important for the antiparasitic activity, several …

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Stereoretentive Nucleophilic Substitution at the Tetrasubstituted Carbon of Galiellalactone

Zilma Escobar, Jakob Nilsson, Ritha Gidlöf, Martin Johansson et autres

, discovered to undergo a substitution reaction with cysteine derivatives. By studying the reaction mechanism and the intermediates formed, and in an effort to expand the chemical diversity of the galiellalactonoids, a mild and general method of preparing ether, thioether, and amine …

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Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans

Olena P. Ishchuk, Olov Sterner, Ulf Ellervik, Sophie Manner

The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. albicans from yeast-form cells to cells forming …

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Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of Candida albicans

Olena P. Ishchuk, Olov Sterner, Ulf Ellervik, Sophie Manner

Abstract The opportunistic human fungal pathogen Candida albicans rely on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. albicans from yeast-form cells to cells …

se (code pays fourni par la source)