Paolo Guazzi

Investigating the Effect of Ginger‐Derived Nanovesicles on the Growth and Metabolic Activity of Bacteroides thetaiotaomicron : An Isothermal Microcalorimetric Study

Francesca Loria, Anna Kattel, Marina Junusova, Marco Brucale et autres

ABSTRACT Plant‐derived extracellular vesicles (EVs) have shown numerous health benefits, including modulation of the human gut microbiota. Herein, we employed isothermal microcalorimetry (IMC) to explore the effects of ginger‐derived nanovesicles (G‐NVs) on the growth and metabolic activity of Bacteroides thetaiotaomicron (Bt) , …

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Unveiling a Novel Molecular Interaction and Pro-Metastatic Signaling Cascades Driven by KRIT1

Lucrezia Paradisi, Paolo Guazzi, Matteo Macis, Francesca Finetti et autres

K-Rev Interaction Trapped protein-1 (KRIT1) is a scaffold protein that forms functional protein complexes involved in physiologically important signaling networks. While it is primarily recognized for its association with Cerebral Cavernous Malformations (CCMs), KRIT1 may also play critical roles in tumor formation …

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Investigating the effect of ginger-derived nanovesicles on the growth and metabolic activity of Bacteroides thetaiotaomicron : an isothermal microcalorimetric study

Francesca Loria, Anna Kattel, Marco Brucale, Francesco Valle et autres

Abstract Plant-derived extracellular vesicles (EVs) have shown numerous health benefits, including modulation of the human gut microbiota. Hereby, we employed isothermal microcalorimetry (IMC) to explore the effects of ginger-derived nanovesicles (G-NVs) on the growth and metabolic activity of Bacteroides thetaiotaomicron (Bt), a …

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Spotlight on innovation: key insights from the extracellular vesicle cluster meeting at the European Innovation Council

Giorgia Adamo, Ioannis Amarantos, Iordanis Arzimanoglou, Paolo Bergese et autres

The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, …

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Small and Large Extracellular Vesicles From Human Preovulatory Follicular Fluid Display Distinct ncRNA Cargo Profiles and Differential Effects on KGN Granulosa Cells

Inge Varik, Katariina Johanna Saretok, Kristine Rosenberg, Ileana B. Quintero et autres

Follicular fluid extracellular vesicles (FF EVs) facilitate communication between oocytes and somatic cells within the ovarian follicle, playing a pivotal role in follicular development. This study highlights the molecular and functional distinctions between small (SEV) and large (LEV) FF EV subpopulations, revealing …

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Small and large extracellular vesicles from human preovulatory follicular fluid display distinct ncRNA cargo profile and differential effect on granulosa cell line KGN

Inge Varik, Katariina Johanna Saretok, Kristine Rosenberg, Ileana B. Quintero et autres

ABSTRACT Follicular fluid extracellular vesicles (FF EVs) facilitate communication between oocytes and somatic cells within the ovarian follicle, playing a pivotal role in follicular development. This study highlights the molecular and functional distinctions between small (SEV) and large (LEV) FF EV subpopulations, …

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A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles

Jekaterina Nebogatova, Heleri Heike Härk, Anett Puskar, Ly Porosk et autres

The low bioavailability and high toxicity of plasmid DNA (pDNA)-based therapeutics pose challenges for their in vivo application. Extracellular vesicles (EVs) have great potential to overcome these limitations, as they are biocompatible native cargo carriers. Various methods for loading pDNA into EVs, …

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A method for using the cell-penetrating peptides for loading plasmid DNA into secreted extracellular vesicles

Jekaterina Nebogatova, Heleri Heike Härk, Anett Puskar, Ly Porosk et autres

Abstract The low bioavailability and high toxicity of pDNA-based therapeutics make their application in vivo challenging. Extracellular vesicles (EVs) have great potential to overcome those limitations, thus they are biocompatible native cargo carriers. Various strategies to load EVs with pDNA, such as …

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G-protein binding features and regulation of the RalGDS family member, RGL2

David Magrini, Thomas Fischer, Gilbert White, Lorenza Trabalzini et autres

RGL2 [RalGDS (Ral guanine nucleotide dissociation stimulator)-like 2] is a member of the RalGDS family that we have previously isolated and characterized as a potential effector for Ras and the Ras analogue Rap1b. The protein shares 89% sequence identity with its mouse …

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TM9SF4 expression in tumor tissues: a novel diagnostic biomarker for gastrointestinal tumors

Paolo Guazzi, Davide Zocco, Sergejs Isajevs, Nataša Zarovni et autres

Background: The identification of novel biomarkers for the early detection and monitoring of gastric (GC) and colorectal cancer (CRC) is of paramount importance. TM9SF4 is a newly described V-ATPase interacting protein involved in the malignant progression of cancer cells. While TM9SF4 expression …

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Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology ( SIONCOV ) retrospective study

Riccardo Finotello, Maria Elisabetta Vasconi, Silvia Sabattini, Chiara Agnoli et autres

Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico-pathological and prognostic factors. One-hundred and 9 cats with newly diagnosed LGL lymphoma that underwent …

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CD9a expression in premalignant lesions, gastric and colorectal carcinoma

Sergejs Isajevs, Francesco Lozupone, Nataša Zarovni, Antonio Chiesi et autres

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