Ileana B. Quintero

The DoGA Consortium Atlas of Canine Enhancers and Promoters Across Tissues and Development

Carsten O. Daub, Işıl Takan, Matthias Hörtenhuber, Noora Salokorpi et autres

se, fi, ch, us (code pays fourni par la source)

The DoGA Consortium Atlas of Canine Enhancers and Promoters Across Tissues and Development

Işıl Takan, Matthias Hörtenhuber, Noora Salokorpi, Rijja Hussain Bokhari et autres

Abstract The domestic dog is a powerful genetic model for complex traits, disease and behaviours relevant to human biology, yet the canine genome still lacks a systematic transcription-defined atlas of regulatory elements. Existing resources have improved annotation but largely infer regulatory activity …

se, fi, us (code pays fourni par la source)

Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease

Karina Barreiro, Jenni Karttunen, Erkka Valo, Essi Viippola et autres

Abstract Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by …

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Small and Large Extracellular Vesicles From Human Preovulatory Follicular Fluid Display Distinct ncRNA Cargo Profiles and Differential Effects on KGN Granulosa Cells

Inge Varik, Katariina Johanna Saretok, Kristine Rosenberg, Ileana B. Quintero et autres

Follicular fluid extracellular vesicles (FF EVs) facilitate communication between oocytes and somatic cells within the ovarian follicle, playing a pivotal role in follicular development. This study highlights the molecular and functional distinctions between small (SEV) and large (LEV) FF EV subpopulations, revealing …

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Multi-omics Quality Assessment in Personalized Medicine Through European Infrastructure for Translational Medicine (EATRIS): An Overview

Patricia Alonso-Andrés, Davide Baldazzi, Qiaochu Chen, Elisa Conde et autres

Molecular characterization of a biological sample, e.g., with omics approaches, is fundamental for the development and implementation of personalized and precision medicine approaches. In this context, quality assessment is one of the most critical aspects. Accurate performance and interpretation of omics techniques …

Small and large extracellular vesicles from human preovulatory follicular fluid display distinct ncRNA cargo profile and differential effect on granulosa cell line KGN

Inge Varik, Katariina Johanna Saretok, Kristine Rosenberg, Ileana B. Quintero et autres

ABSTRACT Follicular fluid extracellular vesicles (FF EVs) facilitate communication between oocytes and somatic cells within the ovarian follicle, playing a pivotal role in follicular development. This study highlights the molecular and functional distinctions between small (SEV) and large (LEV) FF EV subpopulations, …

ee, fi, ua (code pays fourni par la source)

The DoGA consortium expression atlas of promoters and genes in 100 canine tissues

Matthias Hörtenhuber, Marjo K. Hytönen, Abdul Kadir Mukarram, Meharji Arumilli et autres

The dog, Canis lupus familiaris, is an important model for studying human diseases. Unlike many model organisms, the dog genome has a comparatively poor functional annotation, which hampers gene discovery for development, morphology, disease, and behavior. To fill this gap, we established …

se, fi, jp, us, gb (code pays fourni par la source)

Selected miRNAs in urinary extracellular vesicles show promise for non-invasive diagnostics of diabetic kidney disease

Karina Barreiro, Jenni Karttunen, Erkka Valo, Essi Viippola et autres

Abstract Diabetic kidney disease is a growing health burden that lacks specific early non-invasive diagnostic procedures. To approach a solution for this clinical need, we sequenced microRNAs of urinary extracellular vesicles and performed biomarker discovery by small RNA sequencing in a type …

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Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma

Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt et autres

Abstract Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to develop an EV‐based assay for the detection of RCC using a highly sensitive nanoparticle‐aided time‐resolved fluorescence …

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Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma

Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt et autres

Half of patients with renal cell carcinoma (RCC) will develop metastases. The disease is likely to be curable at early stages but incurable when metastatic. New and non-invasive biomarkers are needed for the diagnosis of RCC. Extracellular vesicles (EVs) are considered promising …

fi (code pays fourni par la source)

Multi-omics Quality Assessment in Personalized Medicine through EATRIS

Patricia Alonso-Andrés, Davide Baldazzi, Qiaochu Chen, Elisa Conde et autres

ABSTRACT Molecular characterization of a biological sample, e.g., with omics approaches, is fundamental for the development and implementation of personalized and precision medicine approaches. In this context, quality assessment is one of the most critical aspects. Accurate performance and interpretation of omics …

es, it, cn, fi, cz, se, nl, lu (code pays fourni par la source)

Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human

Julia E. Niskanen, Åsa Ohlsson, Ingrid Ljungvall, Michaela Drögemüller et autres

BACKGROUND: Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact …

fi, se, ch, nl, gb, si, ca, de (code pays fourni par la source)