Accès ouvert
2026
preprint
OpenAlex
Angel Gonzalez-Valero, Annika C. S. Page, Jayde M. Bertoch, Fadi Alsarhan et autres
Abstract Life is predicated on chirality, a molecular asymmetry akin to the left and right versions of human hands. Here we show that privileged protein residues are predisposed for chiral regulation. We developed enantiomeric oxaziridine reagents that systematically identify pro-( S ) …
us
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Accès ouvert
2025
article
OpenAlex
Annika C. S. Page, Lauren M. Orr, Margot L. Meyers, Bridget P. Belcher et autres
Deconvolution of the protein targets of hit compounds from phenotypic screens, often conducted in live cells, is critical for understanding mechanism of action and identifying potentially hazardous off-target interactions. While photoaffinity labeling and chemoproteomics are long-established approaches for discovering small-molecule-protein interactions in …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Annika C. S. Page, Lauren M. Orr, Margot L. Meyers, Bridget P. Belcher et autres
Deconvolution of the protein targets of hit compounds from phenotypic screens, often conducted in live cells, is critical for understanding mechanism of action and identifying potentially hazardous off-target interactions. While photoaffinity labeling and chemoproteomics are long-established approaches for discovering small-molecule-protein interactions in …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Angel Gonzalez-Valero, Audrey G. Reeves, Annika C. S. Page, Patrick J. Moon et autres
Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highly nucleophilic amino acids such as cysteine or lysine. Here, …
us, be
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Annika C. S. Page, Spencer O. Scholz, Jessica N. Spradlin, Bridget P. Belcher et autres
Pr acyl silanes were shown to selectively label recombinant BRD4-BD1 and FKBP12, respectively, with minimal background. Together, these data highlight the untapped potential of acyl silanes as a novel, tunable scaffold for photoaffinity labeling.
us
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Accès ouvert
2018
article
OpenAlex
Juntian Zhang, Annika C. S. Page, Vignesh Palani, Junhua Chen et autres
Thioamides bearing electron-withdrawing groups on the thiocarbonyl carbon atom react with benzynes [generated by the hexadehydro-Diels-Alder cycloisomerization] in an unprecedented fashion. Namely, the dihydrobenzothiazole products are consistent with a pathway involving initial formation of a stabilized ammonium ylide by a rare type …
us
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