Xueqin Gao

Interaction Mechanism of Bovine Myosin Oxidation Inhibition by Epicatechin Gallate: Insights from Molecular Docking and Thermodynamic Analysis

Xin Li, Meijuan Xu, Min Li, Xinming Yin et autres

Protein oxidation is a critical factor governing meat quality. Although lotus seedpod proanthocyanidins (LSPC) can inhibit protein oxidation in beef during refrigerated storage, the underlying mechanism remains unclear. This study investigated the antioxidant activity and conformation impacts of epigallocatechin gallate (ECG), the …

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Effects of Two Fisetin Dosing Regimens on Reducing Senescence-Related Genes in Peripheral Blood Mononuclear Cells in Aged Humans

Xueqin Gao, Joanna Roder, Lucas Minas, Jacob Singer et autres

Fisetin is a natural flavonoid that possesses antioxidant, anti-inflammatory, anti-senescence, and neuroprotective effects in preclinical studies. This double-blind randomized clinical trial investigated the effects of two fisetin dosing regimens on senescent gene expression in peripheral blood mononuclear cells (PBMCs) in elderly humans …

Preclinical Evaluation of Human Donor-Derived Micronized Bone Marrow Stroma/Parenchyma Versus Bone Marrow Aspirate Concentrate in a Rat Model of Post-Traumatic Knee Osteoarthritis

Haruki Nishimura, Zuokui Xiao, Jacob Singer, Xueqin Gao et autres

Bone marrow aspirate concentrate (BMAC) is widely used as a source of mesenchymal stromal/stem cells (MSCs) for musculoskeletal regeneration; however, BMAC lacks essential bone marrow extracellular matrix (ECM) components, a critical component of the stem cell niche that regulates MSC survival, paracrine …

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Network analysis identifies core fear symptoms as screening clues for post-PCI rehabilitation in patients with acute myocardial infarction

Yanrong Gu, Xiaomin Wu, Yiyi Chai, Ping Lin et autres

Background: Acute myocardial infarction is a leading cause of death among cardiovascular patients. Fear following percutaneous coronary intervention (PCI) can impede patient recovery. Thus, identifying the core and key symptoms of patients' fear and formulating corresponding countermeasures are essential. Objective: To analyze …

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Preparation, Binding Behavior and Molecular Simulation of Binary Complexes of Phloridzin with Whey Protein Isolate

J Q Li, Nanjun Liu, Furong Qin, Chenxi Qiu et autres

Whey protein isolate (WPI) can assemble into supramolecular complexes with flavonoids via non-covalent interactions, although the underlying binding mechanisms remain not fully understood. In this work, the formation mechanism of the WPI–phloridzin (PHL) complex was systematically investigated using an integrated experimental and …

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Magnesium-doped biomimetic intrafibrillar mineralized decellularized extracellular matrix cryogel with oriented microchannel for vascularized bone regeneration

Anbei Chen, Qianwen Yang, Xiaochen Ma, Xueqin Gao et autres

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Human BMP4 mRNA Encapsulated in Lipid Nanoparticle Delayed Cartilage Degeneration but Has a Limited Enhancement Effect on Bone Healing in Aged Mice

Xueqin Gao, Zuokui Xiao, Matthieu Huard, Keisuke Nakayama et autres

Segmental bone defects and age-related osteoarthritis (OA) are clinically challenging in terms of treatment. Although preclinical studies have demonstrated efficacy for bone defect healing and OA using ex vivo gene therapy or biomaterial sustain-release delivery, few have translated into clinical therapies due …

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SAFETY AND EFFICACY OF SENOLYTIC AND ANTI-FIBROTIC AGENTS TO IMPROVE THE BENEFIT OF BONE MARROW ASPIRATE CONCENTRATE INJECTION FOR OSTEOARTHRITIS

Scott Tashman, Grant Dornan, Joanna Roder, Sara Robinson et autres

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Protein Encoding Chemical Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair

Britney S Force, Xueqin Gao, Johnny Huard

Musculoskeletal disorders and injuries are highly prevalent and encompass a broad range of conditions, including bone fractures and segmental defects, tendinopathies and tendon injury, and cartilage disorders such as osteoarthritis, cartilage defects, and intervertebral disc disease. These conditions can arise from diverse …

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Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials

Xueqin Gao, Shuao Dong, Xiyue Zheng, 시윤희 et autres

Within the biomaterial-constructed bone repair microenvironment, intricate crosstalk among immune, osteogenic and vascular cells is essential for maintaining local osteoimmune homeostasis and driving tissue regeneration. Macrophages act as the central orchestrators within this osteoimmune microenvironment. As the first responders to injury, they …

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Bimetallic MOF‐Incorporated Hydrogel Scaffolds for Astaxanthin Delivery: Remodeling Bone Microenvironment and Accelerating Bone Repair

Yunhui Si, Jiaying Gu, Mengsha Li, Shuao Dong et autres

ABSTRACT Impaired bone regeneration in large defects is often caused by a hostile microenvironment featuring persistent inflammation, insufficient vascularization, and high oxidative stress, which collectively induce senescence and osteogenic impairment of bone marrow mesenchymal stem cells (BMSCs). Naturally derived astaxanthin is observed …

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Effect of exogenous salicylic acid spray on enhancing cold tolerance in ‘Northland’ blueberry plants under low-temperature stress

Xuedong Tang, Jianxin Li, Xueqin Gao, Binghan Liu et autres

Blueberry is a small berry with significant economic value; however, in the northern regions of China, low temperatures severely affect blueberry growth during early spring. Salicylic acid (SA), an important phytohormone, plays a crucial role in various physiological and metabolic responses induced …

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