Martin Samuels

P37 Transcutaneous vs end-tidal CO2 monitoring in tracheostomy-ventilation paediatric sleep studies

Ricky Damm, Leilani Mensah-Manuel, Matthew Davies, Vasileios Patelis et autres

Introduction Accurate CO2 monitoring during sleep studies is fundamental to optimising ventilation in children. While end-tidal CO2 (EtCO2) and Transcutaneous CO2 (TcCO2) are common alternatives to arterial blood gases (ABG), evidence regarding their agreement is mixed. TcCO2 has shown good agreement with …

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Survival in congenital central hypoventilation syndrome (CCHS): data from the European CCHS Consortium

Plamen Bokov, Panagiota Chaitidou-Kolb, Benjamin Dudoignon, Maria Giovanna Paglietti et autres

INTRODUCTION: Congenital central hypoventilation syndrome (CCHS) is a rare disorder characterised by autonomic dysfunction and impaired respiratory control. While advances in ventilatory support have improved survival, risk factors for mortality remain incompletely understood. Our objective was to investigate the impact of genetic …

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‘Funny turns’ in children: the long history of a paediatric conundrum

M A Anjay, Martin Samuels

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Antibiotic Neurotoxicity

Martin Samuels

Abstract This chapter presents an 88-year-old man with diffuse large B-cell lymphoma, Parkinson disease, and renal failure who develops four limbs shaking and encephalopathy following antibiotic exposure. His cerebrospinal fluid shows marked pleocytosis, low glucose, and high protein, while blood cultures grow …

Leptomeningitis and Ventriculitis in a Patient on Steroids

Martin Samuels

Abstract This chapter presents a 60-year-old man with hypersensitivity pneumonitis treated with corticosteroids who rapidly deteriorates from stupor to coma with fixed, dilated pupils. His cerebrospinal fluid shows profound hypoglycorrhachia and lymphocytic pleocytosis, while MRI reveals leptomeningitis and ventriculitis. Clinicians suspect an …

The Froin-Nonne Sign

Martin Samuels

Abstract This chapter presents a 44-year-old man with seizures and altered mental status, whose lumbar puncture reveals a dry tap followed by bloody, xanthochromic cerebrospinal fluid with markedly elevated protein, consistent with the Froin-Nonne sign. His medical history includes childhood medulloblastoma, radiation-induced …

Dental Numbness and the Quintothalamic Tract

Martin Samuels

Abstract This chapter presents the case of a 48-year-old man who develops dental numbness and left-hand sensory changes following cardiac catheterization for severe aortic stenosis. MRI reveals a small infarct in the right pontine tegmentum, explaining the left-sided sensory symptoms without accompanying …

Role of overnight oximetry in assessing the severity of obstructive sleep apnoea in children with Down syndrome

Hannah Vennard, Anna Selby, Menaga Ananthamoorthy, Elise Buchan et autres

Introduction: Cardiorespiratory polygraphy (CRP) is the predominant diagnostic technology for obstructive sleep apnoea (OSA) in tertiary centres in the UK. Nocturnal pulse oximetry (NPO) is cheaper and more accessible. Objective: This study evaluates the ability of NPO indices to predict OSA in …

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P51 Service evaluation: the modified hypoxic challenge test

Stephanie Brotherston, Paul Aurora, Aidan Laverty, Rogers Kirstie et autres

Introduction Following a feasibility study between 2019–2021, 1 we introduced a modified hypoxic challenge test (mHCT) to aid clinicians advising families and patients with complex needs, who used long term ventilation and planned air travel. We wanted to assess if the medical …

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Role of overnight oximetry in assessing the severity of obstructive sleep apnoea in children with Down syndrome: a dual-centre study

Hannah Vennard, Anna Selby, Menaga Ananthamoorthy, Elise Buchan et autres

BACKGROUND AND OBJECTIVE: Cardiorespiratory polygraphy (CRP) is the predominant technology used to diagnose obstructive sleep apnoea (OSA) in tertiary centres in the UK. Nocturnal pulse oximetry (NPO) is cheaper and more accessible. This study evaluates NPO indices' ability to predict OSA in …

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8295 A ‘curse’ no more: a history of congenital central hypoventilation syndrome ( CCHS)

Anjay Pillai, Martin Samuels

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Congenital Central Hypoventilation Syndrome (CCHS): Patient Quality of Life and Caregiver Burden

Casey M. Rand, Julien Pelissou, Narayanan Krishnamurthi, Xenia Proton de la Chapelle et autres

BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder characterized by autonomic dysregulation and abnormal control of breathing, necessitating lifelong artificial ventilation. The impact of CCHS on patient quality of life (QoL) and caregiver burden remains unquantified. METHODS: A cross-sectional …

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