Consolato Sergi

Life expectancy in clinical practice: assessment, communication, and decision-making

Consolato Sergi

ca (code pays fourni par la source)

Comorbidity Burden and Radiological Features Associated with Legionella pneumophila Pneumonia: A Retrospective Case–Control Study

Nicola Serra, Teresa Fasciana, Paola Di Carlo, Anna Giammanco et autres

Background: Legionella pneumophila is a leading cause of community- and hospital-acquired pneumonia (HAP/CAP), although the clinical and radiological features associated with infection remain incompletely defined. This study aimed to identify clinical, comorbidity-related, and chest computed tomography (CT) features associated with L. pneumophila …

it, ca (code pays fourni par la source)

Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies—A Scoping Review

Paola Di Carlo, Nicola Serra, Aducio Thiesen, Vito Rodolico et autres

Background: The biliary and pancreatic tract is increasingly recognized as a microbial ecosystem rather than a sterile environment. Dysbiosis contributes to inflammation, bile acid alterations, and carcinogenesis, with distinct microbiota profiles linked to progression from benign to malignant conditions. Clinical factors, including …

it, ca (code pays fourni par la source)

In vitro bioactivity, cytotoxicity, and gene silencing of graphene oxide as a Bcl-2 siRNA carrier in osteosarcoma cells with in vivo inflammatory response

Shanmuga Sundar Saravanabhavan, Zsolt Sarang, Nivetha Marimuthu, Sowri Victor Varun Raju et autres

Research on using graphene oxide (GO) as a potential carrier for small interfering RNA (siRNA) in the treatment of osteosarcoma is currently under intense investigation. Here, we focus on evaluating the GO as a carrier of bcl-2 siRNA in osteosarcoma cell lines …

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Small Round Cell Tumors of Soft Tissue and Skeleton in Children and Youth: A Narrative and TruSight-Based Illustrative Review of Diagnostic Cases

Anita Nagy, Consolato Sergi

Small round cell tumors (SRCT) affecting soft tissue and bone are a distinct category of malignancies. These lesions frequently exhibit similar clinical and radiologic features, may harbor overlapping histologic and immunophenotypic features, and generally have distinct prognostic outcomes. Therefore, in some instances, …

ca (code pays fourni par la source)

Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies

H. Helena Wu, Sarah Leng, David D. Eisenstat, Consolato Sergi et autres

The tumor suppressor p53, often referred to as the “guardian of the genome,” is mutated in more than half of human cancers. These mutations have a significant impact on cancer biology and response to therapy. p53 mutations involve a range of changes …

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Microbiome Dysbiosis, Chemoprophylaxis, and Tumor Microenvironment in Biliary–Pancreatic Tract Diseases: a scoping Review."

Paola Di Carlo, Nicola Serra, Consolato Sergi, Vito Rodolico et autres

Biliary tract cancers (BTCs) are aggressive malignancies with poor prognosis, and patients often harbor bile-pancreatic bacteria such as Escherichia coli and Pseudomonas spp., making effective antibiotic therapy crucial to prevent resistance and complications. Disruption of the microbiota may impair tumour response to …

Gallbladder Carcinoma

Consolato Sergi

In the past few years, researchers have concentrated on discovering the risk factors for developing gallbladder cancer (GBC). There is a high demand for identifying protocols to help with early diagnosis and modify some patients’ long-term progression. Unfortunately, GBC is a rare …

Interleukin-18: A Critical Culprit in Inflammatory Renal Disease

Consolato Sergi

ca (code pays fourni par la source)

bile microbiota

Paola Di Carlo, Consolato Sergi, Nicola Serra

Community-Acquired Legionella pneumophila Pneumonia: A Case-Control Study in Adult Inpatients from 2019 to 2024

Paola Di Carlo, Nicola Serra, Teresa Fasciana, Francesca Fasciana et autres

Background: Legionella pneumophila is frequently acquired in the community and generally linked to contaminated domestic hot water systems, hotels, or other environmental sources or of unknown origin. L. pneumophila is a leading cause of pneumonia, especially in high-risk patients such as those …

it, ca (code pays fourni par la source)

Blastic plasmacytoid dendritic cell neoplasm (BPDCN): international, multi-center collaboration and global registry program

Astghik Voskanyan, Maria Badikyan, Marina Konopleva, Alvaro J. Alencar et autres

BACKGROUND: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare and aggressive hematologic malignancy originating from plasmacytoid dendritic cell precursors. BPDCN shares common diagnostic and clinical features with other hematologic malignancies and various dermatological disorders. Differential diagnosis and treatment are challenging and …

am, us, ca, tw, tr, iq, it, cy, gb, Égypte, in, kw (code pays fourni par la source)