Aducio Thiesen

Biliary Tract and Pancreatic Cancer (BTPC) in Adult Patients: The Role of the Biliary Microbiota in Cancer and Therapeutic Strategies—A Scoping Review

Paola Di Carlo, Nicola Serra, Aducio Thiesen, Vito Rodolico et autres

Background: The biliary and pancreatic tract is increasingly recognized as a microbial ecosystem rather than a sterile environment. Dysbiosis contributes to inflammation, bile acid alterations, and carcinogenesis, with distinct microbiota profiles linked to progression from benign to malignant conditions. Clinical factors, including …

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Optimizing tissue acquisition to improve the diagnostic yield of endoscopic ultrasound-guided fine needle biopsy of solid masses: a quality improvement initiative

S Khan, Narges Ashrafinia, Pamela Mathura, Lakshmi Puttagunta et autres

Abstract Background A chart audit (pre-intervention, PRE) of endoscopic ultrasound (EUS)-fine needle biopsy (FNB) of solid masses identified a diagnostic yield of 75%. To improve diagnostic yield, a quality improvement intervention targeting tissue procurement and processing was developed and trialed (post-intervention, POST). …

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Endoplasmic Reticulum Associated Lipolysis Regulates Hepatic Fat Synthesis and Turnover

Jihong Lian, Russell Watts, Randal Nelson, John P. Kennelly et autres

Abstract Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is characterized and initiated by the excessive accumulation of triacylglycerols (TG) and cholesteryl esters (CE) in the liver. Hepatic TG and CE synthesis, lipolysis and transport are tightly regulated by nutritional status, and disruption of …

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Microbiome Dysbiosis, Chemoprophylaxis, and Tumor Microenvironment in Biliary–Pancreatic Tract Diseases: a scoping Review."

Paola Di Carlo, Nicola Serra, Consolato Sergi, Vito Rodolico et autres

Biliary tract cancers (BTCs) are aggressive malignancies with poor prognosis, and patients often harbor bile-pancreatic bacteria such as Escherichia coli and Pseudomonas spp., making effective antibiotic therapy crucial to prevent resistance and complications. Disruption of the microbiota may impair tumour response to …