Comorbidity Burden and Radiological Features Associated with Legionella pneumophila Pneumonia: A Retrospective Case–Control Study
Rattachement africain : it, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Legionella pneumophila is a leading cause of community- and hospital-acquired pneumonia (HAP/CAP), although the clinical and radiological features associated with infection remain incompletely defined. This study aimed to identify clinical, comorbidity-related, and chest computed tomography (CT) features associated with L. pneumophila pneumonia in hospitalized adults with community-acquired pneumonia (CAP). Methods: A retrospective case–control study was conducted at a tertiary-care university hospital in Italy between January 2019 and August 2025. Eighty patients positive for L. pneumophila were compared with 79 controls negative for L. pneumophila. Demographic, clinical, microbiological, and radiological data were collected, and factors independently associated with infection were evaluated using multivariable logistic regression analysis. Results: Patients with L. pneumophila infection exhibited a greater comorbidity burden, particularly heart failure, and were more frequently smokers. Bilateral lung involvement and hilar/mediastinal lymphadenopathy were significantly more common among Legionella-positive patients, whereas overall pulmonary complications and bilateral pleural effusion were more frequently observed in controls. Multivariable analysis identified comorbidity burden as an independent positive predictor of L. pneumophila infection, while intensive care unit admission, oxygen therapy, and pulmonary complication score were independently associated with a lower likelihood of infection. Conclusions: The integration of comorbidity assessment with readily available chest CT findings may help raise clinical suspicion of L. pneumophila pneumonia and support consideration of appropriate diagnostic testing.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comorbidity Burden and Radiological Features Associated with Legionella pneumophila Pneumonia: A Retrospective Case–Control Study
- Date Crossref
- 19/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Naples Federico II Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University of Palermo Department of Health Promotion pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo pays non établi dans la noticeÉtablissement de santé
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University of Alberta Department of Laboratory Medicine and Pathology pays non établi dans la noticeUniversité ou école supérieure
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AOU Policlinico “P. Giaccone” Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the Fight Against AIDS pays non établi dans la noticeÉtablissement de santé
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Spinal Unit at the P.O. “Villa delle Ginestre” of the ASP Palermo pays non établi dans la noticeInstitution
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Section of Emergency Radiology Unit of Policlinico University Hospital “Paolo Giaccone” pays non établi dans la noticeUniversité ou école supérieure
Federico II University Hospital, Department of Neuroscience — University of Naples Federico II et Department of Health Promotion — University of Palermo, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.