Mariana Remedios-Chan

Parenteral platforms for tunable, long-acting administration of a highly hydrophobic antiretroviral drug

Nima Akhavein, Marc M. Baum, Manjula Gunawardana, John A. Moss et autres

GSK2838232 (GSK8232) is a second-generation maturation inhibitor (MI) developed for the treatment of HIV with excellent broad-spectrum virological profiles. The compound has demonstrated promising clinical results as an orally administered agent. Additionally, the compound's physical and pharmacological properties present opportunities for exploitation …

es, gb, us (code pays fourni par la source)

Urine biomarkers individually and as a consensus model show high sensitivity and specificity for detecting UTIs

Marzieh Akhlaghpour, Emery Haley, Laura K. S. Parnell, Natalie Luke et autres

BACKGROUND: Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The significant rate of both SUC "negative" or "mixed flora/contamination" results …

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Urine Biomarkers Individually and as a Consensus Model Show High Sensitivity and Specificity for Detecting UTIs

Marzieh Akhlaghpour, Emery Haley, Laura K. S. Parnell, Natalie Luke et autres

We aimed to determine if infection-associated urine biomarkers can differentiate true urinary tract infection (UTI) from non-UTI controls. Midstream clean-catch urine samples were collected from asymptomatic volunteers and symptomatic subjects > 60 years old diagnosed with presumptive UTI in a specialty setting. …

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A Test Combining Multiplex-PCR with Pooled Antibiotic Susceptibility Testing Has High Correlation with Expanded Urine Culture for Detection of Live Bacteria in Urine Samples of Suspected UTI Patients

Richard A. Festa, Natalie Luke, Mohit Mathur, Laura K. S. Parnell et autres

ca, us (code pays fourni par la source)

Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis

Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Rob K. Fanter et autres

Abstract Purpose Long-acting formulations of the potent antiretroviral prodrug tenofovir alafenamide (TAF) hold potential as biomedical HIV prevention modalities. Here, we present a rigorous comparison of three animal models, C57BL/6 J mice, beagle dogs, and merino sheep for evaluating TAF implant pharmacokinetics …

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Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis

Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon George Webster et autres

Global efforts aimed at preventing human immunodeficiency virus type one (HIV-1) infection in vulnerable populations appear to be stalling, limiting our ability to control the epidemic. Long-acting, controlled drug administration from subdermal implants holds significant potential by reducing the compliance burden associated …

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Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis

Manjula Gunawardana, Mariana Remedios-Chan, Debbie Sanchez, Simon George Webster et autres

New HIV-1 infection rates far outpace the targets set by global health organizations, despite important progress in curbing the progression of the epidemic. Long-acting (LA) formulations delivering antiretroviral (ARV) agents for HIV-1 pre-exposure prophylaxis (PrEP) hold significant promise, potentially facilitating adherence due …

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Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model

Chunxia Zhao, Manjula Gunawardana, Francois J. Villinger, Marc M. Baum et autres

ABSTRACT The broadly neutralizing antibody (bNAb) VRC01, capable of neutralizing 91% of known human immunodeficiency virus type 1 (HIV-1) isolates in vitro , is a promising candidate microbicide for preventing sexual HIV infection when administered topically to the vagina; however, accessibility to …

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Pharmacokinetics of Long-Acting Tenofovir Alafenamide (GS-7340) Subdermal Implant for HIV Prophylaxis

Manjula Gunawardana, Mariana Remedios-Chan, Christine S. Miller, Rob K. Fanter et autres

Oral or topical daily administration of antiretroviral (ARV) drugs to HIV-1-negative individuals in vulnerable populations is a promising strategy for HIV-1 prevention. Adherence to the dosing regimen has emerged as a critical factor determining efficacy outcomes of clinical trials. Because adherence to …

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Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia

Itzel Evelyn Calleja-Macias, Kathryn Osann, Mariana Remedios-Chan, Hugo Alberto Barrera-Saldaña et autres

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