Mohit Mathur

Clinical Characteristics as Predictors of Healthcare Resource Utilization in Immunoglobulin A Nephropathy: A Retrospective Database Study

Nancy Cannizzaro, Hema K. Gandhi, Qiaoling Chen, Sasikiran Nunna et autres

Background: Progression rates in immunoglobulin A nephropathy (IgAN) are variable, making future healthcare needs in this patient population difficult to anticipate. Objectives: We sought to determine whether baseline patient characteristics at biopsy diagnosis are predictive of subsequent healthcare resource utilization (HCRU) in …

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IP48-14 FLIPPING A COIN: STATE-BY-STATE ANALYSIS REVEALS RESISTANCE GENE DETECTION CONCORDANCE WITH PHENOTYPIC ANTIBIOTIC SUSCEPTIBILITY IN URINARY TRACT INFECTION DIAGNOSTIC TESTING AVERAGES 50 PERCENT

John Van Savage, Emery Haley, Natalie Luke, William Lai et autres

Full Validation of Pooled Antibiotic Susceptibility Testing Using CLSI Methods and Performance Criteria in UTI Pathogens

Richard A. Festa, F. R. Cockerill, Rick L. Pesano, Emery Haley et autres

Background: Here, we validate a unique and rapid susceptibility assay, Pooled Antibiotic Susceptibility Testing (P-AST), used for complicated, persistent, and recurrent urinary tract infections (UTIs), following Clinical and Laboratory Standards Institute (CLSI) protocols and performance metrics. Methods: P-AST™ was validated against the …

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Association Between Surrogate Endpoints and Clinical Outcomes in Immunoglobulin A Nephropathy: A Systematic Literature Review

Maria Lorenzi, Sarah Ali, Sarah Cadarette, Stephen Ebohon et autres

INTRODUCTION: At least 50% of patients with immunoglobulin A nephropathy (IgAN) reach kidney failure within 12 years of diagnosis. Delayed progression to kidney failure remains the gold standard treatment endpoint in IgAN, but the prolonged time course limits feasibility as a primary …

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Burden of corticosteroid therapy in patients with immunoglobulin A nephropathy (IgAN): a systematic literature review

Sarah Ali, Nicole Fusco, Dilip Makhija, Vakaramoko Diaby et autres

BACKGROUND: Immunoglobulin A nephropathy (IgAN) is one of the most common forms of primary glomerulonephritis (GN) worldwide. While specific treatment differs regionally, treatment usually focuses on background therapy, with short-term (≤ 6 months) corticosteroids recommended as an add-on treatment for patients at …

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CKD progression, kidney failure, and mortality among US patients with IgA nephropathy

John J. Sim, Qiaoling Chen, Nancy Cannizzaro, Ancilla W. Fernandes et autres

BACKGROUND AND HYPOTHESIS: We assessed disease progression among patients with immunoglobulin A nephropathy (IgAN) and characterized factors associated with risk for adverse outcomes. METHODS: A retrospective longitudinal cohort (2000-2022) study of adults with biopsy-confirmed IgAN within Kaiser Permanente Southern California was performed. …

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Pooled Antibiotic Susceptibility Testing for Polymicrobial UTI Performs Within CLSI Validation Standards

Richard A. Festa, F. R. Cockerill, Rick L. Pesano, Emery Haley et autres

BACKGROUND/OBJECTIVES: Urinary tract infections (UTIs) pose an increasing risk of antimicrobial resistance, and novel diagnostic tests have been developed to address the limitations of standard urine culture in these cases. It is important that these novel tests be validated for agreement and …

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Pooled Antibiotic Susceptibility Testing Performs Within CLSI Standards for Validation When Measured Against Broth Microdilution and Disk Diffusion Antibiotic Susceptibility Testing of Cultured Isolates

Emery Haley, F. R. Cockerill, Rick L. Pesano, Richard A. Festa et autres

Background/Objectives: While new methods for measuring antimicrobial susceptibility have been associated with improved patient outcomes, they should also be validated using standard protocols for error rates and other test metrics. The objective of this study was to validate a novel susceptibility assay …

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Comparing Prescribing Behaviors and Clinician Experiences Between Multiplex PCR/Pooled Antibiotic Susceptibility Testing and Standard Urine Culture in Complicated UTI Cases

Emery Haley, Natalie Luke, Howard Korman, David Baunoch et autres

Background/Objectives: We aimed to compare the prescribing behavior and clinical experience of urology providers when using the combined multiplex polymerase chain reaction (M-PCR)/Pooled Antibiotic Susceptibility Testing (P-AST) diagnostic test versus the standard urine culture (SUC) in the same set of patients previously …

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Incidence of Adult Primary Immunoglobulin A Nephropathy among a Racially/Ethnically Diverse Population in the United States

John J. Sim, Qiaoling Chen, Nancy Cannizzaro, Simran K. Bhandari et autres

INTRODUCTION: IgA nephropathy (IgAN), a leading cause of kidney failure worldwide, is one of the most common forms of primary glomerulonephropathy with variability by race and ethnicity. Using a diverse cohort within a large integrated health system in the United States (US), …

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Noninferiority of Multiplex Polymerase Chain Reaction Compared to Standard Urine Culture for Urinary Tract Infection Diagnosis in Pediatric Patients at Hackensack Meridian Health Children’s Hospital Emergency Department

Sejal M. Bhavsar, Nisha Polavarapu, Emery Haley, Natalie Luke et autres

Objective: To establish the noninferiority of the rapid and sensitive multiplex polymerase chain reaction (M-PCR) method versus standard urine culture (SUC) in pediatric urinary tract infection (UTI) diagnostic testing. Methods: A United States of America (USA)-based single-center prospective observational study of 44 …

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The Anti-APRIL Antibody Sibeprenlimab Reduces Circulating Immune Complexes in Patients with IgAN: The Phase 2 ENVISION Randomized Controlled Trial

Jonathan Barratt, Mohit Mathur, Adrian Liew, Muh Geot Wong et autres

Background: Deposition of IgA-containing circulating immune complexes (CICs) in the kidney is a hallmark of IgA nephropathy (IgAN); A PRoliferation-Inducing Ligand (APRIL) is a driver in this pathogenesis. Sibeprenlimab, an APRIL-neutralizing, humanized IgG2 monoclonal antibody, demonstrated acceptable safety with robust reductions in …

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