Nina Chevalier

Einfluss chronischer Entzündung auf Eigenschaften, Seneszenz und immunmodulatorische Funktion mesenchymaler Stromazellen in einem Lupus-Mausmodell

Nina Chevalier, Sophia Berenike Schreiber, Paola Fernanda Ruiz Aparicio, Anna-Lena Schaefer et autres

Einleitung: Mesenchymale Stromazellen (MSCs) sind zentrale Akteure der regenerativen Medizin, da sie Hämatopoese, Gewebereparatur und Immunmodulation fördern und gezielt in entzündete Gewebe migrieren. Beim systemischen Lupus erythematodes (SLE) verbessern sie in Modellen und bei Patient:innen [zum vollständigen Text gelangen Sie über die …

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Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Victoria Cousin, Anna Graumann, Valerie Geiger, David Sökler et autres

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have repeatedly been reported in CVIDc, …

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USP8 controls proteostasis pathways in B cells and multiple myeloma

Almut Dufner, Fabien Thery, Gianni Monaco, Jelena Lazarevic et autres

Abstract Ubiquitin-specific protease 8 (USP8) plays a pivotal role in the regulation of endosomal and lysosomal trafficking and is critically involved in the pathogenesis of various tumor entities. USP8 represents a vulnerability gene in multiple myeloma (MM), suggesting a functional role in …

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Interleukin-10 at the crossroads of immunity in TLR7-induced lupus

Johanna Pauline Williams, Anaïs Amend, Anna-Lena Schäfer, Paola Fernanda Ruiz-Aparicio et autres

Objective Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by dysregulated innate and adaptive immunity. Soluble mediators like cytokines critically shape immune responses and sustain chronic inflammation. Interleukin-10 (IL-10), typically anti-inflammatory, also exerts pro-inflammatory effects in SLE, for example by …

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C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway

Julia Thomé, Julia Limmer, Teresa Z. Brose, Johannes Zeller et autres

Introduction: T cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection. Monomeric CRP (mCRP) is a known modulator of inflammation and particularly the innate …

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Circulating Tumor Cell-Based Molecular Biomarkers of 177Lu-PSMA-617 Treatment Efficacy in Metastatic Prostate Cancer

Yasumasa Miyazawa, Arda Könik, K. Otani, Rea Pittie et autres

C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets

Jurij Kiefer, Johannes Zeller, Laura Schneider, Julia Thomé et autres

INTRODUCTION: Despite advancements in transplant immunology and vascularized composite allotransplantation (VCA), the longevity of allografts remains hindered by the challenge of allograft rejection. The acute-phase response, an immune-inflammatory reaction to ischemia/reperfusion that occurs directly after allogeneic transplantation, serves as a catalyst for …

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USP8 Controls Proteostasis Pathways in B Cells and Multiple Myeloma

Almut Dufner, Fabien Théry, Gianni Monaco, Jelena Lazarević et autres

Abstract Ubiquitin-specific protease 8 (USP8) is a multifunctional deubiquitinating enzyme that plays a pivotal role in the regulation of endosomal and lysosomal trafficking. Several studies showed that USP8 is critically involved in the pathogenesis of various tumor entities. Recently, USP8 emerged as …

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Burden of disease and impact on quality of life in chronic back pain – a comparative cross-sectional study of 150 axial spondyloarthritis and 150 orthopedic back pain patients

Natalie Frede, Sonja Hiestand, Dominique Endres, Ludger Tebartz van Elst et autres

Objective Chronic back pain (CBP) constitutes one of the most common complaints in primary care and a leading cause of disability worldwide. CBP may be of mechanical or inflammatory character and may lead to functional impairment and reduced quality of life. In …

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Crosstalk in the diseased plasma cell niche – the force of inflammation

Anna-Lena Schäfer, Paola Fernanda Ruiz-Aparicio, Antoine N. Kraemer, Nina Chevalier

OPINION article Front. Immunol., 21 February 2023Sec. B Cell Biology Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1120398

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Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice

Antoine N. Kraemer, Anna-Lena Schäfer, Dalina T. L. Sprenger, Bettina Sehnert et autres

Vitamin D (VD) deficiency is a highly prevalent worldwide phenomenon and is extensively discussed as a risk factor for the development of systemic lupus erythematosus (SLE) and other immune-mediated diseases. In addition, it is now appreciated that VD possesses multiple immunomodulatory effects. …

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Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms

Bettina Sehnert, Sandy Pohle, Cornelia Heuberger, Maximilian Seidl et autres

A link between high sodium chloride (salt) intake and the development of autoimmune diseases was previously reported. These earlier studies demonstrated exacerbation of experimental autoimmune encephalomyelitis and colitis by excess salt intake associated with Th17- and macrophage-mediated mechanisms. Little is known about …

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