Cornelia Heuberger

Immune microniches shape intestinal Treg function

Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alice Bertocchi et autres

Abstract The intestinal immune system is highly adapted to maintaining tolerance to the commensal microbiota and self-antigens while defending against invading pathogens 1,2 . Recognizing how the diverse network of local cells establish homeostasis and maintains it in the complex immune environment …

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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses

Cornelia Heuberger, Alina Janney, Nicholas Edward Ilott, Alice Bertocchi et autres

Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory CD4 + T cell responses. Using selective gene ablation of MHC II …

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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

Cornelia Heuberger, Alina Janney, Nicholas Edward Ilott, Alice Bertocchi et autres

Abstract Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory CD4 + T cell responses. Using selective gene ablation of MHC …

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Intestinal lamina propria supports acquired eTreg suppressor function

Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alina Janney et autres

Abstract The intestinal immune system must maintain tolerance to commensal microbiota and self antigens whilst defending against invading pathogens. Recognising how homeostasis is established and maintained in a complex immune environment such as the gut is critical to understanding how to re-establish …

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Low-Salt Diet Attenuates B-Cell- and Myeloid-Cell-Driven Experimental Arthritides by Affecting Innate as Well as Adaptive Immune Mechanisms

Bettina Sehnert, Sandy Pohle, Cornelia Heuberger, Maximilian Seidl et autres

A link between high sodium chloride (salt) intake and the development of autoimmune diseases was previously reported. These earlier studies demonstrated exacerbation of experimental autoimmune encephalomyelitis and colitis by excess salt intake associated with Th17- and macrophage-mediated mechanisms. Little is known about …

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The role and uses of antibodies in COVID-19 infections: a living review

David Oliver Scourfield, Sophie G. Reed, Max N. Quastel, Jennifer Alderson et autres

Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to …

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Mucosal immune responses in COVID19 - a living review

Claire F. Pearson, Rebecca Jeffery, David Ahern, Hannah Almuttaqi et autres

COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many organs and cause a broad pathological response. The primary infection site is likely to be a …

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Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology

Amy Susan Codd, Stephanie Jean Hanna, Ewoud Bernardus Compeer, Felix Clemens Richter et autres

Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which manifests in …

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Antigen presentation and T cell regulation by intestinal epithelial cells

Cornelia Heuberger

Major histocompatibility complex (MHC) class II expression by intestinal epithelial cells (IECs) has been described in inflammatory bowel disease patients. However, the role of epithelial antigen presentation in the maintenance of immune homeostasis remains unclear. We determined that colonic IECs possess important …

T cell phenotypes in COVID-19 - a living review

Stephanie Jean Hanna, Amy Susan Codd, Ester Gea‐Mallorquí, David Oliver Scourfield et autres

COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of activation and exhaustion. However, antigen-specific T cell responses are emerging as a crucial mechanism for both clearance of the …

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Why do intestinal epithelial cells express MHC class II?

Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy

Intestinal epithelial cells (IECs) constitute the border between the vast antigen load present in the intestinal lumen and the mucosal immune compartment. Their ability to express antigen processing and presentation machinery evokes the question whether IECs function as non-conventional antigen-presenting cells. Major …

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