Saketh Sriram Dinavahi

In silico and in vitro analysis of the genotoxic and mutagenic potential of STING modulators

Santosh Vishwakarma, Saketh Sriram Dinavahi, Kapil R Nikam, Bibhuti Ranjan et autres

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Emerging Role of the p53 Pathway in Modulating NK Cell–Mediated Immunity

Yu‐Chi Chen, Christopher G. Bazewicz, Saketh Sriram Dinavahi, Nicholas D. Huntington et autres

The p53 pathway plays an important role in role in cancer immunity. Mutation or downregulation of the proteins in the p53 pathway are prevalent in many cancers, contributing to tumor progression and immune dysregulation. Recent findings suggest that the activity of p53 …

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Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations

Venugopal Vangala, Yu‐Chi Chen, Saketh Sriram Dinavahi, Krishne Gowda et autres

The goal of this project was to demonstrate that subpopulations of cells in tumors can uniquely fluctuate in size in response to environmental conditions created during drug treatment, thereby acting as a dynamic “rheostat” to create a favorable tumor environment for growth. …

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Data from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Saketh Sriram Dinavahi, Yu‐Chi Chen, Kishore Punnath, Arthur S Berg et autres

Abstract Immunotherapy has revolutionized cancer treatment. Unfortunately, most tumor types do not respond to immunotherapy due to a lack of immune infiltration or “cold” tumor microenvironment (TME), a contributing factor in treatment failure. Activation of the p53 pathway can increase apoptosis of …

Supplementary Figure from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Saketh Sriram Dinavahi, Yu‐Chi Chen, Kishore Punnath, Arthur S Berg et autres

Supplementary Figure from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Data from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Saketh Sriram Dinavahi, Yu‐Chi Chen, Kishore Punnath, Arthur S Berg et autres

Abstract Immunotherapy has revolutionized cancer treatment. Unfortunately, most tumor types do not respond to immunotherapy due to a lack of immune infiltration or “cold” tumor microenvironment (TME), a contributing factor in treatment failure. Activation of the p53 pathway can increase apoptosis of …

Supplementary Figure from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Saketh Sriram Dinavahi, Yu‐Chi Chen, Kishore Punnath, Arthur S Berg et autres

Supplementary Figure from Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma

Saketh Sriram Dinavahi, Yu‐Chi Chen, Kishore Punnath, Arthur S Berg et autres

Immunotherapy has revolutionized cancer treatment. Unfortunately, most tumor types do not respond to immunotherapy due to a lack of immune infiltration or "cold" tumor microenvironment (TME), a contributing factor in treatment failure. Activation of the p53 pathway can increase apoptosis of cancer …

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Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development

Saketh Sriram Dinavahi, Yu‐Chi Chen, Raghavendra Gowda, Pavan Kumar Dhanyamraju et autres

Decreasing the levels of certain proteins has been shown to be important for controlling cancer but it is currently unknown whether proteins could potentially be targeted by the inhibiting of protein synthesis. Under this circumstance, targeting protein translation could preferentially affect certain …

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Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Yu‐Chi Chen, Saketh Sriram Dinavahi, Qilong Feng, Raghavendra Gowda et autres

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Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery

Gregory R. Kardos, Raghavendra Gowda, Saketh Sriram Dinavahi, Scot R. Kimball et autres

Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels …

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The role of exosomes in metastasis and progression of melanoma

Raghavendra Gowda, Bailey M. Robertson, Soumya Iyer, John Mitchell Barry et autres

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