Venugopal Vangala

Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth

Ray Zhang, Longgui Chen, Xinwen Liang, Jiawen Zhang et autres

The AAA+ ATPase VPS4 drives the ESCRT machinery in diverse intracellular membrane remodeling events, including endocytic receptor sorting, membrane repair, and autophagosome closure. Tumor cells often lose one VPS4 paralog (VPS4A or VPS4B), making them dependent on the remaining enzyme and creating …

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Cell-engineered technologies for wound healing and tissue regeneration

Malay Nayak, Durba Banerjee, Venugopal Vangala, Susheel Kumar Nethi et autres

This review provides a comprehensive analysis of diverse cell-engineered technologies for wound healing and tissue regeneration, highlighting various engineered techniques in a single article. It discusses different types of genetic modifications in various cell types to enhance cellular therapeutic properties. It also …

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Targeted Liposome Garcinol Formulation for the Treatment of Colon Cancer: Pharmacological and Toxicological Evaluation

Kalpana Javvaji, Venugopal Vangala, Shruti Deshpande, Sujitha Matta et autres

Garcinol is a secondary metabolite commonly found in Garcinia plant species that exhibits potential anticancer properties but faces challenges in delivery due to its insolubility in aqueous solutions, rapid elimination from the body, and poor bioavailability. To overcome these limitations, a targeted …

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Melanoma immunotherapy by nanosphere-vaccine elicited CD4+ and CD8+ T-cell response for tumor regression

Kalpana Javvaji, Venugopal Vangala, Suresh Babu Sayana, Bhanu Maturi et autres

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DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice

Kevin A. Fundora, Zhuang Yan, Kouta Hamamoto, Guifang Wang et autres

Vacuolar protein sorting 4 (VPS4) is an AAA-ATPase that catalyzes the endosomal sorting complex required for transport-III disassembly, mediating various cellular membrane-remodeling processes including endolysosomal membrane repair and autophagosome closure. Humans have 2 VPS4 paralogs, VPS4A and VPS4B, and the loss of …

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Advancement of Nanomaterials- and Biomaterials-Based Technologies for Wound Healing and Tissue Regenerative Applications

Durba Banerjee, Kalyan Vydiam, Venugopal Vangala, Sudip Mukherjee

Patients and healthcare systems face significant social and financial challenges due to the increasing number of individuals with chronic external and internal wounds that fail to heal. The complexity of the healing process remains a serious health concern, despite the effectiveness of …

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Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations

Venugopal Vangala, Yu‐Chi Chen, Saketh S. Dinavahi, Krishne Gowda et autres

The goal of this project was to demonstrate that subpopulations of cells in tumors can uniquely fluctuate in size in response to environmental conditions created during drug treatment, thereby acting as a dynamic “rheostat” to create a favorable tumor environment for growth. …

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Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor

Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Lone et autres

Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to several drugs. Several ALDH inhibitors have …

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One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma In Vivo

Yarra Venkatesh, Venugopal Vangala, Rakesh Mengji, Amrita Chaudhuri et autres

Herein, we report three new metal-free, photochemically active single, dual, and combinatorial CORMs (photoCORMs) based on a carbazole-fused 1,3-dioxol-2-one moiety which released one equivalent of CO, two equivalent of CO, and a combination of one equivalent of each CO and anticancer drug …

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A facile one-pot, three component synthesis of a new series of 1,3,4-thiadiazines: Anticancer evaluation and molecular docking studies

Srikanth Mamidala, Venugopal Vangala, Saikiran Reddy Peddi, Raju Chedupaka et autres

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Combating Glioblastoma by Codelivering the Small-Molecule Inhibitor of STAT3 and STAT3siRNA with α5β1 Integrin Receptor-Selective Liposomes

Venugopal Vangala, Narendra Varma Nimmu, Sara Khalid, Madhusudana Kuncha et autres

Glioblastoma multiforme (GBM) is one of the most aggressive tumors with a median survival of only 15 months. Effective therapeutics need to overcome the formidable challenge of crossing the blood-brain barrier (BBB). Receptors and transporters overexpressed on BCECs are being used for …

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A lysosome-specific near-infrared fluorescent probe for in vitro cancer cell detection and non-invasive in vivo imaging

Rakesh Mengji, Chiranjit Acharya, Venugopal Vangala, Avijit Jana

Near-infrared (NIR) fluorescent probes have been developed as potential bio-materials having profound applications in diagnosis and clinical practice. Herein, we wish to disclose a highly photostable ultra-bright NIR probe for the specific detection of lysosomes in numerous cell lines. Furthermore, the applicability …

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