Accès ouvert
2026
article
OpenAlex
Vlad Ionescu, Gina Gheorghe, Roxana‐Manuela Vasile, Claudia‐Lucia Ionescu et autres
Encephalopathy is a heterogeneous clinical syndrome with numerous neurological and systemic etiologies. We report the case of a 67-year-old man, a chronic ethanol consumer, admitted with a one-week history of confusional syndrome. Initial laboratory tests revealed severe hypercalcemia, acute kidney injury, mild …
ro
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Accès ouvert
2026
article
OpenAlex
Ninel Iacobus Antonie, Vlad Ionescu, Gina Gheorghe, Loredana-Crista Tiucă et autres
Background/Objectives: Antimicrobial resistance (AMR) remains a major global health threat, strengthening the case for antimicrobial stewardship strategies that limit unnecessary broad-spectrum empiric therapy while preserving timely escalation when clinically warranted. Before any clinical deployment of large language model (LLM)-based antibiotic decision support …
ro
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Accès ouvert
2026
preprint
OpenAlex
Ninel Iacobus Antonie, Vlad Ionescu, Gina Gheorghe, Crista-Loredana TIUCA et autres
Background/Objectives: Antimicrobial resistance (AMR) remains a major global health threat, strengthening the case for antimicrobial stewardship that limits unnecessary broad-spectrum empiric therapy while preserving timely coverage in severe infection. Large language models (LLMs) are being explored for decision support, but require rigorous …
ro
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Accès ouvert
2026
article
OpenAlex
Mihai Stana, Teodor Florin Georgescu, Dragos Eugen Georgescu, Maria Francisca Georgescu et autres
RezumatContext: Managementul cancerului de sân a cunoscut o evoluţie importantă, trecând de la intervenţii chirurgicale agresive şi invazive către strategii personalizate, multidisciplinare, ghidate de biologia tumorală şi de rezultate orientate către pacient.Progrese recente: Studiile clinice randomizate au permis deescaladarea tratamentului chirurgical în …
ro, us
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Accès ouvert
2025
article
OpenAlex
Vlad Ionescu, Alice Elena Ciontu, Gabriel Ianu Ianuș, Vlad Buică et autres
Celiac disease (CeD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals, with a heterogeneous clinical spectrum spanning classical gastrointestinal symptoms, extraintestinal manifestations, and subclinical forms. We synthesize contemporary epidemiology, immunopathogenesis, and the updated 2025 European Society for the Study …
ro
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Accès ouvert
2025
review
OpenAlex
Loredana-Crista Tiucă, Gina Gheorghe, Vlad Ionescu, Ninel Iacobus Antonie et autres
Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a systemic condition in which muscle wasting, malnutrition, and altered fluid balance strongly influence prognosis. While spirometry remains essential for diagnosis and staging, it often fails to reflect the heterogeneity of outcomes. Multifrequency …
ro
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Accès ouvert
2025
article
OpenAlex
Vlad Buică, Ancuța Năstac, Gina Gheorghe, Teodor Florin Georgescu et autres
Background: Colorectal cancer (CRC) represents one of the leading causes of cancer-related morbidity and mortality globally. Although national screening programs in Europe and the United States have demonstrated success in reducing incidence and death rates among populations aged 50 and above, a …
ro
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Accès ouvert
2025
article
OpenAlex
Vlad Ionescu, Gina Gheorghe, Coralia Bleoţu, Liliana Puiu et autres
Background/Objectives: MiRNAs have demonstrated promising roles in the diagnosis of pancreatic cancer and in the prognostic assessment of affected patients. Methods: We conducted a prospective pilot study including 23 patients diagnosed with advanced-stage pancreatic cancer and 10 healthy controls, matched by age …
ro, us
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Accès ouvert
2025
article
OpenAlex
Vlad Ionescu, Gina Gheorghe, Ioana-Alexandra Baban, Ninel Iacobus Antonie et autres
Background/Objectives: Mismatch repair (MMR) deficiency assessment has proven to be a valuable tool for prognostic evaluation and therapeutic management guidance in patients with colorectal cancer (CRC). Our study aimed to investigate the associations between MMR deficiency and a range of clinicopathological parameters. …
ro, us
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Accès ouvert
2025
article
OpenAlex
Ana Iulia Neagu, Marinela Bostan, Vlad Ionescu, Gina Gheorghe et autres
Colorectal cancer (CRC) is a multifactorial disease increasingly recognized for its complex interplay with the gut microbiota. The disruption of microbial homeostasis—dysbiosis—has profound implications for intestinal barrier integrity and host immune function. Pathogenic bacterial species such as Fusobacterium nucleatum, Escherichia coli harboring …
ro, sk
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Accès ouvert
2025
conference-paper
OpenAlex
Vlad Ionescu, Utz Roedig
Existing optimizations such as Early Data Transmission (EDT) and Improved Early Data Transmission (EDT+) improve Narrowband Internet of Things (NB-IoT) energy efficiency significantly. These improvements support battery-free or energy-harvesting NB-IoT devices and offer a promising path toward more energy-efficient deployments. In this …
ie
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Accès ouvert
2025
article
OpenAlex
Vlad Ionescu, Camelia Cristina Diaconu, Gina Gheorghe, Marinela Bostan et autres
The gut microbiome, a complex community of microorganisms residing in the intestinal tract, plays a dual role in colorectal cancer (CRC) development, acting both as a contributing risk factor and as a protective element. This review explores the mechanisms by which gut …
ro
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