Giuseppe Azzarello

From Bulk to Spatially Resolved Single-Cell Omics: Shaping Future Prognostic and Predictive Stratification in Head and Neck Squamous Cell Carcinoma

Simonetta Ausoni, Alessandra Casarin, Giuseppe Azzarello

Head and neck squamous cell carcinoma (HNSCC) is characterized by marked intratumoral heterogeneity and complex tumor-immune-stromal interactions, which shape therapeutic response and clinical outcome. Despite extensive transcriptomic efforts, bulk RNA sequencing has faced significant limitations, often failing to generate robust prognostic or …

it (code pays fourni par la source)

Chemoimmunotherapy Combinations in Elderly Patients with Metastatic Non-Small Cell Lung Cancer and PD-L1 Expression < 50%: Results from an Italian Real-World Study

Antonello Veccia, Ettore D’Argento, Floriana Morgillo, Elio Gregory Pizzutilo et autres

Background: Chemoimmunotherapy combinations represent the standard first-line treatment for non-oncogene addicted metastatic NSCLC (mNSCLC). However, evidence in elderly patients remains limited and conflicting. We conducted an analysis of the efficacy and safety of chemoimmunotherapy in patients aged ≥75 years enrolled in the …

it (code pays fourni par la source)

Symmetric Theory Omnipresent Medium Planck

Giuseppe Azzarello

In this article, we continue the development of the Symmetric Theory.What we will show is the coupling between the universe and the medium Planck, understood as the medium that formalises the characteristics of the zero-point field.We will show how the phenomena of …

it (code pays fourni par la source)

Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project

Stefania Gori, Fiorenza De Rose, Antonella Ferro, Alessandra Fabi et autres

Breast cancer stands as the most frequently diagnosed cancer and the primary cause of cancer-related mortality among women worldwide, including Italy. With the increasing number of survivors, many are enrolled in regular follow-up programs. However, adherence to recommendations from scientific societies (such …

it, us (code pays fourni par la source)

Tumor Budding, p53, and DNA Mismatch Repair Markers in Sinonasal Intestinal-Type Adenocarcinoma: A Retrospective Study Supports the Adverse Prognostic Impact of Tumor Budding

Sebastiano Puccio, Giuseppe Azzarello, Valeria Maffeis, Licia Laurino et autres

Sinonasal intestinal-type adenocarcinoma (ITAC) is a very rare, closely occupational-related tumor with strong histological similarities to colorectal cancer (CRC). In the latter, tumor budding (TB) is widely recognized as a negative prognostic parameter. The aim of this study was to evaluate the …

it (code pays fourni par la source)

Electrochemotherapy as adjuvant treatment in a sinonasal mucosal melanoma in elderly patient: a case report

Silvia Carpenè, Barbara Silvestri, Martina Bertinazzi, Enrico Armato et autres

it (code pays fourni par la source)

Follow-up of breast cancer: why is it necessary to start a Consensus in 2024?

Stefania Gori, Alberto Zambelli, Catia Angiolini, Antonella Ferro et autres

In Italy, breast cancer is the most frequently diagnosed cancer in women, with 55,900 new cases in 2023 (over 90% in the early stages). Due to the screening, early diagnosis and adjuvant treatment, these patients have a 5-years survival rate of 87% …

it (code pays fourni par la source)

European e-Delphi process to define expert consensus on electrochemotherapy treatment indications, procedural aspects, and quality indicators in melanoma

Luca Giovanni Campana, Sofia Farronato, Jackie Hodgetts, Joy Odili et autres

BACKGROUND: Skin metastases are an important co-morbidity in melanoma. Despite broad adoption, electrochemotherapy implementation is hindered by a lack of treatment indications, uncertainty regarding procedural aspects, and the absence of quality indicators. An expert consensus may harmonize the approach among centres and …

gb, it, de, pt, ch, si, es, pl, hu (code pays fourni par la source)

Cardiac wasting in head and neck cancer and in cardiac autopsies from different cancer types: A study in a chemo‐naïve setting

Sara Calamelli, Samantha Noto, Alessandra Baldoni, Alessandra Casarin et autres

BACKGROUND: Cardiac wasting is a detrimental consequence of cancer that has been traditionally ignored and often misinterpreted as an iatrogenic effect. METHODS: We conducted a retrospective study on 42 chemo-naive patients affected by locally advanced head and neck cancer (HNC). Based on …

it (code pays fourni par la source)

Prognostic value of baseline G8 geriatric assessment in a real-life population of elderly metastatic colorectal cancer patients: The Gold Study.

Giulia Maddalena, Alessandra Anna Prete, Federica Buggin, Fable Zustovich et autres

e24015 Background: Colorectal cancer (CRC) is the second most frequent malignancy in patients (pts) aged 70. Elderly patients are often excluded by clinical trials; however, improvements in quality of life and comorbidities management led to expand the access to anticancer treatments irrespectively …

it (code pays fourni par la source)

Clinical profile and mortality of Sars-Cov-2 infection in cancer patients across two pandemic time periods (Feb 2020–Sep 2020; Sep 2020–May 2021) in the Veneto Oncology Network: The ROVID study

Maria Vittoria Dieci, Giuseppe Azzarello, Vittorina Zagonel, Franco Bassan et autres

INTRODUCTION: We analyzed a cohort of patients with cancer and Sars-Cov-2 infection from the Veneto Oncology Network registry across two pandemic time periods. MATERIALS AND METHODS: 761 patients with cancer and SARS-CoV-2 infection were included. RESULTS: 198 patients were diagnosed during the …

it (code pays fourni par la source)

Nasopharyngeal cancer in non-endemic areas: Impact of treatment intensity within a large retrospective multicentre cohort

Paolo Bossi, Annalisa Trama, Alice Bernasconi, Salvatore Grisanti et autres

it, ca, jo, es, tr, us, kw, de, ru (code pays fourni par la source)