2022 conference-abstract

Prognostic value of baseline G8 geriatric assessment in a real-life population of elderly metastatic colorectal cancer patients: The Gold Study.

Giulia Maddalena, Alessandra Anna Prete, Federica Buggin, Fable Zustovich, Jessica Cadau, Giuseppe Azzarello, Letizia Procaccio, Caterina Soldà, Mario Domenico Rizzato, Cosimo Rasola, Claudia Galante, Eleonora Bergo, Silvia Montelatici, Ciro Longobardi, Giorgia Boscolo, Filomena Graziani, Luca Boni, Sara Lonardi, Vittorina Zagonel, Francesca Bergamo

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5Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : it. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

e24015 Background: Colorectal cancer (CRC) is the second most frequent malignancy in patients (pts) aged 70. Elderly patients are often excluded by clinical trials; however, improvements in quality of life and comorbidities management led to expand the access to anticancer treatments irrespectively of age per se. Finding new tools to stratify vulnerability in elderly pts is crucial to guide clinicians in therapeutic decisions. G8 and timed up and go test (TUG) have been related to prognosis and functional decline in patients affected by several solid tumors. However, no studies focused on TUG and G8 prognostic value in CRC pts are available. In this study, we assessed the prognostic value of G8 and TUG in a cohort of real-life elderly pts with metastatic CRC (mCRC). Methods: GOLD was a multicentre, observational, prospective study in which pts aged 70 with mCRC and eligible to 1st line therapy were enrolled. G8 and TUG were performed at screening and at the first documented disease progression (PD). G8 cutoff was 14, as reported in literature; TUG8,5 sec (cutoff set with ROC curve using MedCalc software v 20.027). PFS and OS were described with Kaplan-Meyer curve. All analyzed variables were then compared with multivariate models. Primary endpoint of the study was to assess prognostic value of G8 in OS and PFS. Secondary endpoints were to assess prognostic value of TUG in OS and PFS. Results: Since Oct 2017 to Apr 2019, 109 pts were evaluated in 4 different Oncology Units in Veneto (IT); 4 were not eligible to anticancer treatments and where thus excluded. 105 pts were finally enrolled. Clinical, histological and molecular characteristics were well balanced between pts with G814 vs > 14, with the exception of RASmut, more represented in the G8 > 14 group (p = 0,0195). 39 (37%) pts were aged80; 46 (44%) had ECOG PS1; 55 (53%) had RASmut; 15 (15%) had BRAFmut. 81 (77%) had G814; 78 (75%) had TUG8,5. At a median follow up time of 41,2 months, median OS was 19,41 months (95%CI 15,46-23,19) and median PFS 8,78 months (95% CI 7,53-10,07). OS was longer in patients with G814 (HR 0,61; 95%CI 0,39-0,97; p= 0,0584) and TUG8,5 (HR 0,55; 95%CI 0,35- 0,86; p= 0,0201). PFS was not influenced by G8 (HR 0,86; 95%CI 0,55-1,34; p= 0,5125) nor by TUG (HR 0,71; 95%CI 0,47-1,08). G814 and TUG8,5 conferred better OS also in the subgroup of RASmut (respectively p= 0,0133 and p= 0,0088). Worse OS was observed in presence of > 1 metastatic site (HR = 1,71; 95%CI 1,11 to 2,64; p= 0,0161). At the multivariate analysis, G814 ( p= 0,0202) and single metastatic site ( p= 0,0200) were related to better OS; none of the analysed variables had effect on PFS. Conclusions: In our study G814 and TUG8,5 had prognostic value in OS, but not in PFS, in a real-life population of elderly pts affected by mCRC. G8 and single metastatic site involvement were related to better OS, irrespectively of other clinical, histological and molecular variables.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Prognostic value of baseline G8 geriatric assessment in a real-life population of elderly metastatic colorectal cancer patients: The Gold Study.
Date Crossref: 01/06/2022
Éditeur: American Society of Clinical Oncology (ASCO)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Istituto Oncologico Veneto pays non établi dans la notice
Établissement de santé
Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la notice
Établissement de santé
Ospedale San Bortolo pays non établi dans la notice
Établissement de santé
Ospedale di Mirano pays non établi dans la notice
Établissement de santé
Ospedale Policlinico San Martino pays non établi dans la notice
Établissement de santé
Veneto Institute of Oncology IOV–IRCCS Medical Oncology 1 pays non établi dans la notice
Structure de recherche
Dipartimento di Oncologia Clinica UOC Oncologia di Belluno pays non établi dans la notice
Établissement de santé
San Bortolo General Hospital Department of Oncology pays non établi dans la notice
Établissement de santé
Oncology and Hemato-Oncology UOC - AULSS 3 Serenissima - Mirano (Venice) pays non établi dans la notice
Institution
Clinical Epidemiology Unit pays non établi dans la notice
Établissement de santé
Veneto Institute of Oncology IOV-IRCCS Department of Oncology pays non établi dans la notice
Structure de recherche

Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico et Ospedale San Bortolo, avec 8 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Frailty in Older AdultsColorectal Cancer Treatments and StudiesRadiomics and Machine Learning in Medical Imaging

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