Timothy Francis Walseth

CD38 / cADPR ‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1

Soner Doğan, Timothy Francis Walseth, Bilge Güvenç Tuna, Eda Uçar et autres

Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and …

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Diazirine-AIOC-NAADP, a Clickable-Photoactive NAADP Analog for Sea Urchin NAADP Binding Proteins

Yuqing Zhang, Zhong Zhen Guan, Jennifer N. Gadient, Sushil Kumar et autres

Calcium ions (Ca 2+ ) play a vital role as intracellular messengers, regulating essential cellular processes. Nicotinic acid adenine dinucleotide phosphate (NAADP) serves as a potent second messenger, responsible for releasing Ca 2+ in both mammals and echinoderms. Despite identification of two …

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Progesterone receptor membrane component 1 facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum

Gihan S. Gunaratne, Sushil Kumar, Yaping Lin-Moshier, James T. Slama et autres

Membrane contact sites (MCSs) between endosomes and the endoplasmic reticulum (ER) are thought to act as specialized trigger zones for Ca 2+ signaling, where local Ca 2+ released via endolysosomal ion channels is amplified by ER Ca 2+ -sensitive Ca 2+ channels …

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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12

Gihan S. Gunaratne, Eugen Brailoiu, Sushil Kumar, Yu Yuan et autres

The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca 2+ ) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP …

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Understanding the involvement of sphingosine kinase-1 and two-pore channels in calcium signaling in T cells

Giselle A. Borges e Soares, Emma H. George, Ali H. Hamzah, Timothy Francis Walseth et autres

Abstract Calcium (Ca2+) signaling is an essential requirement for cell activation, proliferation, differentiation, homeostasis, etc. In the tumor microenvironment, however, an upregulation of the Ca2+ signaling pathway has been associated with cancer cell proliferation and malignancy, which further contributes to immune response …

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Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N3-2′-O-propargyladenosine and 8-N3-2′-O-propargyl-cADPR

Divya Andy, Gihan S. Gunaratne, Jonathan S. Marchant, Timothy Francis Walseth et autres

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Identification of a dihydropyridine scaffold that blocks ryanodine receptors

Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan et autres

Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca 2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, arrhythmia, heart failure, and Alzheimer's disease. Therefore, there is …

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NAADP: From Discovery to Mechanism

Timothy Francis Walseth, Andreas H. Guse

Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca 2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP …

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HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation

Hannes G. Roggenkamp, Imrankhan Khansahib, Lola C. Hernandez, Yunpeng Zhang et autres

A protein that enables the activation of ryanodine receptors by NAADP in T cells is identified.

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Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling

Gihan S. Gunaratne, Eugen Brailoiu, Shijun He, Ellen M. Unterwald et autres

A protein that enables the activation of two-pore channels by NAADP is identified.

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Jupiter Microtubule Associated Homolog 2 is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Binding Protein Required for NAADP-Evoked Intracellular Calcium Release

Gihan S. Gunaratne, Eugen Brailoiu, Shijun He, Sandip Patel et autres

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Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs

Peiling Su, James D. Bretz, Gihan S. Gunaratne, Jonathan S. Marchant et autres

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