Eileen Socher

Molecular Dynamics Simulations of 4 GALC Variants Causing Krabbe Disease

Piet Ankermann, Silja I. Jenne, Jannes Talarek, Lukas Heger et autres

gene of patients with Krabbe disease. To investigate the effects of these mutations on protein structure, structural models of human GALC were built. These models served as the basis for a series of all-atom molecular dynamics (MD) simulations to analyze the structural …

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From essential basic understanding to clinical application – biological, physical and pathophysiological principles of (low-dose) radiotherapy in benign diseases

Lisa Deloch, David Rene Steike, Felix Pascher, Anne-Marie Thole et autres

Low dose radiotherapy (LDRT) is a radiation technique in the treatment of benign conditions to relieve symptoms and improve mobility and pain with minimal overall side effects. There are many reports describing the use of LDRT in the treatment of osteoarthritis (OA), …

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Molecular Characterization of the GALC Mutation Thr112Ala Causing Krabbe Disease

Lukas Heger, Piet Ankermann, Eileen Socher

Krabbe disease is a rare and severe lysosomal disorder affecting the white matter of the central and peripheral nervous system. It is characterized by neurodegeneration, with the most common form being infantile Krabbe disease, typically diagnosed within the first year of life. …

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Engineering Antiviral Peptides to Prevent the Cell Entry of Human Cytomegalovirus

Ruben Caspary, Eileen Socher

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Molecular Case Studies of GALC Mutations Causing Krabbe Disease

Eileen Socher, Piet Ankermann

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3D Cultivation of the Recently Established Human Lacrimal Gland Cell Line Serves as a Simplified Lacrimal Gland Model

Sophie Gleixner, Raphael Schwendner, Eileen Socher, Ingrid Zahn et autres

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New Translational Research Tools to Target Β-Glucocerebrosidase in Parkinson’s Disease

Philipp Arnold, Friederike Zunke, Jan Philipp Dobert, Jan-Hannes Schäfer et autres

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Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, P. N. Ravindran et autres

Targeting proteins to their final cellular destination requires transport mechanisms and nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway. One of the few known exceptions is the enzyme β-glucocerebrosidase (GCase) that requires the lysosomal integral membrane protein type-2 …

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Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo

Ingrid Zahn, Eileen Socher, Antonio Bergua, Thilo Schikorra et autres

PURPOSE: The meibomian glands produce a lipid-rich secretion that forms the superficial layer of the tear film, preventing excessive evaporation. Dysfunction of these glands (MGD) is the primary cause of dry eye disease (DED), a growing public health concern. Currently, there are …

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Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Jan Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran et autres

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Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target

Manfred Marschall, Martin Schütz, Markus Wild, Eileen Socher et autres

Herpesviral protein kinases, such as the therapy-relevant pUL97 of human cytomegalovirus (HCMV), are important for viral replication efficiency as well as pathogenesis, and represent key antiviral drug targets. HCMV pUL97 is a viral cyclin-dependent kinase (CDK) ortholog, as it shares functional and …

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Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model

Christiane Stahl‐Hennig, Antonia Sophia Peter, Arne Cordsmeier, Nicole Stolte‐Leeb et autres

, we compared the efficacy of two neutralizing monoclonal antibodies (TRES6 and 4C12) targeting different epitopes of the receptor binding domain (RBD) of SARS-CoV-2 in a prophylactic setting in rhesus monkeys. All four animals treated with TRES6 had reduced viral loads in …

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