The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice
Rattachement africain : es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Dietary restriction is a frequent strategy for weight loss, but adherence is difficult and returning to poor dietary habits can result in more weight gain than that previously lost. How weight loss due to unrestricted intake of a healthy diet affects the response to resumption of poor dietary habits is less studied. Moreover, whether this response differs between the sexes and if the insulin-like growth factor (IGF) system, sex dependent and involved in metabolic control, participates is unknown. Mice received rodent chow (6% Kcal from fat) or a high-fat diet (HFD, 62% Kcal from fat) for 4 months, chow for 3 months plus 1 month of HFD, or HFD for 2 months, chow for 1 month then HFD for 1 month. Males and females gained weight on HFD and lost weight when returned to chow at different rates (p < 0.001), but weight gain after resumption of HFD intake was not affected by previous weight loss in either sex. Glucose metabolism was more affected by HFD, as well as the re-exposure to HFD after weight loss, in males. This was associated with increases in hypothalamic mRNA levels of IGF2 (p < 0.01) and IGF binding protein (IGFBP) 2 (p < 0.05), factors involved in glucose metabolism, again only in males. Likewise, IGF2 increased IGFBP2 mRNA levels only in hypothalamic astrocytes from males (p < 0.05). In conclusion, the metabolic responses to dietary changes were less severe and more delayed in females and the IGF system might be involved in some of the sex specific observations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice
- Date Crossref
- 14/08/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto de Salud Carlos III Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) pays non établi dans la noticeOrganisation à but non lucratif
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Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition pays non établi dans la noticeStructure de recherche
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Hospital Infantil Universitario Niño Jesús Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
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Universidad Autónoma de Madrid pays non établi dans la noticeUniversité ou école supérieure
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Hospital Universitario Puerta de Hierro Majadahonda Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
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Madrid Institute for Advanced Studies pays non établi dans la noticeUniversité ou école supérieure
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IMDEA Food pays non établi dans la noticeStructure de recherche
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Department of Pediatrics pays non établi dans la noticeInstitution
Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) — Instituto de Salud Carlos III, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition et Department of Endocrinology — Hospital Infantil Universitario Niño Jesús, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.