2024
conference-abstract
OpenAlex
Senthil Ramalingam, Danying Cai, Lindsay S. Shopland, James Keck
Abstract Immuno-oncology cell therapies engage the immune system to treat cancer. In recent years, adoptive T-cell therapy with CD19-specific chimeric antigen receptors (CARs) has shown promise for treatment of various malignancies, including acute lymphoblastic leukemia. However, CAR-T-cell therapies have been hampered by …
us
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Accès ouvert
2023
article
OpenAlex
Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen et autres
Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating oligodendrocytes. We show that LMNA/C levels increase with differentiation of …
us
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Accès ouvert
2023
article
OpenAlex
Deep S. Shah, Brian W. Soper, Lindsay S. Shopland
Cancer is the leading cause of death worldwide. Cancer immunotherapy involves reinvigorating the patient's own immune system to fight against cancer. While novel approaches like Chimeric Antigen Receptor (CAR) T cells, bispecific T cell engagers, and immune checkpoint inhibitors have shown promising …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Deep S. Shah, Catalina Simion, Sang hu, Rhonda Chronis et autres
Abstract Cytokine Release Syndrome (CRS) is a systemic inflammatory response that is caused by the large, rapid release of cytokines in the blood by immune cells affected by infection or immunotherapy and remains a prominent challenge for T cell-based therapeutics. Bispecific T …
us
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2018
conference-abstract
OpenAlex
David A. Eavarone, Patricia E. Rao, Jillian M. Prendergast, Adam D. Curtis et autres
Abstract Introduction: Myeloid derived suppressor cells (MDSCs) are functionally defined by their capacity to suppress T cell immunity; therefore inhibiting these cells is of great interest for immuno-oncology applications. STn, the sialylated version of the carbohydrate Tn antigen, is broadly expressed in …
us
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2018
article
OpenAlex
Adam D. Curtis, Jens Rueter, Shelia Rajan, Rong Zhang et autres
Mantle cell lymphoma (MCL) presents a therapeutic challenge. The B cell targeting agent, ibrutinib, is currently one of the most effective second-line therapies for MCL, but frequently leads to development of drug resistance, and short overall survival time upon relapse. Olaparib targets …
us
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2017
conference-abstract
OpenAlex
Jillian M. Prendergast, David A. Eavarone, Patricia E. Rao, Adam D. Curtis et autres
Abstract Tumor-associated carbohydrate antigens (TACAs) historically have been challenging targets for antibody therapeutics. Sialyl-Tn (STn) is a cancer specific antigen that is expressed on the cell surface of carcinomas including ovarian, colon, prostate, and pancreatic tumors but is rarely present in normal …
us
(code pays fourni par la source)
2017
conference-abstract
OpenAlex
Adam D. Curtis, Todd A. Hoffert, Sheila Rajan, Jens Rueter et autres
Abstract Mantle cell lymphoma (MCL) presents a therapeutic challenge, with frequent relapses after therapy due to high levels of DNA damage and disease evolution. One currently approved MCL therapeutic, ibrutinib, is a tissue-specific agent with relatively few adverse effects. However, ibrutinib is …
us
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Accès ouvert
2016
conference-abstract
OpenAlex
Archana Gopalan, Stephanie Wood, Keiko Yamamoto, James Keck et autres
Many cytotoxic and targeted therapies show promising activity in cultured cells but most fail to show equivalent efficacy in patients, indicating that the predictive power of cell culture models is limited. While patient derived xenograft (PDX) models are more faithful models of …
us
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2016
conference-abstract
OpenAlex
Lindsay S. Shopland, Ivette F. Emery, Todd A. Hoffert, Rise Aalberg et autres
Abstract According to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer research. This shortage especially affects the generation of murine xenograft models of human cancers. Maine, with the third …
us
(code pays fourni par la source)
2016
conference-abstract
OpenAlex
Lindsay S. Shopland, Ivette F. Emery, Todd A. Hoffert, Rise Aalberg et autres
According to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer research. This shortage especially affects the generation of murine xenograft models of human cancers. Maine, with the third largest …
us
(code pays fourni par la source)
Accès ouvert
2015
article
OpenAlex
Ian C. Welsh, Hojoong Kwak, Frances L. Chen, Melissa Werner et autres
Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the dorsal mesentery (DM), whose asymmetric cell behavior directs gut looping. Despite the importance of organ laterality, chromatin-level regulation of Pitx2 remains undefined. Here, we show that …
us
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