Mathilde Pruvost

The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and Cell Death in Oligodendrocyte Progenitors

Mathilde Pruvost, Hyejin Park, Chloé Habermacher, Meng Li et autres

Oligodendrocyte progenitor cells (OPCs) represent a population of electrically active and dividing cells, which are capable of responding to neuronal activity by proliferating and differentiating. Here, we report that the repressive euchromatic H3K9me2 histone mark, deposited by the histone methyltransferases EHMT1 and …

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Correction: Pruvost, M.; Moyon, S. Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination. Life 2021, 11, 62

Mathilde Pruvost, Sarah Moyon

The authors wish to make the following corrections to this paper [...].

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Roles and benefits of inflammation marker assays in the management of autoinflammatory diseases: Case study of a patient with familial Mediterranean Fever

Mathilde Pruvost, Farah Bejar, Guillaume Lefèvre, Laure Calas

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The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen et autres

Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating oligodendrocytes. We show that LMNA/C levels increase with differentiation of …

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Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Mathilde Pruvost, Sarah Moyon

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of …

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Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging

Kelly Veerasammy, Yuki X. Chen, Sami Sauma, Mathilde Pruvost et autres

Metabolomics, the study to identify and quantify small molecules and metabolites present in an experimental sample, has emerged as an important tool to investigate the biological activities during development and diseases. Metabolomics approaches are widely employed in the study of cancer, nutrition/diet, …

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Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging

Kelly Veerasammy, Yuki X. Chen, Sami Sauma, Mathilde Pruvost et autres

Metabolomics, the study to identify and quantify small molecules and metabolites present in an experimental sample, has emerged as an important tool to investigate the biological activities during development and diseases. Metabolomics approaches are widely employed in the study of cancer, nutrition/diet, …

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Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Insup Choi, Yuanxi Zhang, Steven P. Seegobin, Mathilde Pruvost et autres

Microglia maintain brain homeostasis by removing neuron-derived components such as myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is growing; however, the precise mechanisms remain poorly understood. Herein, we report a neuroprotective role for microglia in the clearance of …

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Microglia Clear Neuron-released α-Synuclein via Selective Autophagy and Prevent Neurodegeneration

Insup Choi, Yuanxi Zhang, Steven P. Seegobin, Mathilde Pruvost et autres

Abstract Microglia maintain brain homeostasis by removing neuron-derived components such as myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is growing, however, the precise mechanisms remain poorly understood. Herein we report a neuroprotective role for microglia in the clearance …

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ADAMTS‐4 in oligodendrocytes contributes to myelination with an impact on motor function

Mathilde Pruvost, Matthieu Lépine, Camille Leonetti, Olivier Etard et autres

Abstract Myelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components. Accordingly, chondroitin sulfate proteoglycans (CSPGs) act as negative regulators of myelination processes. A disintegrin and metalloproteinase with thrombospondin motifs type 4 (ADAMTS‐4) …

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Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery

Miriana Jlenia Quattromani, Mathilde Pruvost, Carla Guerreiro, Fredrik Backlund et autres

Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke …

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Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet et autres

BACKGROUND: The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on factors which govern their proliferation, migration and differentiation. Tissue plasminogen activator (tPA) is …

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