Accès ouvert
2025
article
OpenAlex
Michael Superdock, Lisa M. Rimsza, Danielle S. Wallace, Myla Strawderman et autres
Primary mediastinal large B-cell lymphoma (PMBCL) is a rare subtype of non-Hodgkin lymphoma (NHL) that accounts for 2–4% of NHL cases [1,2]. It most commonly presents as a locally invasive anterior...
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2025
preprint
OpenAlex
Jinjun Cheng, Sarah E. Gibson, Ryan S. Robetorye
Abstract Mediastinal B-cell lymphomas are relatively frequent in young patients and include nodular sclerosis classic Hodgkin lymphoma (NSCHL), primary mediastinal large B-cell lymphoma (PMBL), and rarely, mediastinal gray zone lymphoma (MGZL). Occasional NSCHLs contain abundant Hodgkin/Reed Sternberg (HRS) cells that exhibit a …
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Accès ouvert
2023
article
OpenAlex
Colleen A. Ramsower, Allison Claire Rosenthal, Ryan S. Robetorye, Raphael Mwangi et autres
Mantle cell lymphoma (MCL) is clinically and biologically heterogeneous. While various prognostic features have been proposed, none currently impact therapy selection, particularly in older patients, for whom treatment is primarily dictated by age and comorbidities. Herein, we undertook a comprehensive comparison of …
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2023
article
OpenAlex
Charles Gaulin, Fiona E. Craig, Shannon P. Fortin Ensign, Ryan S. Robetorye et autres
To the Editor,Dendritic and histiocytic neoplasms are a diverse group of rare hematopoietic disorders characterized by the accumulation of cells from the monocytic, histiocytic, or dendritic lineag...
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Accès ouvert
2023
article
OpenAlex
Ryan S. Robetorye, Colleen A. Ramsower, Catherine Mckinney, Lisa M. Rimsza
Topic: 20. Lymphoma Biology & Translational Research Background: Although cell-of-origin (COO) determination in diffuse large B-cell lymphoma (DLBCL) and differentiation of primary mediastinal large B-cell lymphoma (PMBL) from DLBCL can be important for guiding subsequent therapy, the interpretation of morphologic and immunophenotypic …
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Accès ouvert
2022
article
OpenAlex
Tristan Loveday, Gerben Duns, Lisa M. Rimsza, Karen L. Rech et autres
We investigated the clinicopathologic features of 5 follicular lymphomas (FLs) that transformed (tFL) morphologically to diffuse large B-cell lymphomas (DLBCLs) and had a primary mediastinal large B-cell lymphoma (PMBL)-like gene expression profile (tFL-PMBLsig-pos). None of the tFL-PMBLsig-pos cases arose in the mediastinum, …
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Accès ouvert
2022
article
OpenAlex
Ryan S. Robetorye, Colleen A. Ramsower, C. L. McKinney, Lisa M. Rimsza
Background: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct lymphoid neoplasm arising in the mediastinum that is morphologically similar to diffuse large B-cell lymphoma (DLBCL), but has distinct clinical, immunophenotypic, genotypic, and molecular features. Although differentiation of PMBL from DLBCL can …
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2022
article
OpenAlex
Henry D. Zheng, Yassmeen Abdel‐Aty, Cullen A. Taylor, Jaime Engholdt et autres
OBJECTIVE: To characterize a clinical triad of symptoms associated with myeloid sarcomas of the temporal bone via a review of all previously reported cases. METHODS: Case report and Ovid MEDLINE database literature review. RESULTS: A literature search revealed that a clinical triad …
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2021
conference-abstract
OpenAlex
Allison Claire Rosenthal, Colleen A. Ramsower, Raphael Mwangi, Matthew J. Maurer et autres
Abstract BACKGROUND: Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with variable clinical outcomes. Commonly used risk stratification tools (Ki67 IHC, MIPI) in newly diagnosed MCL are not frequently used when selecting therapy, resulting in treatment choice being dictated by age …
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2021
conference-abstract
OpenAlex
Tristan Loveday, Gerben Duns, Lisa M. Rimsza, Karen L. Rech et autres
Abstract Objectives: We identified a case of follicular lymphoma (FL) that transformed into a morphologic diffuse large B-cell lymphoma (DLBCL), which by gene expression profiling showed a primary mediastinal (PMBL)-like gene expression profile (GEP) (Lymph3Cx; Blood 2018;132:2401-5). A search identified 4 additional …
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Accès ouvert
2020
article
OpenAlex
Colleen A. Ramsower, Alanna Maguire, Ryan S. Robetorye, Andrew L. Feldman et autres
Mantle cell lymphoma (MCL) is a clinically heterogeneous B cell malignancy for which a variety of prognostic factors have been proposed. Previously, a digital gene expression profiling "proliferation signature" capable of risk stratifying MCL was identified and subsequently developed into a multi-analyte …
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Accès ouvert
2020
article
OpenAlex
Kevin Charles Miller, Ryan S. Robetorye, James M. Foran
Donor cell leukemia is a very rare cause of relapse after allogeneic hematopoietic cell transplantation (alloHCT). Herein, we describe an unprecedented case of donor cell-derived chronic myelomonocytic leukemia (CMML) presenting seven years after a 51-year-old man received a matched-related alloHCT from his …
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