Bo Yi

Patterns of mechanical failure in the Coloplast Titan Touch inflatable penile prosthesis: a 12-year single-surgeon experience

Danni Feng, Ahmed Elshafei, Bo Yi, Vincent Eng et autres

BACKGROUND: Mechanical malfunction remains one of the most common causes of inflatable penile prosthesis failure, yet long-term data on the specific causes, failure locations, and timing remain limited. AIM: We aim to elucidate the mechanism, location, and timing of mechanical breakdown of …

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HNRNPC reprograms cancer metabolism to drive acquired chemoresistance in colorectal cancer by repressing of Nrf2/SLC7A11-dependent ferroptosis

Xiaojian Zhu, Shanshan Lin, Ling‐Ling Ruan, Jianyong Xiong et autres

Chemotherapeutic efficacy in colorectal cancer (CRC) is primarily driven‌ by adaptive mechanisms that circumvent therapy-induced ferroptosis. Despite the established role of ROS-mediated lipid peroxidation in initiating ferroptosis, the molecular regulators enabling cancer cells to escape this iron-dependent demise remain elusive. Here, we …

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DEHP induces hepatic fibrosis through STAT3-SLC7A11-ROS axis

Zhiliang Xu, Xiaoxiang You, Tinghao Yuan, Jun He et autres

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Tongxie Yaofang attenuates ulcerative colitis by modulating gut microbiota and IL-10RA/NF-κB-mediated macrophage polarization

Shang Zhao, Yue Liu, Feixiang Zhai, Y Chen et autres

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Targeting MED8 enhances sorafenib sensitivity in hepatocellular carcinoma by disrupting epithelial–mesenchymal transition mechanisms

Min Li, Xiaoxiang You, Tinghao Yuan, Jun He et autres

HCC is a highly lethal cancer characterised by significant sorafenib resistance, leading to poor patient outcomes. Recent studies have suggested that MED8 plays a role in enhancing tumour resistance to drugs, but its role in drug resistance in HCC has not yet …

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Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis

Weihong Wang, You Yu, Rui Wang, Yaxue Wang et autres

BACKGROUND: Current microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent …

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Endoscopic Evaluation of Ureteral Stone Impaction Highlights Significant Variability in Definitions Between Endourologists

Jared S. Winoker, Bo Yi, Robert T. Chang, Raymond Khargi et autres

Introduction: Previous studies attempting to predict impaction on CT have relied on various criteria without a gold standard for comparison. Intraoperative single-surgeon estimations of impaction have been unvalidated and subjective. This study aimed to investigate surgeon perspectives and variability in estimating ureteral …

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WITHDRAWN: 797P Irinotecan liposome combined with 5-FU/LV and bevacizumab as second-line therapy for metastatic colorectal cancer (IRIS): A prospective, multicenter, single-arm phase II study

Guiqi Wang, Xin Hu, Beibei Jiang, Hailing Lu et autres

Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function

Shujuan Zhang, B. Li, Xiao-Qun Han, Linlin Ruan et autres

Sanren Decoction (SRD), a traditional Chinese medicine formula historically used to relieve damp-heat and gastrointestinal disorders, demonstrates targeted efficacy in ulcerative colitis (UC)-a disease marked by chronic inflammation and mucosal damage-by acting on multiple pathological pathways. This study employed an integrative methodology …

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Near-rectangle electric field for a novel β-Ga2O3 nanomembrane MISFET with double linearly-doped drift layer: Analytical model and simulation

Bo Yi, Yuan Qiao, Fan Xu, Junji Cheng et autres

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A Novel SiC Trench MOSFET with Integrated Junction Barrier Schottky for Improved Performances

Bo Yi, Xinyi Wu, Tao Zhu, Junji Cheng et autres

In this paper, a novel SiC MOSFET with an integrated Junction Barrier Schottky diode (JBS) on the surface (named JBS-MOS) is proposed, which enhances the reverse conduction capability and reduces the switching losses, offering superior performances in power converter applications. Simulation results …

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Comprehensive Mechanistic Investigation of Sanren Decoction in Ulcerative Colitis: Enhancement of the Intestinal Barrier, Modulation of Macrophage Polarization, and Regulation of Gut Microbiota

Shujuan Zhang, B. Li, Xiao-Qun Han, Linlin Ruan et autres

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