Christopher J. Chang

Metalloadaptor and metallochaperone proteins reveal new chemical principles of biological metal homeostasis

Kelly Deng, Christopher J. Chang

Transition metals are essential nutrients that serve as metabolic cofactors and signaling agents in every cell type across all kingdoms of life. Owing to their relatively low abundance and high chemical reactivity, living organisms have evolved dedicated biochemical pathways to ensure active …

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Supplementary Figure 3 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

Characterization of prostate cancer patient-derived organoids by H&E and immunohistochemistry with anti-ATP7B and androgen receptor antibodies.

Supplementary Figure 1 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

ATP7B protein expression in prostate epithelial cells and prostate cancer cell lines

Supplementary Figure 5 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

H & E staining of 22Rv1-DR xenograft tumor tissues from mice treated with Vehicle control, docetaxel alone, DSF/CuCl2, and docetaxel plus DSF/CuCl2.

Supplementary Figure 6 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

Western blotting analysis of COMMED1, Skp2, p21, and α-Clusterin protein expression in vehicle control and DSF/CuCl2 treated 22Rv1-DR xenograft tumors.

Supplementary Figure 4 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

Knock-down of COMMD1 expression by siRNAs attenuates the effects of DSF/Cu++ reducing Skp2 protein levels in DU145-DR cells

Supplementary Figure 2 from ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Liankun Song, Vyvyan Nguyen, Jun Xie, Shang Jia et autres

The effect of docetaxel on the growth of DU145 parental cells after control siRNA or ATP7B siRNA transfections.

Chiral methionine oxidation reagents reveal stereospecific proteome modifications

Angel Gonzalez-Valero, Annika C. S. Page, Jayde M. Bertoch, Fadi Alsarhan et autres

Abstract Life is predicated on chirality, a molecular asymmetry akin to the left and right versions of human hands. Here we show that privileged protein residues are predisposed for chiral regulation. We developed enantiomeric oxaziridine reagents that systematically identify pro-( S ) …

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Copper Import via CTR1 Supports the β3-Adrenergic Thermogenic Program

Tae-Il Jeon, Young-Seung Lee, Tamara Korolnek, Juyoung Kim et autres

ABSTRACT Adaptive thermogenesis requires coordinated activation of mitochondrial oxidation and metabolic remodeling, yet the signals driving this coordination are incompletely understood. Here, we show that cold exposure and β3-adrenergic receptor (β3-AR) stimulation upregulate the high-affinity copper (Cu) importer CTR1 and promote Cu …

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Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans

Joy R Armendariz, Sean Teng, Camdyn Rakow, Raquel Herrera et autres

, excess zinc is stored in lysosomes in intestinal cells; this process involves increasing the expression of the zinc transporter CDF-2 and remodeling of lysosomes characterized by an increase in the volume of the expansion compartment. To determine if this is a …

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An Activity-Based Sensing Approach to Monitor Nanomaterial-Promoted Changes in Labile Metal Pools in Living Systems

Javier Bonet-Aleta, Aidan T. Pezacki, Miku Oi, Jose L. Hueso et autres

High Resolution Image Download MS PowerPoint Slide Metal-based nanoparticles are a promising class of materials for diagnosis and treatment of cancer and other diseases. However, mechanisms of action of these nanomedicines remain insufficiently understood due in large part to our limited understanding …

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pH signalling and regulation in pyridinium redox flow batteries

Mark E. Carrington, Xavier Lem, Kirya F. Miller, Jaeyeon Yang et autres

Pyridinium compounds are promising electrolyte candidates for aqueous flow batteries yet undergo complex parasitic processes involving free radical species that remain difficult to monitor, track and regulate. Inspired by biological redox signaling, we developed operando pH monitoring to accurately track native pyridinium …

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