Emily DiMango

PrecISE—a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort

Loren C. Denlinger, Loren C. Denlinger, Elliot Israel, Wendy C. Moore et autres

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Psychometric validity of the 22-item sinonasal outcome test in cystic fibrosis

Christine Liu, Jakob L. Fischer, J. Overdevest, Anna C. Zemke et autres

BACKGROUND: The 22-item sinonasal outcome test (SNOT-22) is widely used to evaluate quality of life (QOL) in cystic fibrosis chronic rhinosinusitis (CF-CRS) but lacks formal validation in people with CF (PwCF). This study explores the psychometric properties of the SNOT-22 following elexacaftor/tezacaftor/ivacaftor …

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Domain‐Specific Olfaction in Children and Adults in the Era of Modulator Therapy for Cystic Fibrosis

Jeremy P. Tervo, Emily DiMango, Hossein Sadeghi, Claire Keating et autres

BACKGROUND: Little is known about when people with cystic fibrosis (PwCF) begin to experience olfactory decline, or whether sustained use of novel highly effective modulator therapies (HEMT) is predictive of better olfaction. This study evaluated psychophysical olfactory performance and HEMT-associated olfactory outcomes …

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A Phase IIa, Single-Blind, Placebo-Controlled, Parallel-Group Study to Assess Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Brensocatib in Adults with Cystic Fibrosis

Michael W. Konstan, James Tolle, Emily DiMango, Patrick A. Flume et autres

Abstract Background and Objectives Brensocatib, an oral, competitive, and reversible inhibitor of dipeptidyl peptidase 1 (DPP1), reduces exacerbations and lung function decline in non-cystic fibrosis bronchiectasis (NCFBE). This study aimed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of brensocatib …

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Pleural Masses: A Case of Intrathoracic Splenosis Diagnosed Noninvasively

M. Desta, Emily DiMango

Abstract Introduction Intrathoracic splenosis (IS) is defined by heterotopic autotransplantation of splenic tissue following trauma or surgery to the spleen. It almost always presents as left sided pleural based masses several years following splenectomy. Diagnosis can often be challenging without use of …

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Feasibility of Home Air Quality Monitoring in Homes of Black Adults Living in New York City Receiving Care for Uncontrolled Asthma in a Federally Qualified Health Center

Maureen George, R. Khurana, Emily DiMango, Jean‐Marie Bruzzese et autres

Abstract Rationale: Because people spend as much as 90% of their time indoors, indoor air quality (IAQ) is particularly important to health. Climate change impacts IAQ via multiple mechanisms and gas appliances, the main residential source of methane, drives climate change. Poor …

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Self-reported Inhaled Corticosteroid Adherence, Inhaled Corticosteroid Beliefs, and Endorsement of Nonpharmacologic Management of Asthma Among Black Adults Enrolled in a Randomized Clinical Trial in Federally Qualified Health Centers

R. Khurana, Jean‐Marie Bruzzese, J. Haomiao, Marija Zeremski et autres

Abstract Rationale: Inhaled corticosteroid (ICS) use is lower in Black adults relative to White adults, even when access to treatment is equal. Lower adherence has been shown to be associated with negative ICS beliefs and a preference for non-pharmacologic treatments. However, these …

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Indoor Allergen Interventions in Homes and Schools for Managing Asthma

Ramin Beheshti, Wanda Phipatanakul, Emily DiMango, Torie Grant

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Exploration of Olfaction and ChiPSO in Pediatric Cystic Fibrosis

Tiana M. Saak, Jeremy P. Tervo, Alicia Wang, Emily DiMango et autres

Background/Objectives: Olfactory dysfunction (OD) is a common symptom among people with cystic fibrosis (PwCF) and contributes to environmental safety concerns, nutritional challenges, and an overall diminished quality of life. OD is perceived to progress along the lifespan in PwCF, often due to …

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Household Environmental Triggers And Asthma Quality Of Life Among Black Adults With Uncontrolled Asthma

Rhea Khurana, Jean‐Marie Bruzzese, Marija Zeremski, Andrea Cassells et autres

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C‐Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations

Jonathan B. Zuckerman, Alexandra C. Hinton, Thomas Lahiri, Charlotte C. Tenebäck et autres

OBJECTIVE: Although studies have examined changes in C-reactive protein (CRP) during pulmonary exacerbations (PEX) in people with cystic fibrosis (PwCF), few have evaluated CRP profiles across age groups. Here, we characterize age-related CRP responses to PEX treatment. METHODS: We measured CRP concentrations …

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Community partners identified implementation considerations prior to a randomized clinical trial for uncontrolled asthma in Federally Qualified Health Centers

Maureen George, Samrawit Solomon, Rhea Khurana, Safa Elkefi et autres

Background and Purpose: Federally Qualified Health Centers (FQHC) are critically important in addressing the unmet healthcare needs of individuals impacted by poverty. We used implementation science frameworks to advance understanding of perceived and actual facilitators and barriers to a novel asthma intervention …

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