Accès ouvert
2026
article
OpenAlex
Heather Callaway, Dawid S. Zyla, Kathryn M. Hastie, Stephanie S. Harkins et autres
Rabies continues to kill over 60,000 people per year despite life-saving vaccines and post-exposure treatments and costs billions of dollars in prevention and treatment. Preventing rabies deaths and reducing the global economic burden of the virus will require both developing a monoclonal …
us, ch, fr
(code pays fourni par la source)
2026
preprint
OpenAlex
Heather Callaway, Dawid S Zyla, Kathryn M. Hastie, Stephanie S. Harkins et autres
Rabies continues to kill over 60,000 people per year despite life-saving vaccines and post-exposure treatments, and costs billions of dollars in prevention and treatment. Preventing rabies deaths and reducing the global economic burden of the virus will require both developing a monoclonal …
us, ch, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Michael J. Norris, Lauren A. Henderson, Mohammed Nure Alam Siddiquey, Jieyun Yin et autres
us, ca
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Michael J. Norris, Lauren A. Henderson, Mohammed Nure Alam Siddiquey, Jieyun Yin et autres
SUMMARY Human cytomegalovirus (HCMV) causes severe birth defects, lifelong health complications, and $4 billion in annual costs in the United States alone. A major challenge in vaccine design is the incomplete understanding of the diverse protein complexes the virus uses to infect …
us, ca
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Haoyang Li, Tierra K. Buck, Michelle A. Zandonatti, Jieyun Yin et autres
Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antivirals or vaccines against LASV infection are still lacking. Furthermore, neutralizing …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Heng-Yi Chen, Ana Almonte-Loya, Fang-Yun Lay, Michael Hsu et autres
Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. From a …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Michael J. Norris, Monica L. Husby, William Bill Kiosses, Jieyun Yin et autres
Measles virus, Nipah virus, and multiple other paramyxoviruses cause disease outbreaks in humans and animals worldwide. The paramyxovirus matrix (M) protein mediates virion assembly and budding from host cell membranes. M is thus a key target for antivirals, but few high-resolution structures …
us, de
(code pays fourni par la source)
Accès ouvert
2022
peer-review
OpenAlex
Heng-Yi Chen, Ana Almonte-Loya, Fang-Yun Lay, Michael Hsu et autres
us
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Chan‐Wang Jerry Lio, Heng-Yi Chen, Ana Almonte-Loya, Fang-Yun Lay et autres
Abstract Ascorbate (vitamin C) is an essential micronutrient in humans. The chronic severe deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. Here, …
us, fr
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Michael J. Norris, Monica L. Husby, William Bill Kiosses, Jieyun Yin et autres
Abstract Measles virus, Nipah virus, and multiple other paramyxoviruses cause disease outbreaks in humans and animals worldwide. The paramyxovirus matrix (M) protein mediates virion assembly and budding from host cell membranes. M is thus a key target for antivirals, but few high-resolution …
us, de, sk
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Kathryn M. Hastie, Haoyang Li, Daniel Bedinger, Sharon L. Schendel et autres
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and …
us, nl, gb, au, tw, cn, kr, jp
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Heng-Yi Chen, Ana Alamonte-Loya, Fang-Yun Lay, Eric C. Johnson et autres
Abstract Ascorbate (vitamin C) is an essential micronutrient in humans. The chronic severe deficiency of ascorbate, termed scurvy , has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. …
us
(code pays fourni par la source)