Nicolás Manito

Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation

Lorena Herrador, José González‐Costello, Jordi Niubo-Bosch, Laura Calatayud-Samper et autres

Primary graft dysfunction (PGD) remains a major cause of early morbidity and mortality after a heart transplant (HTx). Understanding the donor-related mechanisms involved may help improve organ selection and post-HTx outcomes. This study aimed to explore the association between the donor serum …

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Effectiveness and safety of rivaroxaban in patients with atrial fibrillation and heart failure in clinical practice: an indirect comparison of national and international registries

José María Cepeda, Nicolás Manito, Alejandro Recio‐Mayoral, Iñaki Lekuona et autres

Background: The objective of the study was to analyze and compare the effectiveness and safety of rivaroxaban in patients with atrial fibrillation (AF) and heart failure (HF). Methods: The clinical profile and outcomes of the FARAONIC study were indirectly compared with those …

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Riesgo de eventos cardiovasculares graves tras agudizaciones de la EPOC: resultados del estudio EXACOS-CV en España

Salud Santos, Nicolás Manito, Joaquín Sánchez-Covisa, Ignacio Hernández et autres

Introducción y objetivos: Este estudio de la práctica real, el primero de su tipo en población española, tuvo como objetivo explorar el riesgo de eventos cardiovasculares graves y de muerte por todas las causas tras la agudización de la enfermedad pulmonar obstructiva …

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Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain

Salud Santos, Nicolás Manito, Joaquín Sánchez-Covisa, Ignacio Hernández‐González et autres

This real-world study—the first of its kind in a Spanish population—aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD). We included individuals with a COPD diagnosis …

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Endomyocardial biopsy: safety and prognostic utility in paediatric and adult myocarditis in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Long-Term Registry

Alida L.P. Caforio, Juan Pablo Kaski, Juan R. Gimeno, Perry Elliott et autres

BACKGROUND AND AIMS: Contemporary multicentre data on clinical and diagnostic spectrum and outcome in myocarditis are limited. Study aims were to describe baseline features, 1-year follow-up, and baseline predictors of outcome in clinically suspected or biopsy-proven myocarditis (2013 European Society of Cardiology …

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Implications of Molecular Markers in Brain-Dead Donors in Primary Graft Dysfunction and Rejection After Heart Transplantation: The Potential Role of Preconditioning

L. Herrador-Galindo, José González‐Costello, Jordi Niubo-Bosch, M. Farrero Torres et autres

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Cardiomyopathies in children and adolescents: aetiology, management, and outcomes in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Registry

Gabrielle Norrish, Juan R. Gimeno, Philippe Charron, Perry Elliott et autres

BACKGROUND AND AIMS: Childhood-onset cardiomyopathies are rare and poorly characterized. This study examined the baseline characteristics and 1-year follow-up of children with cardiomyopathy in the first European Cardiomyopathy Registry. METHODS: Prospective data were collected on individuals aged 1-<18 years enrolled in the …

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Factors associated with disease progression in patients with atrial fibrillation and heart failure anticoagulated with rivaroxaban

Nicolás Manito, J.M. Cepeda-Rodrigo, Núria Farré, M. Castillo Orive et autres

BACKGROUND: Patients with atrial fibrillation (AF) and heart failure (HF) have a high risk of thromboembolism and other outcomes and anticoagulation is recommended. HYPOTHESIS: This study was aimed to explore the risk factors associated with HF worsening in patients with AF and …

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Increased risk of decompensated heart failure, acute coronary syndrome, arrythmias and ischemic stroke following exacerbation of COPD: results from a multi-database cohort study

Nathaniel M. Hawkins, Claus Vogelmeier, Sami O. Simons, Edeltraut Garbe et autres

Abstract Introduction The risk of acute coronary syndrome (ACS), stroke or death is increased following an exacerbation of chronic obstructive pulmonary disease (COPD). However, little is known about the risk of decompensated heart failure (HF) or acute arrhythmias. Purpose To quantify the …

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Increased risk of severe cardiovascular events following exacerbations of COPD: a multi-database cohort study

Claus Vogelmeier, Sami O. Simons, Edeltraut Garbe, Don D. Sin et autres

Introduction: Risk of severe cardiovascular events (CVE) increases following severe exacerbations of COPD (ECOPD). However, the duration of increased risk and the effect of moderate ECOPD are unclear. Objective: To quantify risk of a severe CVE or death following a moderate or …

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Outcomes and factors associated with mortality in patients with atrial fibrillation and heart failure: FARAONIC study

Juan José Gómez‐Doblas, J.M. Cepeda-Rodrigo, Rosa Agra Bermejo, E. Labrador et autres

Abstract Background Heart failure (HF) and atrial fibrillation (AF) are common and coexistent conditions. Hypothesis To investigate the adverse events and mortality risk factors in patients with AF and HF treated with rivaroxaban in Spain. Methods Multicenter, prospective and observational study with …

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Including KDIGO cardiovascular risk stratification into SCORE scale could improve the accuracy to better stratify cardiovascular risk

Ana Cebrián, Carlos Escobar, Unai Aranda, Beatriz Palacios et autres

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