Christian Dall Johansen

The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease

Josephine Grandt, Christian Dall Johansen, Anne‐Sofie Houlberg Jensen, Mikkel Parsberg Werge et autres

The human liver is dynamic organ with minute to hourly adaptions in response to feeding. Patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis have altered transcriptomic features compared to controls but how and if food intake affects such is unknown in …

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Glucagon receptor activation contributes to the development of kidney injury

Anna Billeschou, Christian Dall Johansen, Katrine Douglas Galsgaard, Emilie Elmelund et autres

This study suggests that the glucagon receptor is a potential therapeutic target in the treatment of diabetic kidney disease. We show, in mice, that long-term treatment with a glucagon analog showed not only pathophysiological changes and changes in renal function but also …

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The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease

Josephine Grandt, Christian Dall Johansen, Anne‐Sofie Houlberg Jensen, Mikkel Parsberg Werge et autres

Abstract The human liver is dynamic organ with minute to hourly adaptions in response to feeding. Patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis have altered transcriptomic features compared to controls but how and if food intake affects such is unknown …

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Postprandial dysfunction in fatty liver disease

Josephine Grandt, Anne‐Sofie Houlberg Jensen, Mikkel Parsberg Werge, Elias Badal Rashu et autres

Abstract Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important. Here, we investigated postprandial changes in markers of metabolic dysfunction between healthy individuals, obese individuals with …

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A Web-Based Browsable Resource of Hepatic Gene Expression in Healthy and Liver Disease

Josephine Grandt, Christian Dall Johansen, Anne‐Sofie Houlberg Jensen, Mikkel Parsberg Werge et autres

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Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression

Anna Billeschou, Christian Dall Johansen, Jens Bager Christensen, Sasha A. S. Kjeldsen et autres

Glucagon is a major regulator of metabolism and drugs targeting the glucagon receptor (GCGR) are being developed. Insight into tissue and cell-specific expression of the GCGR is important to understand the biology of glucagon and to differentiate between direct and indirect actions …

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Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Katrine Douglas Galsgaard, Emilie Elmelund, Christian Dall Johansen, Hüsün Sheyma Kizilkaya et autres

OBJECTIVE: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice. METHODS: ) mice, and in C57Bl/6JRj mice treated …

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Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells

Emilie Elmelund, Katrine Douglas Galsgaard, Christian Dall Johansen, Samuel A.J. Trammell et autres

The pancreatic hormone, glucagon, is known to regulate hepatic glucose production, but recent studies suggest that its regulation of hepatic amino metabolism is equally important. Here, we show that chronic glucagon receptor activation with a long-acting glucagon analog increases amino acid catabolism …

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214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

EMILIE E. CHRISTENSEN, Katrine Douglas Galsgaard, Christian Dall Johansen, SAMUEL TRAMMELL et autres

Amino acids control alpha cell secretion and growth, while glucagon stimulates hepatic amino acid uptake and ureagenesis, forming the liver-alpha cell axis. Patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes have increased levels of glucagon and amino acids pointing …

Hepatic Glucagon Receptor Signaling Controls Amino Acid Metabolism and Regulates Alpha Cell Mass

Emilie Elmelund, Katrine Douglas Galsgaard, Christian Dall Johansen, Samuel A.J. Trammell et autres

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Evaluation of Commercially Available Glucagon Receptor Antibodies and Glucagon Receptor Expression

Anna Billeschou, Christian Dall Johansen, Sasha A. S. Kjeldsen, Katrine Douglas Galsgaard et autres

Abstract Glucagon is a key regulator of numerous metabolic functions including glucose, protein and lipid metabolism, and glucagon-based therapies are explored for diabetes, fatty liver disease and obesity. Insight into tissue and cell specific expression of the glucagon receptor (GCGR) is important …

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