Postprandial dysfunction in fatty liver disease
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Le résumé fourni par la source
Abstract Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important. Here, we investigated postprandial changes in markers of metabolic dysfunction between healthy individuals, obese individuals with non‐alcoholic fatty liver disease (NAFLD) and patients with cirrhosis. We included individuals with biopsy‐proven NAFLD ( n = 9, mean age 50 years, mean BMI 35 kg/m 2 , no/mild fibrosis), cirrhosis with hepatic steatosis ( n = 10, age 62 years, BMI 32 kg/m 2 , CHILD A/B) and healthy controls ( n = 10, age 23, BMI 25 kg/m 2 ), randomized 1:1 to fasting or standardized mixed meal test (postprandial). None of the patients randomized to mixed meal test had type 2 diabetes (T2D). Peripheral blood was collected for 120 min. After 60 min, a transjugular liver biopsy and liver vein blood was taken. Plasma levels of glucose, insulin, C‐peptide, glucagon, and fibroblast growth factor 21 (FGF21) were measured. Postprandial peak glucose and C‐peptide were significantly increased in NAFLD, and cirrhosis compared with healthy. Patients with NAFLD and cirrhosis had hyperglucagonemia as a potential sign of glucagon resistance. FGF21 was increased in NAFLD and cirrhosis independent of sampling from the liver vein versus peripheral blood. Glucagon levels were higher in the liver vein compared with peripheral blood. Patients with NAFLD and cirrhosis without T2D showed impaired glucose tolerance, hyperinsulinemia, and hyperglucagonemia after a meal compared to healthy individual. Postprandial characterization of patients with NAFLD may be important to capture their metabolic health.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Postprandial dysfunction in fatty liver disease
- Date Crossref
- 01/04/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Copenhagen Novo Nordisk Foundation Center for Protein Research pays non établi dans la noticeUniversité ou école supérieure
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Novo Nordisk Foundation pays non établi dans la noticeStructure de recherche
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Hvidovre Hospital pays non établi dans la noticeÉtablissement de santé
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Copenhagen University Hospital Gastro Unit pays non établi dans la noticeÉtablissement de santé
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Frederiksberg Hospital pays non établi dans la noticeÉtablissement de santé
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Aalborg University Center for RNA Medicine pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health and Medical Sciences Novo Nordisk Foundation Center for Protein Research pays non établi dans la noticeUniversité ou école supérieure
Novo Nordisk Foundation Center for Protein Research — University of Copenhagen, Novo Nordisk Foundation et Hvidovre Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.